The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Non-invasive prediction of esophageal varices by stiffness and platelet in non-alcoholic fatty liver disease cirrhosis
Open accessAbstract
Background & aims Baveno VI and expanded Baveno VI criteria can avoid the need for esophagogastroduodenoscopy (EGD) to screen for varices needing treatment (VNT) in a substantial proportion of compensated patients with viral and/or alcoholic cirrhosis. This multicenter, cross-sectional study aims to validate these criteria in patients with compensated cirrhosis due to non-alcoholic fatty liver disease (NAFLD), accounting for possible differences in liver stiffness measurement (LSM) values between M and XL probes.Methods We assessed 790 patients with NAFLD-related compensated cirrhosis who had EGD within six months of a reliable LSM, measured by FibroScan® using M and/or XL probe. Baveno VI and expanded Baveno VI criteria were tested. The main variable used to optimize criteria was the percentage of endoscopies spared, keeping the risk of missing large VNT below a 5% threshold.Results LSM was measured by both M and XL probes (training set) in 314 patients, while only M or XL probe (validation sets) were used to measure LSM in 338 and 138 patients, respectively. In the training set, use of Baveno VI and expanded Baveno VI criteria reduced the number of EGD by 33.3% and by 58%, with 0.9% and 3.8% of large esophageal varices missed, respectively. The best thresholds to rule-out VNT were identified as platelet count >110,000/mm 3 and LSM <30 kPa for M probe, and platelet count >110,000/mm 3 and LSM <25 kPa for XL probe (NAFLD cirrhosis criteria). Thus, usage of NAFLD cirrhosis criteria would have led to an absolute reduction in the number of EGD screened patients of 34.7% and 10.5% with respect to Baveno VI and expanded Baveno VI criteria, respectively.Conclusion The new NAFLD cirrhosis criteria, established for the FibroScan probe, can reduce the use of EGD for screening of VNT in NAFLD cirrhosis by more than half, with a chance of missing VNT below 5%.Lay summary In non-alcoholic fatty liver disease-related compensated cirrhosis, the expanded Baveno VI criteria work better than the Baveno VI criteria for ruling out the presence of varices needing treatment, sparing unnecessary and invasive screening procedures. New diagnostic criteria for this patient group, based on liver stiffness measurement and platelet count, and optimized for the specific FibroScan® probe used, work better than both Baveno VI and expanded Baveno VI criteria. The accuracy of all non-invasive scoring criteria was lower in non-obese patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This notion has been con fi rmed in a multicentre cohort of individuals with MASH-related cirrhosis. 478”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [478]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791
Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781
Expanding consensus in portal hypertension
de Franchis, R. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.05.022 · Cited by 3,078
D'Amico, G., Garcia-Tsao, G., & Pagliaro, L. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2005.10.013 · Cited by 2,687
Wong, R. J., Aguilar, M. E. F., Cheung, R. C., Perumpail, R. B., Harrison, S. A., Younossi, Z. M., & Ahmed, A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.11.039 · Cited by 1,861
Wong, V. W.-S., Vergniol, J., Wong, G. L.-H., Foucher, J., Chan, H. L.-Y., Le Bail, B., Choi, P. C.-L., Kowo, M., Chan, A. W.-H., Merrouche, W., et al. (2010) · Hepatology · doi:10.1002/hep.23312 · Cited by 1,322
Determination of reliability criteria for liver stiffness evaluation by transient elastography
Boursier, J., Zarski, J.-P., de Ledinghen, V., Rousselet, M.-C., Sturm, N., Lebail, B., Fouchard-Hubert, I., Gallois, Y., Oberti, F., Bertrais, S., et al. (2013) · Hepatology · doi:10.1002/hep.25993 · Cited by 662
Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team
Dyson, J., Jaques, B., Chattopadyhay, D., Lochan, R., Graham, J., Das, D., Aslam, T., Patanwala, I., Gaggar, S., Cole, M., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.08.011 · Cited by 603 · cited 1×
“chronic liver disease and cirrhosis [1], an increasing risk factor for hepatocellular carcinoma [2], and the emerging indication for liver transplantation [3].”
Liver Stiffness Measurement Using XL Probe in Patients With Nonalcoholic Fatty Liver Disease
Wong, V. W.-S., Vergniol, J., Wong, G. L.-H., Foucher, J., Chan, A. W.-H., Chermak, F., Choi, P. C.-L., Merrouche, W., Chu, S. H.-T., Pesque, S., et al. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.331 · Cited by 345
Self-citationAugustín, S., Pons, M., Maurice, J. B., Bureau, C., Ştefănescu, H., Ney, M., Blasco, H., Procopeț, B., Tsochatzis, E. A., Westbrook, R., et al. (2017) · Hepatology · doi:10.1002/hep.29363 · Cited by 271
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–139 of 139
Noninvasive diagnosis of liver fibrosis in NAFLD: Tips tricks
Zuberbuhler, F., & Boursier, J. (2019) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2019.03.009 · Cited by 3
Du, Y.-C., Jiang, D., & Wu, J. (2023) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s418892 · Cited by 2
Ahmed, S., Sharma, S., Agarwal, S., Wong, Y. J., Putera, M., & Saraya, A. (2023) · Indian Journal of Gastroenterology · doi:10.1007/s12664-023-01458-1 · Cited by 2
Transient elastography (FibroScan) in critical care: Applications and limitations
Kataria, S., Juneja, D., & Singh, O. (2023) · World Journal of Meta-Analysis · doi:10.13105/wjma.v11.i7.340 · Cited by 2
Fibrosis Assessment in Patients with NAFLD
de Lédinghen, V. (2020) · Springer eBooks · doi:10.1007/978-3-030-40542-7_10 · Cited by 2
Wang, J., Wei, W., Duan, Z., Li, J., Liu, Y., Liu, C., Zhang, L., Zhang, Q., Zhou, S., Zhang, K., et al. (2021) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_22_21 · Cited by 2
Ismail, M. H. (2023) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s410041 · Cited by 2
Rana, A., Malik, A., Krishnan, V., & Thakur, M. B. (2022) · Journal of Clinical Ultrasound · doi:10.1002/jcu.23174 · Cited by 2
Pavlides, M., Mózes, F. E., & Harrison, S. A. (2021) · Gut · doi:10.1136/gutjnl-2021-326313 · Cited by 2
Novel approaches in the medical management of compensated cirrhosis
Moreno-Loro, A., Gallego, Á. G., Jiménez, F., López-Bueno, I., Pérez-Ramírez, A., & Romero‐Gómez, M. (2024) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2024.2358149 · Cited by 1
Wang, J., Tan, S., Zheng, R., Ke, B., Wu, B., & Wu, M. (2025) · Liver Research · doi:10.1016/j.livres.2025.08.002 · Cited by 1
Vashishtha, C., Bhardwaj, A., Laroia, S. T., Prasad, M., Jindal, A., Sharma, M. K., & Sarin, S. K. (2026) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2026.103596 · Cited by 1
Zoughlami, A., Serero, J., Congly, S. E., Zhao, I. X., Zhu, J., Ramji, A. S., Cooper, C., Wong, P. Y. N., Bailey, R. J., Coffin, C. S., et al. (2023) · Canadian Liver Journal · doi:10.3138/canlivj-2022-0047 · Cited by 1
Gao, X., Guo, X., Yang, L., Wei, Z., Zhang, P., Wang, Y., Liu, C.-Y., Zhang, D., & Wang, Y. (2023) · World Journal of Hepatology · doi:10.4254/wjh.v15.i11.1250 · Cited by 1
Diagnosis and Surveillance of Esophageal Varices in Liver Cirrhosis
Biecker, E. (2020) · Springer eBooks · doi:10.1007/978-981-15-7249-4_3 · Cited by 1
Agarwal, S., Sharma, S., Jindal, A., Singh, S., Jagdish, R. K., Gunjan, D., Sarin, S. K., & Saraya, A. (2021) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2021.09.016 · Cited by 1
Non-Invasive Risk Stratification in NAFLD/NASH Patients for Screening EGD
Romano, J., Abdelfattah, T., Manka, P. P., Fuchs, M., & Syn, W.-K. (2022) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s339850 · Cited by 1
Non-invasive Assessment of Non-alcoholic Fatty Liver Disease: Ultrasound and Transient Elastography
Wan, T., & Berzigotti, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-37173-9_7 · Cited by 1
Varices and Screening Endoscopy
Bai, W., & Abraldeṣ, J. G. (2022) · Springer eBooks · doi:10.1007/978-3-031-08552-9_10 · Cited by 1
Individual and population screening of varices needing treatment by a simple, safe and accurate test
Ravaioli, F., Berger, A., Nicoară-Farcău, O., Colecchia, A., Ştefănescu, H., Candillier, C., Nahon, P., Bureau, C., Ganne‐Carrié, N., Berzigotti, A., et al. (2023) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2023.102123 · Cited by 1
Reply to: “Small esophageal varices in compensated cirrhosis patients: To treat or not to treat?”
Wang, H., Wen, B., & Chen, J. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.05.004 · Cited by 1
Petta, S., Sebastiani, G., & de Lédinghen, V. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.08.017
Dong, V. M., Gosselin, M., Jagarlamudi, N., Kok, B., Swain, M. G., Bajaj, J. S., Abraldeṣ, J. G., Marquez, V., Stravitz, R. T., Montaño‐Loza, A. J., et al. (2019) · Canadian Liver Journal · doi:10.3138/canlivj.2019-0011
Elastography in Combination with Other Biomarkers: Role of Algorithms
Thiele, M. S., & Lindvig, K. P. (2020) · Springer eBooks · doi:10.1007/978-3-030-40542-7_48
Liver and Spleen Stiffness to Predict Portal Hypertension and Its Complications
Mendoza, Y. P., Murgia, G., Rodrigues, S. G., Delgado, M., & Berzigotti, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-40542-7_31
Non-invasive Tests, Portal Hypertension, and Beta-blockers: A Step Toward a Greener Environment!
Kulkarni, A. V., & Anand, A. C. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.03.011
Rapport 23-02. Le foie stéatosique non alcoolique : un défi de santé publique
Brissot, P., & Buffet, C. (2023) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2023.03.014
Cueva, C. C. (2022) · Universidad Privada San Juan Bautista · doi:10.59590/upsjb/fcs.med.hum/tesis/4375
СОВРЕМЕННЫЕ ПРИНЦИПЫ ЛЕЧЕНИЯ ЦИРРОЗА ПЕЧЕНИ И ЕГО ОСЛОЖНЕНИЙ
Бедельбаева, Г. Г., Рахметова, В. С., Камалова, Б. Б., Ужегова, Е. Б., & Ердаш, Б. Е. (2024) · Farmaciâ Kazahstana · doi:10.53511/pharmkaz.2024.80.59.001
Koura, M., Zongo-Napon, D. P., Ky, N. M., Kamboulé, E., Ouattara, D. Z., & Sawadogo, A. (2025) · Open Journal of Gastroenterology · doi:10.4236/ojgas.2025.154021
Wada, A., Yamashita, Y., Iguchi, M., Ida, Y., Maekita, T., Ashida, R., & Kitano, M. (2025) · Diagnostics · doi:10.3390/diagnostics15151867
Gao, B., Lin, Y., Zhang, H., Li, Y., Gou, S., Ma, P., Zhao, X., Zhou, Y. F., Chen, Q., Yuan, L., et al. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1647629
Makpu, J. D., Davwar, P., Nyam, D. P., Duguru, M. J., Okwute, A., & Okeke, E. N. (2026) · Gastroenterology Hepatology and Endoscopy Practice · doi:10.4103/ghep.ghep_36_25
Hu, X., Chen, M., Zheng, Y., Yang, X., Zhang, W., Zhang, Y., Yin, Z., Liao, J., Tang, Y., Yu, J., et al. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1707998
Huang, L.-X., & Feng, B. (2026) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v34.i4.318
Papagiouvanni, I., & Tsochatzis, E. A. (2026) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2026.2683676
Sun, Y., Zhao, Y., Zhao, B., Xu, Y., & Chu, H. (2026) · Digestion · doi:10.1159/dig/acmag008
Ahmed, N., Deepika, P. S. V. M., Saini, R., & Sharma, C. (2026) · Journal of Ultrasound · doi:10.1007/s40477-026-01239-4
Metadata
- Authors
- Petta, S., Sebastiani, G., Bugianesi, E., Viganò, M., Wong, V. W.-S., Berzigotti, A., Fracanzani, A. L., Anstee, Q. M., Marra, F., Barbara, M., Calvaruso, V., Cammà, C., Di Marco, V., Craxì, A., & de Ledinghen, V.
- Affiliations
- University of Palermo (IT)
- McGill University Health Centre (CA)
- University of Turin (IT)
- University of Milan (IT)
- Chinese University of Hong Kong (HK)
- University of Bern (CH)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- University of Florence (IT)
- Corresponding author
- Petta, Salvatore
- ORCID
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 69
- Issue
- 4
- Pages
- 878-885
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2804844194
- Cited by
- 140
- References
- 17
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 11 · 2023: 17 · 2022: 17 · 2021: 26 · 2020: 28 · 2019: 21 · 2018: 5
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Bern Open Repository and Information System (University of Bern) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion, other-oa)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by-nc-nd)
- Funders
- European Union (634413)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Keywords
- esophageal varices, compensated cirrhosis, Baveno VI criteria, liver stiffness measurement, FibroScan, platelet count, endoscopy avoidance, non-invasive screening, portal hypertension
- MeSH terms
- Aged, Cross-Sectional Studies, Esophageal and Gastric Varices, Female, Humans, Liver Cirrhosis, Male, Middle Aged, Platelet Count, Endoscopy, Digestive System, Elasticity Imaging Techniques, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
