The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Role of epithelial to mesenchymal transition in hepatocellular carcinoma
Open accessAbstract
The epithelial to mesenchymal transition (EMT) is a multistep biological process whereby epithelial cells change in plasticity by transient de-differentiation into a mesenchymal phenotype. EMT and its reversal, mesenchymal to epithelial transition (MET), essentially occur during embryogenetic morphogenesis and have been increasingly described in fibrosis and cancer during the last decade. In carcinoma progression, EMT plays a crucial role in early steps of metastasis when cells lose cell-cell contacts due to ablation of E-cadherin and acquire increased motility to spread into surrounding or distant tissues. Epithelial plasticity has become a hot issue in hepatocellular carcinoma (HCC), as strong inducers of EMT such as transforming growth factor-β are able to orchestrate both fibrogenesis and carcinogenesis, showing rising cytokine levels in cirrhosis and late stage HCC. In this review, we consider the significance of EMT-MET in malignant hepatocytes as well as changes in the plasticity of hepatic stellate cells for cellular heterogeneity of HCC, and further aim at explaining the current limiting insights into EMT by snapshot analyses of HCC tissues. Recent advances in the identification of clinically relevant mechanisms that impinge on important EMT-transcription factors, as well as on miRNAs causing EMT signatures and HCC progression are highlighted. In addition, we draw particular attention to framing EMT in the context of potential clinical relevance for HCC patients. We conclude that some aspects of EMT are still elusive and further studies are required to better link the clinical management of HCC with biomarkers and targeted therapies related to EMT.
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1 retracted
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Cited by
Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis
Fabregat, I., & Caballero-Díaz, D. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00357 · Cited by 351
Chen, L., Guo, P., He, Y., Chen, Z., Chen, L., Luo, Y., Qi, L., Liu, Y., Wu, Q., Cui, Y., et al. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0534-9 · Cited by 253
Bárcena‐Varela, M., Caruso, S., Llerena, S., Álvarez‐Sola, G., Uriarte, I., Latasa, M. U., Urtasun, R., Rebouissou, S., Alvarez, L., Jimenez, M., et al. (2019) · Hepatology · doi:10.1002/hep.30168 · Cited by 130
Ribera, J., Pauta, M., Melgar-Lesmes, P., Córdoba, B., Bosch, A., Calvo, M., Rodrigo-Torres, D., Sancho-Bru, P., Mira, A., Jiménez, W., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00428.2016 · Cited by 64
Han, S., Xue, L., Wei, Y., Yong, T., Jia, W., Qi, Y., Luo, Y., Liang, J., Wen, J., Bie, N., et al. (2023) · Advanced Science · doi:10.1002/advs.202207080 · Cited by 24
Metadata
- Authors
- Giannelli, G., Koudelkova, P., Dituri, F., & Mikulits, W.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 65
- Issue
- 4
- Pages
- 798-808
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2407812106
- Cited by
- 615
- References
- 109
- FWCI
- 20.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Giannelli, G., Koudelkova, P., Dituri, F., & Mikulits, W. (2016). Role of epithelial to mesenchymal transition in hepatocellular carcinoma. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2016.05.007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
