Valproate is protective against 6-OHDA-induced dopaminergic neurodegeneration in rodent midbrain: A potential role of BDNF up-regulation
Open accessAbstract
BACKGROUND/PURPOSE: The main purpose of this study was to extend previously reported showing potent neuroprotective effect of valproic acid (VPA) in primary midbrain neuro-glial cultures to investigate whether VPA could protect dopamine (DA) neurons in vivo against 6-hydroxydopamine (6-OHDA)-induced neurodegeneration and to determine the underlying mechanism. METHODS: Male adult rats received a daily intraperitoneal injection of VPA or saline for two weeks before and after injection of 5, 10, or 15 μg of 6-OHDA into the brain. All rats were evaluated for motor function by rotarod performance. Brain samples were prepared for immunohistochemical staining and for determination of levels of dopamine, dopamine metabolites, and neurotrophic factors. RESULTS: 6-OHDA injection showed significant and dose-dependent damage of dopaminergic neurons and decrease of striatal dopamine content. Rats in the VPA-treated group were markedly protected from the loss of dopaminergic neurons and showed improvements in motor performance, compared to the control group at the moderate 6-OHDA dose (10 μg). VPA-treated rats also showed significantly increased brain-derived neurotrophic factor (BDNF) levels in the striatum and substantia nigra compared to the levels in control animals. CONCLUSION: Our studies demonstrate that VPA exerts neuroprotective effects in a rat model of 6-OHDA-induced Parkinson's disease (PD), likely in part by up-regulation BDNF.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 42 · Cited by 18
- Authors
- Lai, C.-L., Lu, C.-C., Lin, H.-C., Sung, Y.-F., Wu, Y.-P., Hong, J.-S., & Peng, G.-S.
- Affiliations
- Chang Gung University of Science and Technology (TW)
- National Defense Medical Center (TW)
- National Institutes of Health (US)
- Taipei Veterans General Hospital (TW)
- Corresponding author
- Lai, Ching-Long
- Peng, Giia-Sheun
- Venue
- Journal of the Formosan Medical Association
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 118
- Issue
- 1
- Pages
- 420-428
- ISSN
- 0929-6646 (ISSN-L)
- PMC
- PMC6456053
- OpenAlex
- W2883021831
- Semantic Scholar
- a56d52df231f03dfc79f75c3a2c8c3e433173f75
- Cited by
- 18
- References
- 42
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of the Formosan Medical Association (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministry of Science and Technology (NSC 98-2314-B-016-031-MY1 & 2, NSC 100-2314-B-016-001, NSC 102-2314-B-016-027)
- Ministry of National Defense (MAB101-57, 103-M082)
- Taipei Veterans General Hospital, Hsinchu Branch (2017–VHCT-RD-6, 2018–VHCT-RD-3)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- valproic acid, neuroprotection, 6-hydroxydopamine, dopaminergic neuron loss, Parkinson's disease, brain-derived neurotrophic factor, substantia nigra, striatum, dopamine, motor function, neurotrophic factors
- MeSH terms
- Animals, Brain, Disease Models, Animal, Male, Parkinson Disease, Secondary, Valproic Acid, Up-Regulation, Oxidopamine, Rats, Sprague-Dawley, Neuroprotective Agents, Brain-Derived Neurotrophic Factor, Rats, Dopaminergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
