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Long-term remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo: A systematic review

Li, Jialing, Xie, Xiaoqiu, Wang, Yu, Yin, Wei, Antoun, Joseph S., Farella, Mauro, Mei, Li·2014·Journal of Dentistry
DOI 10.1016/j.jdent.2014.03.015
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Abstract

Objective To assess the long-term (>3 months) remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo. Data sources PubMed, Web of Science, Embase, Cochrane-Central, Science Direct, CBM, and CNKI were searched up to April 2013. Only articles in English and Chinese were included. Grey literature was also searched. Randomized or quasi-randomized clinical trials in which CPP-ACP was delivered by any method were considered. All relevant studies underwent two independent reviews. Study selection Of the 738 studies screened, 83 studies were reviewed and eight selected for inclusion in the final sample. The follow-up period of the studies included varied from 3 to 24 months. The long-term remineralizing effect of CPP-ACP in vivo was demonstrated in comparison with placebo in randomized controlled trial. However, there is conflicting evidence regarding the clinical efficacy of CPP-ACP when used in conjunction with fluoride toothpastes. No specific side effect related to CPP-ACP usage was found. Conclusions CPP-ACP has a long-term remineralizing effect on early caries lesions in comparison with placebo, although this does not appear to be significantly different from that of fluorides. The advantage of using CPP-ACP as a supplement to fluoride-containing products is still unclear. High-quality, well-designed clinical studies in this area are still required before definitive recommendations can be made. Clinical significance…

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Metadata

Authors
Li, J., Xie, X., Wang, Y., Yin, W., Antoun, J. S., Farella, M., & Mei, L.
Venue
Journal of Dentistry
Publisher
Elsevier BV
Published
2014-07
Volume
42
Issue
7
Pages
769-777
ISSN
0300-5712
DOI
10.1016/j.jdent.2014.03.015
Cited by
108
References
3
Language
en
Licence
Funders
National Natural Science Foundation of China (81301476, 81070807)

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