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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial

Larsen, Fin Stolze, Schmidt, Lars Ebbe, Bernsmeier, Christine, Rasmussen, Allan, Isoniemi, Helena, Patel, Vishal C., Triantafyllou, Evangelos, Bernal, William, Auzinger, Georg, Shawcross, Debbie, Eefsen, Martin, Bjerring, Peter Nissen, Clemmesen, Jens Otto, Hockerstedt, Krister, Frederiksen, Hans-Jørgen, Hansen, Bent Adel, Antoniades, Charalambos G., Wendon, Julia·2016·Journal of Hepatology
DOI 10.1016/j.jhep.2015.08.018
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Abstract

Background & aims Acute liver failure (ALF) often results in cardiovascular instability, renal failure, brain oedema and death either due to irreversible shock, cerebral herniation or development of multiple organ failure. High-volume plasma exchange (HVP), defined as exchange of 8-12 or 15% of ideal body weight with fresh frozen plasma in case series improves systemic, cerebral and splanchnic parameters. Methods In this prospective, randomised, controlled, multicentre trial we randomly assigned 182 patients with ALF to receive either standard medical therapy (SMT; 90 patients) or SMT plus HVP for three days (92 patients). The baseline characteristics of the groups were similar. The primary endpoint was liver transplantation-free survival during hospital stay. Secondary-endpoints included survival after liver transplantation with or without HVP with intention-to-treat analysis. A proof-of-principle study evaluating the effect of HVP on the immune cell function was also undertaken. Results For the entire patient population, overall hospital survival was 58.7% for patients treated with HVP vs. 47.8% for the control group (hazard ratio (HR), with stratification for liver transplantation: 0.56; 95% confidence interval (CI), 0.36-0.86; p=0.0083). HVP prior to transplantation did not improve survival compared with patients who received SMT alone (CI 0.37 to 3.98; p=0.75). The incidence of severe adverse events was similar in the two groups. Systemic inflammatory response syndrome (…

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Crossref · 10.1016/j.jhep.2015.08.018

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  • Studies have suggested that an artificial liver (e.g., plasma replacement therapy or a double plasma molecular absorption system) may improve transplant-free survival.

    “Studies have suggested that an artificial liver (e.g., plasma replacement therapy or a double plasma molecular absorption system) may improve transplant-free survival [218].”

    From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [218]

Citations

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Research works printed but not linked: 34

  1. O’Grady, 1993, Acute liver failure: redefining the syndromes, Lancet, 342, 273, 10.1016/0140-6736(93)91818-7 · DOI
  2. Lee, 2012, Introduction to the revised American Association for the Study of Liver Diseases Position Paper on acute liver failure 2011, Hepatology, 55, 965, 10.1002/hep.25551 · DOI
  3. Chung, 2012, Pathogenesis of liver injury in acute liver failure, Gastroenterology, 143, e1, 10.1053/j.gastro.2012.07.011 · DOI
  4. Rolando, 2000, The systemic inflammatory response syndrome in acute liver failure, Hepatology, 32, 734, 10.1053/jhep.2000.17687 · DOI
  5. Vaquero, 2003, Infection and the progression of hepatic encephalopathy in acute liver failure, Gastroenterology, 125, 755, 10.1016/S0016-5085(03)01051-5 · DOI
  6. Antoniades, 2008, The importance of immune dysfunction in determining outcome in acute liver failure, J Hepatol, 49, 845, 10.1016/j.jhep.2008.08.009 · DOI
  7. Bernuau, 1986, Fulminant and subfulminant liver failure: definitions and causes, Semin Liver Dis, 6, 97, 10.1055/s-2008-1040593 · DOI
  8. O’Grady, 1988, Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure, Gastroenterology, 94, 1192
  9. Saliba, 2013, Albumin dialysis with a noncell artificial liver support device in patients with acute liver failure: a randomized, controlled trial, Ann Intern Med, 159, 522, 10.7326/0003-4819-159-8-201310150-00005 · DOI
  10. Demetriou, 2004, Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure, Ann Surg, 239, 660, 10.1097/01.sla.0000124298.74199.e5 · DOI
  11. Winters, 2012, Plasma exchange: concepts, mechanisms, and an overview of the American Society for Apheresis guidelines, Hematology Am Soc Hematol Educ Program, 2012, 7, 10.1182/asheducation.V2012.1.7.3797920 · DOI
  12. Kondrup, 1992, High volume plasma exchange in fulminant hepatic failure, Int J Artif Organs, 15, 669, 10.1177/039139889201501110 · DOI
  13. Nakamura, 2000, Effect of plasma exchange on serum tissue inhibitor of metalloproteinase 1 and cytokine concentrations in patients with fulminant hepatitis, Blood Purif, 18, 50, 10.1159/000014407 · DOI
  14. Larsen, 1995, Systemic vascular resistance during high volume plasmapheresis in patients with fulminant hepatic failure: relationship with oxygen consumption, Eur J Gastroenterol Hepatol, 7, 892
  15. Larsen, 1996, Cerebral blood flow, oxygen metabolism and transcranial Doppler sonography during high volume plasmapheresis in fulminant hepatic failure, Eur J Gastroenterol Hepatol, 8, 261, 10.1097/00042737-199603000-00014 · DOI
  16. Clemmesen, 2001, Effects of high-volume plasmapheresis on ammonia, urea, and amino acids in patients with acute liver failure, Am J Gastroenterol, 96, 1217, 10.1111/j.1572-0241.2001.03706.x · DOI
  17. Clemmesen, 1999, Hepatic blood flow and splanchnic oxygen consumption in patients with liver failure. Effect of high-volume plasmapheresis, Hepatology, 29, 347, 10.1002/hep.510290206 · DOI
  18. Ferenci, 2002, Hepatic encephalopathy–definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998, Hepatology, 35, 716, 10.1053/jhep.2002.31250 · DOI
  19. Lee, 2009, Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure, Gastroenterology, 137, 856, 10.1053/j.gastro.2009.06.006 · DOI · Paper page
  20. Moreau, 2013, Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis, Gastroenterology, 144, 1426, 10.1053/j.gastro.2013.02.042 · DOI
  21. 1992, American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis, Crit Care Med, 20, 864, 10.1097/00003246-199206000-00025 · DOI
  22. Stravitz, 2013, Role of procoagulant microparticles in mediating complications and outcome of acute liver injury/acute liver failure, Hepatology, 58, 304, 10.1002/hep.26307 · DOI
  23. Levy, 2005, Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: aprospective study, Lancet, 365, 871, 10.1016/S0140-6736(05)71045-X · DOI
  24. Takano, 2010, Protective effect of high-mobility group box 1 blockade on acute liver failure in rats, Shock, 34, 573, 10.1097/SHK.0b013e3181df0433 · DOI
  25. Craig, 2011, Circulating apoptotic and necrotic cell death markers in patients with acute liver injury, Liver Int, 31, 1127, 10.1111/j.1478-3231.2011.02528.x · DOI
  26. Wen, 2013, Circulating histones exacerbate inflammation in mice with acute liver failure, J Cell Biochem, 114, 2384, 10.1002/jcb.24588 · DOI
  27. Selvapatt, 2014, Understanding infection susceptibility in patients with acute-on-chronic liver failure, Intensive Care Med, 40, 1363, 10.1007/s00134-014-3349-x · DOI
  28. Shawcross, 2008, Ammonia impairs neutrophil phagocytic function in liver disease, Hepatology, 48, 1202, 10.1002/hep.22474 · DOI
  29. Taylor, 2013, Circulating neutrophil dysfunction in acute liver failure, Hepatology, 57, 1142, 10.1002/hep.26102 · DOI
  30. Tritto, 2012, Liver replacement therapy, Semin Respir Crit Care Med, 33, 70, 10.1055/s-0032-1301736 · DOI
  31. Murphy, 2004, The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure, Hepatology, 39, 464, 10.1002/hep.20056 · DOI
  32. Bernal, 2007, Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure, Hepatology, 46, 1844, 10.1002/hep.21838 · DOI
  33. Nakae, 2010, Multicenter study of plasma diafiltration in patients with acute liver failure, Ther Apher Dial, 14, 444, 10.1111/j.1744-9987.2010.00864.x · DOI
  34. Antoniades, 2014, Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in paracetamol acetaminophen-induced acute liver failure, Hepatology, 59, 1564, 10.1002/hep.26933 · DOI

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Metadata

Authors
Larsen, F. S., Schmidt, L. E., Bernsmeier, C., Rasmussen, A., Isoniemi, H., Patel, V. C., Triantafyllou, E., Bernal, W., Auzinger, G., Shawcross, D., Eefsen, M., Bjerring, P. N., Clemmesen, J. O., Hockerstedt, K., Frederiksen, H.-J., Hansen, B. A., Antoniades, C. G., & Wendon, J.
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2016-01
Volume
64
Issue
1
Pages
69-78
ISSN
0168-8278
DOI
10.1016/j.jhep.2015.08.018
Cited by
659
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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