The new therapeutic frontier--nuclear receptors and the liver
Abstract
A joint EASL/AASLD Monothematic Conference on 'Nuclear Receptors and Liver Disease' was held from February 27th to March 1st, 2009, in Vienna, Austria, to discuss the latest advances at the forefront of basic and clinical nuclear receptor research and its potential implications for liver diseases. This article reports the highlights of the conference and summarizes the main conclusions emphasizing the relevance for clinical and experimental hepatology. The confluence of nuclear receptors as central transcriptional regulators, acting as sensors and adaptors to many of the small molecules present in the intracellular milieu of all the cells of the liver, provides a current framework to address a broader physiological understanding of the liver. The next stage will be the design and testing of safe and effective therapeutics.
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Nuclear receptors are ligand-activated transcriptional regulators of key metabolic processes including hepatic lipid and glucose metabolism, energy expenditure, bile acid homeostasis, inflammation, fibrosis and cellular proliferation.
“Nuclear (hormone) receptors (NRs) are ligand-activated transcription factors which control a broad spectrum of genes involved in (BA) metabolism, inflammation, cell proliferation and tissue repair including fibrosis (figures 2 and 3)23”
From Novel therapeutic targets for cholestatic and fatty liver disease (2022) · cites this paper as [23]
Bile acid signalling in the liver and gut has broad implications for both cholestatic disorders and NAFLD.
“Thus, BA signalling in the liver and the gut has broad implications for both cholestatic disorders and NAFLD.12 23”
From Novel therapeutic targets for cholestatic and fatty liver disease (2022) · cites this paper as [23]
Nuclear receptors typically induce transcriptional programmes involved in metabolism or transport of the ligand, providing a feedback mechanism to maintain cellular homeostasis.
“NRs typically induce transcriptional programmes involved in metabolism or transport of the ligand, thus providing a feedback mechanism to maintain cellular homoeostasis.23 27”
From Novel therapeutic targets for cholestatic and fatty liver disease (2022) · cites this paper as [23]
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References 63 · Cited by 29
- Authors
- Karpen, S. J., & Trauner, M.
- Affiliations
- Baylor College of Medicine (US)
- Medical University of Graz (AT)
- Corresponding author
- Trauner, Michael
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 52
- Issue
- 3
- Pages
- 455-462
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W1979185230
- Cited by
- 29
- References
- 63
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH
- Falk Foundation
- Austrian Science Foundation (P18613-B05, F3008-B05)
- NIH/NIDDK (DK56239)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- nuclear receptors, liver disease, transcriptional regulation, small molecule detection, drug target design, liver physiology
- MeSH terms
- Humans, Inflammation, Liver, Liver Diseases, Liver Regeneration, Inactivation, Metabolic, Polymorphism, Genetic, Transcription Factors, Receptors, Cytoplasmic and Nuclear, Lipid Metabolism
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