Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease

Luukkonen, Panu K.; Qadri, Sami; Ahlholm, Noora; Porthan, Kimmo; Männistö, Ville; Sammalkorpi, Henna; Penttilä, Anne K.; Hakkarainen, Antti; Lehtimäki, Tiina E.; Gaggini, Melania; Gastaldelli, Amalia; Ala-Korpela, Mika; Orho-Melander, Marju; Arola, Johanna; Juuti, Anne; Pihlajamäki, Jussi; Hodson, Leanne; Yki-Järvinen, Hannele

doi:10.1016/j.jhep.2021.10.013

Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease

Background & Aims There is substantial inter-individual variability in the risk of non-alcoholic fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR) (‘MetComp’) and part by common modifiers of genetic risk (‘GenComp’). We examined how IR on the one hand and genetic …