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Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats
Abstract
Amalkadi Ghrita (AG), a polyherbal formulation, was evaluated for its hepatoprotective activity against carbon tetrachloride (CCl4)-induced hepatic damage in rats. The hepatoprotective activity of AG was evaluated by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), and acid phosphatase (ACP). The serum levels of total proteins and bilirubin were also estimated. The histological studies were also carried out to support the above parameters. Silymarin was used as standard drug. Administration of AG (100 and 300 mg/kg, p.o.) markedly prevented CCl4-induced elevation of levels of serum GPT, GOT, ACP, ALP, and bilirubin. The decreased level of total proteins due to hepatic damage induced by CCl4 was found to be increased in AG-treated group. The results are comparable to that of silymarin. A comparative histopathological study of liver exhibited almost normal architecture, as compared to CCl4-treated group. Hepatoprotective effect of AG is probably due to combined action of all ingredients.
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The study of hepatic markers such as AST, ALT, ALP, TB and TP have been found to be of great value in the assessment of clinical and experimental liver damage.
“The study of hepatic markers such as AST, ALT, ALP, TB and TP have been found to be of great value in the assessment of clinical and experimental liver damage. 40”
From Caralluma umbellata Haw. protects liver against paracetamol toxicity and inhibits CYP2E1 (2017) · cites this paper as [40]
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Research works printed but not linked: 15
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Caralluma umbellata Haw. protects liver against paracetamol toxicity and inhibits CYP2E1
Bellamakondi, P. K., Godavarthi, A., & Ibrahim, M. (2017) · BioImpacts · doi:10.15171/bi.2018.04 · Cited by 15
Metadata
- Authors
- Achliya, G. S., Wadodkar, S. G., & Dorle, A. K.
- Affiliations
- Rashtrasant Tukadoji Maharaj Nagpur University (IN)
- Corresponding author
- Achliya, Girish S
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 90
- Issue
- 2-3
- Pages
- 229-232
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2012758233
- Cited by
- 192
- References
- 0
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 4 · 2023: 9 · 2022: 8 · 2021: 6 · 2020: 4 · 2019: 9 · 2018: 7 · 2017: 13 · 2016: 15 · 2015: 8 · 2014: 9 · 2013: 13 · 2012: 18
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Silymarin and Mushroom Poisoning
- Keywords
- hepatoprotection, carbon tetrachloride, liver injury, polyherbal formulation, transaminases, alkaline phosphatase, acid phosphatase, bilirubin, silymarin, liver histopathology, Ayurveda
- MeSH terms
- Animals, Carbon Tetrachloride Poisoning, Cattle, Chemistry, Pharmaceutical, Dietary Fats, Drug Evaluation, Preclinical, Female, Glycyrrhiza, Liver, Male, Medicine, Ayurvedic, Phytotherapy, Phyllanthus emblica, Rats
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