Emerging respiratory agents: New viruses for old diseases?
Open accessAbstract
The recent advances in molecular technology have enabled the detection of several new viral agents in specimens collected from the human respiratory tract. Human metapneumovirus was first described in 2001, and is a significant respiratory pathogen, particularly of children. Following the identification of severe acute respiratory syndrome (SARS) associated coronavirus, two other newly detected coronaviruses, NL63 and HKU1, have been linked to respiratory disease in humans. However, identifying a new virus as the causative agent of a specific disease is difficult, and ideally would involve satisfying Koch's postulates. The recently described human bocavirus and polyomaviruses KI and WU have been detected in samples collected from humans with acute respiratory infection, but as yet, have not been conclusively proven to be agents of human disease. We review the new viral agents that have been detected in respiratory samples since 2001, and examine their contribution as agents of human disease.
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Airway epithelial cells are increasingly recognized as important players in processes driving local cDC differentiation and maturation via production of various cytokines, including IL-15, TSLP, and type I IFNs.
“Airway epithelial cells are increasingly recognized as important players in the processes driving local cDC differentiation and maturation via production of various cytokines, including IL-15, thymic stromal lymphopoietin (TSLP), and type I IFNs (227, 230, 272, 289).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [272]
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References 151 · Cited by 124
Research works printed but not linked: 1
- Holmes K. Coronaviruses Knipe D. Howley P. Fields Virology 2001 Lippincott Williams & Wilkins Philadelphia 1187 1203
- Authors
- Sloots, T. P., Whiley, D. M., Lambert, S. B., & Nissen, M. D.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Sloots, T.P.
- Venue
- Journal of Clinical Virology
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 42
- Issue
- 3
- Pages
- 233-243
- ISSN
- 1386-6532 (ISSN-L)
- PMC
- PMC7108325
- OpenAlex
- W2134501494
- Cited by
- 124
- References
- 151
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 8 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 8
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Literature Analysis and Criticism
- Keywords
- respiratory viruses, human metapneumovirus, SARS-associated coronavirus, coronavirus NL63, coronavirus HKU1, human bocavirus, acute respiratory infections, Koch's postulates, viral pathogenicity, children
- MeSH terms
- Humans, Respiratory Tract Infections, Virus Diseases, Viruses, Communicable Diseases, Emerging
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