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NKT-cell subsets: Promoters and protectors in inflammatory liver disease
Open accessAbstract
Natural killer T cells (NKT) are innate-like cells which are abundant in liver sinusoids and express the cell surface receptors of NK cells (e.g., NK1.1 (mouse) or CD161+/CD56+(human)) as well as an antigen receptor (TCR) characteristic of conventional T cells. NKT cells recognize lipid antigens in the context of CD1d, a non-polymorphic MHC class I-like molecule. Activation of NKT cells has a profound influence on the immune response against tumors and infectious organisms and in autoimmune diseases. NKT cells can be categorized into at least two distinct subsets: iNKT or type I use a semi-invariant TCR, whereas type II NKT TCRs are more diverse. Recent evidence suggests that NKT-cell subsets can play opposing roles early in non-microbial liver inflammation in that type I NKT are proinflammatory whereas type II NKT cells inhibit type I NKT-mediated liver injury.
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“Another population of immune cells enriched specifically in the liver compartment is the natural killer T cells (NKT).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [86]
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“Liver NKTs have been categorised in two population, type I and type II(86).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [86]
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Research works printed but not linked: 12
- Arrenberg, 2010, Sulfatide-mediated activation of type II natural killer T cells prevents hepatic ischemic reperfusion injury in mice, Gastroenterology, 140, 646, 10.1053/j.gastro.2010.10.003 · DOI
- Halder, 2007, Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease, J Clin Invest, 117, 2302, 10.1172/JCI31602 · DOI
- Deng, 2009, Immature myeloid cells induced by a high-fat diet contribute to liver inflammation, Hepatology, 50, 1412, 10.1002/hep.23148 · DOI
- Syn, 2012, NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease, Gut, 61, 1323, 10.1136/gutjnl-2011-301857 · DOI · Paper page
- Ishikawa, 2011, CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice, J Hepatol, 54, 1195, 10.1016/j.jhep.2010.08.022 · DOI
- Wallace, 2009, NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines, Blood, 114, 667, 10.1182/blood-2009-02-205492 · DOI
- Wu, 2010, Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis, Hepatology, 53, 915, 10.1002/hep.24113 · DOI
- Lukens, 2012, Fat chance: not much against NKT cells, Immunity, 37, 447, 10.1016/j.immuni.2012.09.006 · DOI
- Olszak, 2012, Microbial exposure during early life has persistent effects on natural killer T cell function, Science, 336, 489, 10.1126/science.1219328 · DOI · Paper page
- Girardi, 2012, Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens, Nat Immunol, 13, 851, 10.1038/ni.2371 · DOI
- Alpa, 2008, Anti-neuronal antibodies in patients with HCV-related mixed cryoglobulinemia, Autoimmun Rev, 8, 56, 10.1016/j.autrev.2008.07.027 · DOI
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Horst, A. K., Neumann, K., Diehl, L., & Tiegs, G. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.112 · Cited by 295
Luo, X.-Y., Takahara, T., Kawai, K., Fujino, M., Sugiyama, T., Tsuneyama, K., Tsukada, K., Nakae, S., Zhong, L., & Li, X.-K. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00193.2013 · Cited by 120
Maricic, I., Marrero, I., Eguchi, A., Nakamura, R., Johnson, C. D., Dasgupta, S., Hernandez, C. D., Nguyen, P. S., Swafford, A. D., Knight, R., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800614 · Cited by 92
Self-citationThe liver as a central "hub" of the immune system: pathophysiological implications
Ronca, V., Gerussi, A., Collins, P., Parente, A., Oo, Y. H., & Invernizzi, P. (2025) · Physiological Reviews · doi:10.1152/physrev.00004.2023 · Cited by 59
Metadata
- Authors
- Kumar, V.
- Affiliations
- Torrey Pines Institute For Molecular Studies (US)
- Corresponding author
- Kumar, Vipin
- ORCID
- Kumar, Vipin
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 59
- Issue
- 3
- Pages
- 618-620
- ISSN
- 0168-8278 (ISSN-L)
- PMC
- PMC4086465
- OpenAlex
- W2032607887
- Cited by
- 127
- References
- 0
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 12 · 2023: 8 · 2022: 12 · 2021: 12 · 2020: 12 · 2019: 7 · 2018: 17 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 8 · 2013: 2
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AA020864)
- National Institute on Alcohol Abuse and Alcoholism (R01AA020864)
- National Cancer Institute (R01CA100660)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- NKT cells, inflammatory liver disease, invariant natural killer T cells, type II NKT cells, CD1d, lipid antigen recognition, liver injury, innate immunity, autoimmunity
- MeSH terms
- Animals, Hepatitis, Humans, T-Lymphocyte Subsets, Models, Immunological, Inflammation Mediators, Mice, Natural Killer T-Cells
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- Kumar, V. (2013). NKT-cell subsets: Promoters and protectors in inflammatory liver disease. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2013.02.032
