Less known aspects of central hypothyroidism: Part 1- Acquired etiologies
Open accessAbstract
Central hypothyroidism (CH) is a rare cause of hypothyroidism. CH is frequently overlooked, as its clinical picture is subtle and includes non-specific symptoms; furthermore, if measurement of TSH alone is used to screen for thyroid function, TSH concentrations can be normal or even above the upper normal reference limit. Indeed, certain patients are at risk of developing CH, such as those with a pituitary adenoma or hypophysitis, those who have been treated for a childhood malignancy, have suffered a head trauma, sub-arachnoid hemorrhage or meningitis, and those who are on drugs capable to reduce TSH secretion.
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Central hypothyroidism was considered 1,000-fold rarer than primary hypothyroidism, but it may be just 20-fold rarer.
“Central hypothyroidism (CH) was considered 1,000-fold rarer than PH, but it may be just 20-fold rarer (3).”
From L-T4 therapy in the presence of pharmacological interferents (2020) · cites this paper as [3]
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References 120 · Cited by 19
Research works printed but not linked: 2
- [2]Persani L. Beck-Peccoz P. Central hypothyroidism Braverman L.E. Cooper D.S. Werners & Ingbar’s The thyroid. A clinical and fundamental text 10th ed. 2013 Wolters Kluwer, Lippincott Williams & Wilkins Philadelphia 560 568
- [8]Van Vliet G. Deladoey D. Hypothyroidism in infants, children and adolescents: acquired hypothyroidism Braverman L.E. Cooper D.S. Werners & Ingbar’s The thyroid. A clinical and fundamental text 10th ed. 2013 Wolters Kluwer, Lippincott Williams & Wilkins Philadelphia 797 802
- Authors
- Benvenga, S., Klose, M., Vita, R., & Feldt-Rasmussen, U.
- Affiliations
- University of Messina (IT)
- University of Copenhagen (DK)
- Corresponding author
- Vita, Roberto
- Venue
- Journal of Clinical & Translational Endocrinology
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 14
- Pages
- 25-33
- ISSN
- 2214-6237 (ISSN-L)
- PMC
- PMC6205405
- OpenAlex
- W2894038018
- Cited by
- 19
- References
- 120
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 1
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Clinical & Translational Endocrinology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- central hypothyroidism, acquired hypothyroidism, TSH measurement, pituitary adenoma, hypophysitis, childhood cancer survivors, head trauma, subarachnoid hemorrhage, meningitis, thyroid screening
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