The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Are common factors involved in the pathogenesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma
Open accessAbstract
Background & Aims Well established risk factors for intrahepatic cholangiocarcinoma such as biliary tract inflammation and liver flukes are not present in most patients in Western countries. Although cirrhosis and other causes of chronic liver disease have been implicated, their contribution as risk factors for cholangiocarcinoma is unclear and our aims were to analyze these emerging potential risk factors by systematic examination of case-control series from geographically diverse regions. Methods We performed a literature review and meta-analysis of case-control studies on intrahepatic cholangiocarcinoma and cirrhosis and related risk factors. Tests of heterogeneity, publication bias and sensitivity analyses were performed and an overall odds ratio and 95% confidence intervals calculated. Results Eleven studies from both high and low prevalence regions were identified. All studies except for those evaluating cirrhosis, diabetes, and obesity exhibited significant heterogeneity. Cirrhosis was associated with a combined OR of 22.92 (95% CI = 18.24 – 28.79). Meta-analysis estimated the overall odds ratio (with 95% confidence intervals) for defined risk factors such as hepatitis B: 5.10 (2.91–8.95), hepatitis C: 4.84 (2.41–9.71), obesity: 1.56 (1.26–1.94), diabetes mellitus type II: 1.89 (1.74–2.07), smoking: 1.31 (0.95–1.82), and alcohol use: 2.81 (1.52–5.21). Sensitivity analysis did not alter the odds ratio for any risk factors except smoking and there was no evidence of publication bias. Conclusions Cirrhosis, chronic hepatitis B and C, alcohol use, diabetes, and obesity are major risk factors for intrahepatic cholangiocarcinoma. These data suggest a common pathogenesis of primary intrahepatic epithelial cancers.
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Cites
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Increasing Incidence and Mortality of Primary Intrahepatic Cholangiocarcinoma in the United States
Patel, T. (2001) · Hepatology · doi:10.1053/jhep.2001.25087 · Cited by 1,010
Self-citationRisk factors for cholangiocarcinoma
Tyson, G. L., & El-Serag, H. B. (2011) · Hepatology · doi:10.1002/hep.24351 · Cited by 956
The Continuing Increase in the Incidence of Hepatocellular Carcinoma in the United States: An Update
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Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase?
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Risk factors of intrahepatic cholangiocarcinoma in the United States: A case-control study
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Self-citationPrimary sclerosing cholangitis and ulcerative colitis: Evidence for increased neoplastic potential
Broomé, U., Löfberg, R., Veress, B., & Eriksson, L. S. (1995) · Hepatology · doi:10.1002/hep.1840220511 · Cited by 481
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Burden of liver diseases in the world
Asrani, S. K., Devarbhavi, H., Eaton, J., & Kamath, P. S. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.09.014 · Cited by 3,783
Cholangiocarcinoma — evolving concepts and therapeutic strategies
Ilyas, S. I., Khan, S. A., Hallemeier, C. L., Kelley, R. K., & Gores, G. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.157 · Cited by 1,626
Petrick, J. L., Campbell, P. T., Koshiol, J., Thistle, J. E., Andreotti, G., Beane-Freeman, L. E., Buring, J. E., Chan, A. T., Chong, D. Q., Doody, M. M., et al. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0007-z · Cited by 257
Petrick, J. L., Yang, B., Altekruse, S. F., Van Dyke, A. L., Koshiol, J., Graubard, B. I., & McGlynn, K. A. (2017) · PLOS ONE · doi:10.1371/journal.pone.0186643 · Cited by 210
Proteome Landscapes of Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
Yi, X., Zhu, J., Liu, W., Peng, L., Lu, C., Sun, P., Huang, L., Nie, X., Huang, S., Guo, T., et al. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100604 · Cited by 25
Metadata
- Authors
- Palmer, W. C., & Patel, T.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 57
- Issue
- 1
- Pages
- 69-76
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W1975960651
- Cited by
- 517
- References
- 33
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- green
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