The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Acetaminophen (APAP) hepatotoxicity—Isn’t it time for APAP to go away?
Open accessAbstract
Summary Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever around the world. At the same time, APAP is capable of causing dose-related hepatocellular necrosis, responsible for nearly 500 deaths annually in the U.S. alone, as well as 100,000 calls to US Poison Control Centers, 50,000 emergency room visits and 10,000 hospitalizations per year. As an over-the-counter and prescription product (with opioids), APAP toxicity dwarfs all other prescription drugs as a cause for acute liver failure in the United States and Europe, but is not regulated in any significant way. This review will highlight the ongoing controversy as to the proper role for this ubiquitous pain reliever: its history, pathogenesis, clinical challenges in recognition and management, and current regulatory status and propose a new solution to a 50-year-old problem.
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Cites
Increases in drug and opioid-involved overdose deaths – United States, 2010-2015
Rudd, R. A., Seth, P., David, F., & Scholl, L. (2016) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm655051e1 · Cited by 2,194
Acetaminophen Hepatotoxicity in Alcoholics: A Therapeutic Misadventure
SEEFF, L. B., CUCCHERINI, B. A., ZIMMERMAN, H. J., ADLER, E., & BENJAMIN, S. B. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-3-399 · Cited by 424
Acetaminophen Toxicity in an Urban County Hospital
Schiødt, F. V., Rochling, F. A., Casey, D. L., & Lee, W. M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371602 · Cited by 422
Self-citationSelf-harm in England: a tale of three cities: Multicentre study of self-harm
Hawton, K., Bergen, H., Casey, D., Simkin, S., Palmer, B., Cooper, J., Kapur, N., Horrocks, J., House, A., Lilley, R., et al. (2007) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-007-0199-7 · Cited by 419
Acetaminophen Overdose: 662 Cases With Evaluation of Oral Acetylcysteine Treatment
Rumack, B. H. (1981) · Archives of Internal Medicine · doi:10.1001/archinte.1981.00340030112020 · Cited by 350
Cited by
Paracetamol: A Review of Guideline Recommendations
Freo, U., Ruocco, C., Valerio, A., Scagnol, I., & Nisoli, E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153420 · Cited by 208
“Furthermore, drug-induced liver injury is a diagnosis of exclusion that has been ascribed almost only to paracetamol [143].”
BackgroundParacetamol – An old drug with new mechanisms of action
Przybyła, G. W., Szychowski, K. A., & Gmiński, J. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13392 · Cited by 190
Hu, S., Liu, S., Bian, Y., Poddar, M., Singh, S., Cao, C., McGaughey, J., Bell, A., Blazer, L. L., Adams, J. J., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100754 · Cited by 118
Management of Acute Liver Failure: Update 2022
Tujios, S., Stravitz, R. T., & Lee, W. M. (2022) · Seminars in Liver Disease · doi:10.1055/s-0042-1755274 · Cited by 117
Self-citationFoster, A. J., Chouhan, B., Regan, S. L., Rollison, H., Amberntsson, S., Andersson, L. C., Srivastava, A., Darnell, M., Cairns, J., Lazic, S. E., et al. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02427-4 · Cited by 117
Metadata
- Authors
- Lee, W. M.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 67
- Issue
- 6
- Pages
- 1324-1331
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2737518257
- Cited by
- 442
- References
- 5
- FWCI
- 28.56
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
