CoChat
Sign Up
Cited by 27Viral Infections and VectorsVirology and Viral DiseasesViral Infections and Outbreaks Research

The DOI matches its Crossref record.

Hantavirus infections by Puumala or Dobrava-Belgrade virus in pregnant women

Hofmann, Jörg, Führer, Andreas, Bolz, Michael, Waldschläger-Terpe, Juliane, Meier, Markus, Lüdders, Dörte, Enders, Martin, Oltmann, Anke, Meisel, Helga, Krüger, Detlev H.·2012·Journal of Clinical Virology
DOI 10.1016/j.jcv.2012.07.011
Open this paper in CoChat — free account

Abstract

Background Hantavirus infection in humans usually occurs via inhalation of infectious aerosolized excreta of rodents. Horizontal human-to-human transmission was reported only for the highly virulent Andes virus. The likelihood of vertical transmission and the clinical outcome of hantavirus infections in pregnancy is still unpredictable. Objectives Very few data were published about the impact of hantaviruses in pregnancy. Here we present four cases of pregnant women infected by European hantaviruses. The risk of vertical virus transmission was investigated. Study design Four pregnant women with clinical signs of acute hantavirus disease were investigated for hantavirus IgM and IgG after onset of clinical symptoms. Furthermore, the newborns were tested for presence of viral RNA and antibodies in cord blood and, if any parameter was found positive, 8-12 months after delivery. Results Four women suffered from a hantavirus infection, two of them due to infection by Puumala virus and two by Dobrava-Belgrade virus. Three women delivered healthy babies by vaginal route and one woman by Caesarean section (week 28). In no case hantavirus RNA was detected in cord blood after delivery or in the 8-12 month old babies. Hantavirus IgG was detectable in the cord blood of 3 babies (but not in the preterm child); these antibodies disappeared after 8-12 months indicating a passive transfer of immunoglobulins. No child had any clinical sign of hantavirus infection. Conclusions In this study, th…

Overview

Integrity signals

Registry

Crossref · 10.1016/j.jcv.2012.07.011

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 22

  1. Kruger, 2011, Human pathogenic hantaviruses and prevention of infection, Hum Vaccin, 7, 685, 10.4161/hv.7.6.15197 · DOI
  2. Hofmann, 2008, Hantavirus outbreak, Germany, 2007, Emerg Infect Dis, 14, 850, 10.3201/eid1405.071533 · DOI
  3. Klempa, 2004, First molecular identification of human Dobrava virus infection in central Europe, J Clin Microbiol, 42, 1322, 10.1128/JCM.42.3.1322-1325.2004 · DOI
  4. Huttunen, 2011, Systematic literature review of symptoms, signs and severity of serologically confirmed nephropathia epidemica in paediatric and adult patients, Scand J Infect Dis, 43, 405, 10.3109/00365548.2011.559666 · DOI
  5. Schutt, 2001, Clinical characterization of Dobrava hantavirus infections in Germany, Clin Nephrol, 55, 371
  6. Schneider, 2009, The first French hemorrhagic fever with renal syndrome in pregnant woman, J Gynecol Obstet Biol Reprod (Paris), 38, 440, 10.1016/j.jgyn.2009.04.011 · DOI
  7. Silberberg, 1993, Haemorrhagic fever with renal syndrome and pregnancy: a case report, Trans R Soc Trop Med Hyg, 87, 65, 10.1016/0035-9203(93)90425-P · DOI
  8. Georges, 2008, Nephropathia epidemica as the result of a Puumala virus infection in a pregnant patient, Dtsch Med Wochenschr, 133, 1830, 10.1055/s-0028-1082803 · DOI
  9. Nowakowska, 2009, The first established focus of hantavirus infection in Poland, 2007, Ann Agric Environ Med, 16, 79
  10. Pettersson, 2008, Outbreak of Puumala virus infection, Sweden, Emerg Infect Dis, 14, 808, 10.3201/eid1405.071124 · DOI
  11. Partanen, 1990, Infection with the Puumala virus in pregnancy. Case report, Br J Obstet Gynaecol, 97, 274, 10.1111/j.1471-0528.1990.tb01795.x · DOI
  12. Partanen, 1993, Lack of evidence of Puumala virus infection in patients with spontaneous abortion, Eur J Clin Microbiol Infect Dis, 12, 142, 10.1007/BF01967594 · DOI
  13. Klempa, 2010, Serological evidence of human hantavirus infections in Guinea, West Africa, J Infect Dis, 201, 1031, 10.1086/651169 · DOI
  14. Klempa, 2006, Hantavirus in African wood mouse, Guinea, Emerg Infect Dis, 12, 838, 10.3201/eid1205.051487 · DOI
  15. Gilson, 1994, Hantavirus pulmonary syndrome complicating pregnancy, Am J Obstet Gynecol, 171, 550, 10.1016/0002-9378(94)90298-4 · DOI
  16. Howard, 1999, Hantavirus pulmonary syndrome in pregnancy, Clin Infect Dis, 29, 1538, 10.1086/313513 · DOI · Paper page
  17. Kim, 2006, Hemorrhagic fever with renal syndrome complicated with pregnancy: a case report, Korean J Intern Med, 21, 150, 10.3904/kjim.2006.21.2.150 · DOI
  18. Lee, 1989, Hemorrhagic fever with renal syndrome in Korea, Rev Infect Dis, 11, S864
  19. Ma, 2003, Hemorrhagic fever with renal syndrome presenting with intrauterine fetal death. A case report, J Reprod Med, 48, 661
  20. Liu, 1987, Intrauterine infection of epidemic hemorrhagic fever (EHF) via placenta, Chin Med J (Engl), 100, 756
  21. Heyman, 2011, A five-year perspective on the situation of haemorrhagic fever with renal syndrome and status of the hantavirus reservoirs in Europe, 2005–2010, Euro Surveill, 16, 10.2807/ese.16.36.19961-en · DOI
  22. Faber, 2010, Steep rise in notified hantavirus infections in Germany, April 2010, Euro Surveill, 15, 10.2807/ese.15.20.19574-en · DOI

Cited by

Sorted by citations

  • Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review

    Toledo, J., Haby, M. M., Reveiz, L., Sosa Leon, L., Angerami, R., & Aldighieri, S. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab461 · Cited by 78

    “The remaining 14 studies used noncomparative designs, 10 of which involved the investigation of 1 or more clusters of cases [8–11, 25, 26, 32, 33, 35, 37], 2 were serological surveys of contacts [13, 14], and 2 investigated pregnant women with hantavirus infection for the possibility of vertical transmission of infect…”
    Background

See all 27

Metadata

Authors
Hofmann, J., Führer, A., Bolz, M., Waldschläger-Terpe, J., Meier, M., Lüdders, D., Enders, M., Oltmann, A., Meisel, H., & Krüger, D. H.
Affiliations
  • Charité – Universitätsmedizin Berlin (DE)
  • Universitätsmedizin Rostock (DE)
  • University of Rostock (DE)
  • University Hospital Schleswig-Holstein (DE)
Corresponding author
Hofmann, Jörg
ORCID
Venue
Journal of Clinical Virology
Publisher
Elsevier BV
Published
2012-11
Volume
55
Issue
3
Pages
266-269
ISSN
1386-6532 (ISSN-L)
DOI
10.1016/j.jcv.2012.07.011
OpenAlex
W2131215523
Cited by
27
References
0
Citations by year
2026: 5 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 2 · 2015: 1 · 2013: 6
FWCI
1.55
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Clinical Virology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Robert Koch Institut
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
Keywords
hantavirus infection, Puumala virus, Dobrava-Belgrade virus, pregnancy, vertical transmission, umbilical cord blood, neonates, IgM and IgG antibodies, rodent-borne zoonoses, Andes virus
MeSH terms
Adult, Antibodies, Viral, Female, Fetal Blood, Orthohantavirus, Humans, Immunoglobulin G, Immunoglobulin M, Infant, Newborn, Male, Pregnancy, Pregnancy Complications, Infectious, RNA, Viral, Infectious Disease Transmission, Vertical, Hantavirus Infections, Puumala virus, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Hantavirus infections by Puumala or Dobrava-Belgrade virus in pregnant women. https://app.cochat.ai/papers/10.1016/j.jcv.2012.07.011
The paper
Hofmann, J., Führer, A., Bolz, M., Waldschläger-Terpe, J., Meier, M., Lüdders, D., Enders, M., Oltmann, A., Meisel, H., & Krüger, D. H. (2012). Hantavirus infections by Puumala or Dobrava-Belgrade virus in pregnant women. Journal of Clinical Virology. https://doi.org/10.1016/j.jcv.2012.07.011