Cited by 196MicroRNA in disease regulationLiver Disease Diagnosis and TreatmentLiver physiology and pathology

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

MicroRNA-378 promotes hepatic inflammation and fibrosis via modulation of the NF-κB-TNFα pathway

Open access

Zhang, Tianpeng, Hu, Junjie, Wang, Xiaomei, Zhao, Xiaoling, Li, Zhuoyu, Niu, Junqi, Steer, Clifford J., Zheng, Guohua, Song, Guisheng·2019·Journal of Hepatology

DOI 10.1016/j.jhep.2018.08.026PMC PMC6554744

Open this paper in CoChat — free account

Abstract

Background & aims The progression of hepatosteatosis to non-alcoholic steatohepatitis (NASH) is a critical step in the pathogenesis of hepatocellular cancer. However, the underlying mechanism(s) for this progression is essentially unknown. This study was designed to determine the role of miR-378 in regulating NASH progression.Methods We used immunohistochemistry, luciferase assays and immunoblotting to study the role of miR-378 in modulating an inflammatory pathway. Wild-type mice kept on a high-fat diet (HFD) were injected with miR-378 inhibitors or a mini-circle expression system containing miR-378, to study loss and gain-of functions of miR-378.Results MiR-378 expression is increased in livers of dietary obese mice and patients with NASH. Further studies revealed that miR-378 directly targeted Prkag2 that encodes AMP-activated protein kinase γ 2 (AMPKγ2). AMPK signaling negatively regulates the NF-κB-TNFα inflammatory axis by increasing deacetylase activity of sirtuin 1. By targeting Prkag2, miR-378 reduced sirtuin 1 activity and facilitated an inflammatory pathway involving NF-κB-TNFα. In contrast, miR-378 knockdown induced expression of Prkag2, increased sirtuin 1 activity and blocked the NF-κB-TNFα axis. Additionally, knockdown of increased Prkag2 offset the inhibitory effects of miR-378 inhibitor on the NF-κB-TNFα axis, suggesting that AMPK signaling mediates the role of miR-378 in facilitating this inflammatory pathway. Liver-specific expression of miR-378 triggered the development of NASH and fibrosis by activating TNFα signaling. Ablation of TNFα in miR-378-treated mice impaired the ability of miR-378 to facilitate hepatic inflammation and fibrosis, suggesting that TNFα signaling is required for miR-378 to promote NASH.Conclusion MiR-378 plays a key role in the development of hepatic inflammation and fibrosis by positively regulating the NF-κB-TNFα axis. MiR-378 is a potential therapeutic target for the treatment of NASH.Lay summary The recent epidemic of obesity has been associated with a sharp rise in the incidence of non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanism(s) remains poorly described and effective therapeutic approaches against NAFLD are lacking. The results establish that microRNA-378 facilitates the development of hepatic inflammation and fibrosis and suggests the therapeutic potential of microRNA-378 inhibitor for the treatment of NAFLD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jhep.2018.08.026

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Untitled work
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
Younossi, Z., Anstee, Q. M., Marietti, M., Hardy, T., Henry, L., Eslam, M., George, J., & Bugianesi, E. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.109 · Cited by 5,249
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Mihaylova, M. M., & Shaw, R. J. (2011) · Nature Cell Biology · doi:10.1038/ncb2329 · Cited by 2,923
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750
Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening
Ratziu, V., Harrison, S. A., Francque, S., Bedossa, P., Lehert, P., Serfaty, L., Romero-Gomez, M., Boursier, J., Abdelmalek, M., Caldwell, S., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.01.038 · Cited by 1,035
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
Rolo, A. P., Teodoro, J. S., & Palmeira, C. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.003 · Cited by 955
Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis
Tiniakos, D. G., Vos, M. B., & Brunt, E. M. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102132 · Cited by 870

Show all 43 references

Research works printed but not linked: 1

Foog, 2017, Managing HCC in NAFLD. Curr Hepatol, Rep, 16, 374

Sorted by citations

Items 101–196 of 196

Dachengqi decoction ameliorated liver injury in liver fibrosis mice by maintaining gut vascular barrier integrity
Shuhan, W., Li, J.-X., Shang, L., Liuying, C., Fangyuan, Z., Mengqi, Z., Qifeng, L., Yuju, C., Junli, Z., Yao, W., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156272 · Cited by 12
Comprehensive profiling of serum microRNAs in normal and non-alcoholic fatty liver disease (NAFLD) patients
Zhang, J., Ullah, K., Khan, N., & Pan, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-87791-1 · Cited by 12
Activation of dsRNA-Dependent Protein Kinase R by MicroRNA-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance
Wang, H., Song, Y., Wu, Y., Kumar, V., Mahato, R. I., & Su, Q. (2021) · Diabetes · doi:10.2337/20-0181 · Cited by 12
MiR-378b Modulates Chlamydia-Induced Upper Genital Tract Pathology
Lundy, S. R., Abney, K., Ellerson, D., Igietseme, J. U., Carroll, D. S., Eko, F. O., & Omosun, Y. (2021) · Pathogens · doi:10.3390/pathogens10050566 · Cited by 12
MiR-4465-modified mesenchymal stem cell-derived small extracellular vesicles inhibit liver fibrosis development via targeting LOXL2 expression
Wang, Y., Chen, Y., Yang, F., Yu, X., Chu, Y., Zhou, J., Yan, Y., & Xi, J. (2024) · Journal of Zhejiang University-SCIENCE B · doi:10.1631/jzus.b2300305 · Cited by 11
A role for curcumin in preventing liver fibrosis in animals: a systematic review and meta-analysis
Huang, B.-H., Guo, Z., Lv, B., Zhao, X., Li, Y., & Lv, W. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1396834 · Cited by 14
Self-citation
The role of glucosylceramide and glucosylceramide synthase in liver disease: from bench to bedside
Gan, J., Zheng, S. J., Mao, X. R., & Li, J. F. (2020) · Acta Biochimica Polonica · doi:10.18388/abp.2020_5478 · Cited by 11
Obesity-Induced Upregulation of microRNA-183-5p Promotes Hepatic Triglyceride Accumulation by Targeting the B-Cell Translocation Gene 1
Zhou, X., Yuan, Y., Teng, F., Li, K., Luo, S., Zhang, P., Liu, D., Zhang, H., & Zhang, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.119011 · Cited by 11
Network pharmacology analysis on mechanism of Jian Pi Qing Gan Yin decoction ameliorating high fat diet-induced non-alcoholic fatty liver disease and validated in vivo
Liu, W., Shang, J., Deng, Y., Han, X., Chen, Y., Wang, S., Yang, R., Dong, F., & Shang, H. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115382 · Cited by 11
Phosphatidylethanolamine-binding protein 4 deficiency exacerbates carbon tetrachloride-induced liver fibrosis by regulating the NF-κB signaling pathway
Luo, Q., Ling, Y., Li, Y., Qu, X., Shi, Q.-Q., Zheng, S., Li, Y., Huang, Y., & Zhou, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.964829 · Cited by 11
MicroRNA-29b ameliorates hepatic inflammation via suppression of STAT3 in alcohol-associated liver disease
Zhou, K., Yin, F., Li, Y., Ma, C., Liu, P., Xin, Z., Ren, R., Wei, S., Khan, M. B., Wang, H., et al. (2021) · Alcohol · doi:10.1016/j.alcohol.2021.10.003 · Cited by 11
miR-378 influences muscle satellite cells and enhances adipogenic potential of fibro-adipogenic progenitors but does not affect muscle regeneration in the glycerol-induced injury model
Mucha, O., Podkalicka, P., Żukowska, M., Pośpiech, E., Dulak, J., & Łoboda, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-40729-x · Cited by 9
Clinical and pathological characteristics of metabolic dysfunction-associated steatotic liver disease and the key role of epigenetic regulation: implications for molecular mechanism and treatment
Li, Y., Li, L., Zhang, Y., Lü, J., Tang, X., Bi, C., Qu, Y., & Chai, J. (2025) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188251321602 · Cited by 13
Progress and prospect of minicircle as a minimized non-viral DNA vector in gene therapy and regenerative medicine
Chanani, P., Rezaei, N., Dormiani, K., Shokatian, M., & Ata-abadi, N. S. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102682 · Cited by 13
MicroRNA-339-5p inhibits lipopolysaccharide-induced rat mesangial cells by regulating the Syk/Ras/c-Fos pathway
Gao, J., Shi, M. M., Jiang, H., Zhu, X. L., Wei, L. B., & Qin, X. J. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02261-z · Cited by 10
Nonalcoholic Fatty Liver Disease and MicroRNAs
Mishra, S., Sarangi, R., Das, S., & Mishra, A. (2023) · Biomedical and Biotechnology Research Journal (BBRJ) · doi:10.4103/bbrj.bbrj_319_22 · Cited by 10
Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice
Wang, B., Kaufmann, B. K., Mogler, C., Zhong, S., Yin, Y., Cheng, Z., Schmid, R. M., Friess, H., Hüser, N., von Figura, G., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0294257 · Cited by 10
AMPK/Sirt1-mediated inflammation is positively correlated with myocardial fibrosis during ageing
Song, Y., Zhang, Y., Zhang, X., Hu, S., Wang, J., Deng, G., & Zhou, Z. (2022) · Acta cardiologica. Supplementum · doi:10.1080/00015385.2022.2119667 · Cited by 10
Noncoding RNA network crosstalk in organ fibrosis
Ling, H., Wang, X.-C., Liu, Z., Mao, S., Yang, J., Sha, J.-M., & Tao, H. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111430 · Cited by 8
Self-citation
Integrated Analysis of Hepatic miRNA and mRNA Expression Profiles in the Spontaneous Reversal Process of Liver Fibrosis
Tai, Y., Zhao, C., Lan, T., Zhang, L., Xiao, Y., Tong, H., Liu, R., Tang, C., & Gao, J. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.706341 · Cited by 9
Investigation of the Potential Mechanism of Danggui Shaoyao San for the Treatment of Non-alcoholic Fatty Liver Disease (NAFLD) with Network Pharmacology and Molecular Docking
Zeng, F., Zhang, Y., Cheng, F., Li, Q., & Wang, J. (2022) · Current Computer - Aided Drug Design · doi:10.2174/1573409918666220815093324 · Cited by 9
m6A modification in non-coding RNAs: Mechanisms and potential therapeutic implications in fibrosis
Zhou, Y., Jian, N., Jiang, C., & Wang, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117331 · Cited by 11
MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation
Valacchi, G., Pambianchi, E., Coco, S., Pulliero, A., & Izzotti, A. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12020176 · Cited by 9
MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes
Ma, N., Hou, A., Pan, X., Sun, F., Xu, X., Yu, C., Lai, R., Huang, R., Gong, L., Xie, Q. M., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.80760 · Cited by 8
Interactive effects of cadmium and titanium dioxide nanoparticles on hepatic tissue in rats: Ameliorative role of coenzyme 10 via modulation of the NF-κB and TNFα pathway
Abd‐Elhakim, Y. M., Hashem, M. M., Abo‐EL‐Sooud, K., Mousa, M. R., Soliman, A., Mouneir, S. M., Ismail, S. H., Hassan, B. A., & El-Nour, H. H. M. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.114191 · Cited by 8
Invariant natural killer T cells: Not to be ignored in liver disease
Gan, J., Mao, X. R., Zheng, S. J., & Li, J. F. (2021) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12968 · Cited by 8
Effects of vitamin D deficiency on chronic alcoholic liver injury
Wang, H., Gong, W., Gao, J., Cheng, W., Hu, Y.-D., & Hu, C. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.08.037 · Cited by 7
Molecular Clustering of Metabolic Dysfunction-Associated Steatotic Liver Disease Based on Transcriptome Analysis
Ryu, G., Yoon, E. L., Kim, W., & Jun, D. W. (2025) · Diagnostics · doi:10.3390/diagnostics15030342 · Cited by 7
TNFα-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity
Yang, H., Zhao, X., Liu, J., Jin, M., Liu, X., Yan, J., Yao, X., Mao, X., Li, N., Liang, B., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02528-y · Cited by 7
Self-citation
Epigenetic changes induced by pathogenic Chlamydia spp
Stein, R. A., & Thompson, L. M. (2023) · Pathogens and Disease · doi:10.1093/femspd/ftad034 · Cited by 10
Glucosylceramide synthase regulates hepatocyte repair after concanavalin A-induced immune-mediated liver injury
Gan, J., Gao, Q. F., Wang, L., Tian, A. P., Zhu, L. D., Zhang, L. T., Zhou, W., Mao, X. R., & Li, J. F. (2021) · PeerJ · doi:10.7717/peerj.12138 · Cited by 7
MicroRNA-137-3p Improves Nonalcoholic Fatty Liver Disease through Activating AMPKα
Yu, Y., He, C., Tan, S., Huang, M., Guo, Y., Li, M., & Zhang, Q. (2021) · Analytical Cellular Pathology · doi:10.1155/2021/4853355 · Cited by 7
miRNAs, lncRNAs, circRNAs and piRNAs in Nonalcoholic Fatty Liver Disease: Past, Present and Future
Lucaciu, R. L., Orasan, O. H., Hangan, A. C., Iancu, M., Cozma, A., Coste, S. C., Gog-Bogdan, S., Sevastre, B., & Procopciuc, L. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110402 · Cited by 7
RETRACTED ARTICLE: Ameliorative potentials of Persea americana leaf extract on toxicants - induced oxidative assault in multiple organs of wistar albino rat
Ogunmoyole, T., Dada, I., & Adebamigbe, O. A. (2021) · Clinical Phytoscience · doi:10.1186/s40816-020-00237-1 · Cited by 9
Retracted
Perspectives of bovine and human milk exosomics as health biomarkers for advancing systemic therapeutic potential
Mahala, S., Rai, S., Singh, A., Mehrotra, A., Pandey, H. O., & Kumar, A. (2021) · Food Biotechnology · doi:10.1080/08905436.2021.1979033 · Cited by 6
The macrophage-associated microRNA-4715-3p / Gasdermin D axis potentially indicates fibrosis progression in nonalcoholic fatty liver disease: evidence from transcriptome and biological data
Chen, S., Cai, X., Liu, Y., Shen, Y. L., Guillot, A., Tacke, F., Tang, L., & Liu, H. (2022) · Bioengineered · doi:10.1080/21655979.2022.2072602 · Cited by 6
Relaxin in fibrotic ligament diseases: Its regulatory role and mechanism
Yuan, S., Guo, D., Liang, X., Zhang, L., Zhang, Q., & Xie, D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1131481 · Cited by 6
Exosome-associated miRNA-99a-5p targeting BMPR2 promotes hepatocyte apoptosis during the process of hepatic fibrosis
Li, F., Yan, T., Wang, S., & Wen, X. (2023) · Clinical and Experimental Medicine · doi:10.1007/s10238-023-01122-0 · Cited by 8
Elevated miR-34a induced by lipotoxicity and inflammation mediates pathophysiological communication between hepatocytes and hepatic stellate cells in liver fibrosis
Duan, Q., Hu, R., Chen, Y., Wade, H., Kaluzny, S., Zhang, B., Wu, R., Liu, G., Wang, C., Harris, E. N., et al. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101648 · Cited by 7
Comparative Analysis of Gene and MicroRNA Expression in Subcutaneous Adipose Tissue in Metabolically Healthy and Unhealthy Obesity
Markina, N. O., Matveev, G. A., Zasypkina, K. A., Khromova, N. V., Babenko, A. Y., & Shlyakhto, E. V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178212 · Cited by 5
MASLD Under the Microscope: How microRNAs and Microbiota Shape Hepatic Metabolic Disease Progression
Asero, C., Franzè, M. S., Cacciola, I., & Gangemi, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178633 · Cited by 6
MicroRNAs as serum biomarker for Senecio brasiliensis poisoning in cattle
Winter, E., Cisilotto, J., Goetten, A. L. F., Veiga, Â. P. M., Ramos, A. T., Zimermann, F. C., Reck, C., & Creczynski‐Pasa, T. B. (2022) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2022.103906 · Cited by 5
Integrated bioinformatics analysis reveals potential mechanisms associated with intestinal flora intervention in nonalcoholic fatty liver disease
Liu, Y., Liu, X., Zhou, W., Zhang, J., Wu, J., Guo, S., Jia, S., Wang, H., Li, J., & Tan, Y. (2022) · Medicine · doi:10.1097/md.0000000000030184 · Cited by 5
Identification and Validation of Autophagy-Related Gene Nomograms to Predict the Prognostic Value of Patients with Cervical Cancer
Jiang, J., Xu, H., Wang, Y., & Lü, H. (2021) · Journal of Oncology · doi:10.1155/2021/5583400 · Cited by 5
Noncoding RNA-Mediated Epigenetic Regulation in Hepatic Stellate Cells of Liver Fibrosis
Gao, R., & Mao, J. (2024) · Non-Coding RNA · doi:10.3390/ncrna10040044 · Cited by 4
Network pharmacology and bioinformatics analysis reveals: NXC improves cardiac lymphangiogenesis through miR-126-3p/SPRED1 regulating the VEGF-C axis to ameliorate post-myocardial infarction heart failure
Xu, J., Wang, C., Xu, Y., Wang, H.-C., & Wang, X. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119959 · Cited by 5
Self-citation
MicroRNAs as critical regulators in liver fibrosis
Wang, X., Zai, Q., He, Y., & Xie, Q. (2023) · Portal hypertension & cirrhosis · doi:10.1002/poh2.56 · Cited by 4
Self-citation
Evaluation of the Mechanism of Modified Lingguizhugan Decoction in the Treatment of Nonalcoholic Fatty Liver Disease
Yang, F., Zhou, J., Su, B., Zhang, Q., Luo, X., Wang, F., Huang, J., & Huang, W. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4576679 · Cited by 4
Kupffer cells and liver
Hossen, M. J., Matin, M. A., Sikder, M. H., Ahmed, M. S., & Rahman, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822368-0.00016-5 · Cited by 4
Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia
Florczyk, U., Polak, K., Sabo, R., Martyniak, A., Stępniewski, J., & Dulak, J. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00535-8 · Cited by 4
Short-term high-fat diet feeding plus acute ethanol binge induced acute liver injury in mice via oxidative stress, inflammation and pyroptosis
Deng, Y., Chen, X., Guo, W., Chen, Y., Xu, L., Suo, W., Liu, W., Dai, J., Wang, K., Li, Q., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1602280 · Cited by 3
Pigment epithelium-derived factor prevents endothelial dysfunction in early stage of hyperlipidemia by regulating endothelial fatty acid transport
Wang, H., Shen, C., Yang, Y., Li, X., Tan, J. H., Yang, M. W. O., Wu, Y., Li, Y., Feng, Z., Gao, S., et al. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120446 · Cited by 3
Isolation of Mitochondria from Liver and Extraction of Total RNA and Protein: Analyses of miRNA and Protein Expression
Simão, A. L., Borralho, P. M., Steer, C. J., Castro, R. E., & Rodrigues, C. M. P. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1433-4_1 · Cited by 3
Self-citation
Targeting non-coding RNAs and N6-methyladenosine modification in hepatocellular carcinoma
Wu, L., Zhang, Y., & Ren, J. T. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116153 · Cited by 3
1-phenyl-3-methyl-5-pyrazolone activates the AMPK pathway to alleviate western-diet induced metabolic dysfunction-associated steatohepatitis in mice
Chen, X., Huang, J., You, Y., Xue, H., Wu, L., Zeng, D., Xing, Q., Wu, M., Wang, M.-F., Pan, J., et al. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2024.12.033 · Cited by 3
Mechanistic insight into the hepatoprotective effect of Moringa oleifera Lam leaf extract and telmisartan against carbon tetrachloride-induced liver fibrosis: plausible roles of TGF-β1/SMAD3/SMAD7 and HDAC2/NF-κB/PPARγ pathways
Baky, N. A. A., Fouad, L. A., Ahmed, K. A., & Alzokaky, A. A. (2024) · Drug and Chemical Toxicology · doi:10.1080/01480545.2024.2358066 · Cited by 2
Influenza-induced microRNA-155 expression is altered in extracellular vesicles derived from the COPD epithelium
Reid, L. V., Spalluto, C. M., Wilkinson, T. M. A., & Staples, K. J. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1560700 · Cited by 2
Non-invasive biomarkers for monitoring portal hypertension in metabolic dysfunction-associated steatotic liver disease (MASLD)
Pal, S. C., Ramírez-Mejía, M. M., Keaveny, A. P., & Méndez‐Sánchez, N. (2025) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2025.2548526 · Cited by 3
Gallic acid ameliorates diabetic steatohepatitis in db/db mice fed with a high-fat diet
Wang, C., Tsai, M., Chang, Y.-C., Yang, C.-H., Tsai, I.-N., Yang, M., & Wang, C.-J. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101553 · Cited by 2
Morphological evaluation of the effects of ursodeoxycholic acid on muscular layer of the gallbladder wall of the mice
Абатуров, А. Е., Babуch, V. L., Bondarenko, N. S., Bondarenko, O. O., Лєвих, А. Е., & Твердохліб, І. В. (2020) · Morphologia · doi:10.26641/1997-9665.2020.2.7-16 · Cited by 2
Non-Coding RNAs Involved in the Regulation of Signaling Pathways as Possible Markers of Non-Alcoholic Fatty Liver Disease Progression
Topchieva, L. V., Валерьевна, К. И., Дуданова, О. П., Vasilyeva, A. V., & Жулай, Г. А. (2024) · Biology Bulletin · doi:10.1134/s1062359024607742 · Cited by 1
MicroRNA: A Novel Class of Potential Biomarkers and Therapeutic Target for Non-Alcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Bhattacharya, I., Arumugam, S., Maity, D. K., Kumar, A., Bhattacharya, T., Sahu, A., & Sreedhar, R. (2025) · MicroRNA · doi:10.2174/0122115366364599250604050335 · Cited by 4
Pemafibrate Ameliorates Steatotic Liver Disease Regardless of Endothelial Dysfunction in Mice
Hara, T., Yamagami, H., Uemoto, R., Sekine, A., Kaneko, Y., Miyataka, K., Hori, T., Ichimura‐Shimizu, M., Funamoto, M., Harada, T., et al. (2025) · Antioxidants · doi:10.3390/antiox14070891 · Cited by 1
Serum soluble ASGR1 concentration is elevated in patients with metabolic dysfunction-associated steatotic liver disease and is associated with adiponectin
Wang, J.-M., Jiang, L.-Y., Deng, Y.-T., Li, J.-Y., Sun, H., Ran, L., & Xiao, X. (2026) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2025-005638 · Cited by 1
Progression of liver injury and apoptosis in small yellow croaker (Larimichthys polyactis) during Pseudomonas plecoglossicida infection
Zhu, J., Zhang, T., Liu, S., Ye, T., Chen, H., Liang, X. H., Guo, D., Zhu, J., Lou, B., & Liu, F. (2026) · Aquaculture · doi:10.1016/j.aquaculture.2026.743931 · Cited by 1
Self-citation
MicroRNA–SIRT1 crosstalk in liver diseases: molecular regulation of metabolism, inflammation, and cell survival
El‐Sehrawy, A. A. M. A., Radhie, S. H., Baig, M. R., Mansurov, D., Rekha, M. M., Nayak, P. P., Bainsal, N., Singhal, D., Smerat, A., & Alnajar, M. J. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12062-9 · Cited by 1
Nuclear transcription factor kB (NF-kB) activity in lymphocyte populations in children with Wilson-Konovalov disease
Курбатова, О. В., Петричук, С. В., Купцова, Д. Г., Movsisyan, G. B., Радыгина, Т. В., Komarova, A. D., Олегович, А. А., Freidlin, E. V., Semikina, E. L., Потапов, А. С., et al. (2023) · Medical Immunology (Russia) · doi:10.15789/1563-0625-ntf-2799 · Cited by 1
Identification of biomarkers associated with immune-propionate metabolism in nonalcoholic fatty liver disease
Qu, S., Huang, H. F., Diao, Y., Liu, B., Tang, B., Huo, S., Yu, L., Xuan, X., Mou, W., Liu, P., et al. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.10.38 · Cited by 1
Exploring Mechanisms of Lang Qing Ata in Non-Alcoholic Steatohepatitis Based on Metabolomics, Network Pharmacological Analysis, and Experimental Validation
Li, S., Zhu, H., Zhai, Q., Hou, Y., Yang, Y., Lan, H., Jiang, M., & Xuan, J. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s503757 · Cited by 1
Advances of microRNAs in regulating mitochondrial function: new potential application in NAFLD treatment
Yu, C., Chen, J., & Ren, J. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07503-0 · Cited by 1
Integrated Analysis of miRNA-mRNA Expression in Mink Lung Epithelial Cells Infected With Canine Distemper Virus
Chen, Q., Tong, M., Sun, N., Yang, Y., Cheng, Y., Li, Y., Wang, G., Cao, Z., Zhao, Q., & Cheng, S. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.897740 · Cited by 1
Real-world Effectiveness of Glecaprevir/Pibrentasvir (GLE/PIB) for Chronic Hepatitis C Infection: Evidence From a German Single-center Cohort Study
Beisel, C., Herrmann, M., Piecha, F., Lampalzer, S., Buescher, G., Pischke, S., & Wiesch, J. S. Z. (2021) · Hepatitis Monthly · doi:10.5812/hepatmon.110077
BCAT1 Promotes Lung Adenocarcinoma Progression Through Enhanced Mitochondrial Respiration and NF-κB Pathway ActivationPreprint
Yu, M., Zhao, Q., Li, J., Xu, F., Zhang, Z., Liu, Y., Dai, L., Zhang, B., Zhang, J., & Zhang, J. (2021) · Research Square · doi:10.21203/rs.3.rs-604725/v1
MicroRNA targeted therapy in hepatitis
Lu, X., & Wang, F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89774-7.00009-1
Exosomal miR-378a-3p derived from keratinocytes inhibits transforming growth factor beta-induced fibroblast activation and attenuates bleomycin-induced skin fibrosisPreprint
Yang, L., Tian, G., Liu, B., Li, C., Bo, Y., Si, J., Zhang, L., & Yan, Y. C. (2024) · Research Square · doi:10.21203/rs.3.rs-3829723/v1
NAFLD PATHOGENESIS AND CLINICAL ASSOCIATIONS WITH CARDIOVASCULAR DISEASES
Valaitienė, J. (2024) · Health Sciences · doi:10.35988/sm-hs.2024.129
Upregulation of serum miR 155 and miR 30c as a Potential Biomarker for Alzheimer’s DiseasePreprint
Kafshdooz, T., Farajnia, S., Sharifi, R., Najmi, S., & Pourseif, M. M. (2024) · Research Square · doi:10.21203/rs.3.rs-4495031/v1
Charnolosome in hepatic diseases
Sharma, S. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21752-4.00031-6
Obesity and noncoding RNAs in epigenetic inheritance of metabolic disease
Zhang, Q., Ren, Y., Wu, Y., & Zeng, Y. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18979-1.00010-1
GABPα targeted by miR-378a-5p inhibits the growth and angiogenesis of colorectal carcinoma
Wang, M., Qi, J., Tan, Z., Zhou, R., Zhuo, Q., Deng, X., Wang, Z., Zhou, R., Li, F., & Xu, Y. (2024) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2024.106729
Non-coding RNAs involved in the regulation of signaling pathways as possible markers of non-alcoholic fatty liver disease progression
Topchieva, L., Жулай, Г. А., Валерьевна, К. И., Дуданова, О. П., & Vasilyeva, A. V. (2024) · Известия Российской академии наук Серия биологическая · doi:10.31857/s1026347024050023
miR-378, miR-20a, and miR-520a-3p can be used in a novel serum prognostic panel for cervical cancer
Li, S., Li, H., Li, Y., & Cui, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-20338-6
Additional file 1 of Obesity-induced downregulation of miR-192 exacerbates lipopolysaccharide-induced acute lung injury by promoting macrophage activation
Wu, S., Tang, W., Liu, L., Wei, K., Tang, Y., Ma, J., Li, H., & Ao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.25414851
Nobiletin Attenuates Adipogenesis and Promotes Browning in 3T3-L1 Adipocytes Through Exosomal miRNA-Mediated AMPK Activation
Chauhan, S., Baek, H., Jaiswal, V. K., Park, M., & Lee, H. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb48010036
MiR‐18a‐5p Attenuates Oxidative Stress and Inhibits Lipid Accumulation in Alcoholic Fatty Liver by Activating the CYP1A1‐PPAR Axis
Zhang, X., Li, W., Ullah, U., Li, N., Geng, X., Qi, J., Chen, H., Zhang, X., Hu, Y., Yang, L., et al. (2026) · Immunity Inflammation and Disease · doi:10.1002/iid3.70350
Circulating miR-378a-3p attenuates pulmonary inflammation and fibrosis via BAT-lung crosstalk
He, R., Peng, X., Pan, R., Kang, Q., Liu, S., Yang, M., Wang, Z., Deng, H., Li, D., Xie, Y., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04296-3
The Theragnostic Role of Mesenchymal Stem Cells-Derived Extracellular Vesicles in Hepatocellular Carcinoma Management
Salah, R. A., Shouman, S., Abouzid, A. E., Ehab, S., El-Qassas, J., Mohamed, A., & El‐Badri, N. (2026) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-032-12705-1_11
CircClint1/miR-378b/NPDC1 axis: A novel therapeutic target and biomarker for myocardial infarction
Zhang, X., Zhu, X., DANG, Z., Chen, M., Tian, J., Guo, X., Guo, R., Han, C., Shen, N., Li, X., et al. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124447
Non-coding RNA networks in metabolic dysfunction-associated steatotic liver disease: Mechanisms and therapeutic perspectives
Ren, R., Ren, S., Xu, Y., Xiao, L., & Wei, X. (2026) · Liver Research · doi:10.1016/j.livres.2026.05.002
Curcumin and curcumin nanoparticles attenuate oxidative stress, improve lipid profile, and protect liver and kidney functions and histology from instant noodles-induced damage
Okail, H., Helmy, R. M., Soliman, H. A. M., Ashry, A., Ahmed, F. E.-Z. A., & Hassanein, H. M. A. (2026) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-026-04683-2
Harnessing Natural Products as AMPK Activators: A Promising Therapeutic Avenue for Metabolic Dysfunction-Associated Steatotic Liver Disease
Wang, K., Shen, H., Shi, J., & Fu, J. (2026) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-026-00766-9 · Cited by 1
Screening alcohol-degrading lactic acid bacteria in vitro and its protective effect against hepatic steatosis in chronic alcohol-exposed mice via AMPK-CPT1A pathway
Wu, J., Cai, Y., Liu, Y., Ma, Z., & Wang, R. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109711
Mitochondrial nanomotors prevent the progression of liver fibrosis
Chen, L., Lin, X., Wang, K., Duan, Y., Wu, Z., Wu, Z., Zhou, M., Mao, C., & Wan, M. (2026) · Science China Chemistry · doi:10.1007/s11426-025-3433-0
Sirtuin signaling as therapeutic targets of immunosenescence
Calabrò, A., Accardi, G., Aiello, A., Caruso, C., Galimberti, D., Puleo, C., Zarcone, R., & Candore, G. (2026) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2026.2737637
Epigenetic Signatures Guiding Predictive, Preventive, and Personalized Medicine (3PM) for Metabolic Diseases
Ng, R. R., Gao, Y., Xu, Y., & Lau, A. T. Y. (2026) · Advances in predictive, preventive and personalised medicine · doi:10.1007/978-3-032-32838-0_4
The AMPK signaling pathway in cell metabolism and human diseases
Zhang, Z., Gu, Y., He, H., Qiao, S., Shao, Y., 龙先铭, Huang, J., Zhang, L., & Zhou, F. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02790-6

Authors: Zhang, T., Hu, J., Wang, X., Zhao, X., Li, Z., Niu, J., Steer, C. J., Zheng, G., & Song, G.
Affiliations: University of Minnesota (US)
Hubei University of Chinese Medicine (CN)
Jilin University (CN)
Shanxi University (CN)
Corresponding author: Zheng, Guohua
Song, Guisheng
ORCID: Zhang, Tianpeng
Hu, Junjie
Wang, Xiaomei
Zhao, Xiaoling
Li, Zhuoyu
Niu, Junqi
Steer, Clifford J.
Song, Guisheng
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 2019-01
Volume: 70
Issue: 1
Pages: 87-96
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/j.jhep.2018.08.026
PMC: PMC6554744
OpenAlex: W2890391525
Cited by: 196
References: 43
Citations by year: 2026: 15 · 2025: 23 · 2024: 34 · 2023: 23 · 2022: 37 · 2021: 43 · 2020: 14 · 2019: 7
FWCI: 4.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Hepatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (R01 DK102601)
American Cancer Society (ISG-16-210-01-RMC)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: miR-378, nonalcoholic steatohepatitis, liver inflammation, liver fibrosis, NF-κB signaling, TNF signaling, PRKAG2, AMPK, SIRT1, obesity, high-fat diet, microRNA, therapeutic target, hepatocellular carcinoma risk, liver-specific gene expression
MeSH terms: Animals, Biopsy, Disease Models, Animal, Gene Expression Regulation, Hepatitis, Humans, Immunohistochemistry, Liver, Liver Cirrhosis, Male, Mice, Inbred C57BL, Tumor Necrosis Factor-alpha, Immunoblotting, Signal Transduction, NF-kappa B, Disease Progression, MicroRNAs, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

MicroRNA-378 promotes hepatic inflammation and fibrosis via modulation of the NF-κB-TNFα pathway

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks