Promises of microbiome-based therapies
Open accessAbstract
Humans harbour large quantities of microbes, including bacteria, fungi, viruses and archaea, in the gut. Patients with liver disease exhibit changes in the intestinal microbiota and gut barrier dysfunction. Preclinical models demonstrate the importance of the gut microbiota in the pathogenesis of various liver diseases. In this review, we discuss how manipulation of the gut microbiota can be used as a novel treatment approach for liver disease. We summarise current data on untargeted approaches, including probiotics and faecal microbiota transplantation, and precision microbiome-centered therapies, including engineered bacteria, postbiotics and phages, for the treatment of liver diseases.
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Precision microbiome-centred therapies may provide a promising avenue for more individualised treatment of inflammation in NAFLD.
“Precision microbiome-centred therapies, including engineered bacteria, postbiotics and phages, may provide a promising avenue for the more individualised treatment of inflammation in NAFLD.44”
From An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH (2023) · cites this paper as [44]
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References 124 · Cited by 119
Research works printed but not linked: 1
- [106]Bajaj JS, Kakiyama G, Savidge T, Takei H, Kassam ZA, Fagan A, Antibiotic-Associated Disruption of Microbiota Composition and Function in Cirrhosis Is Restored by Fecal Transplant. Hepatology 2018; 68: 1549– 1558. 29665102
- Authors
- Bajaj, J. S., Ng, S. C., & Schnabl, B.
- Affiliations
- Virginia Commonwealth University (US)
- Chinese University of Hong Kong (HK)
- University of California San Diego (US)
- Corresponding author
- Bajaj, Jasmohan S.
- Ng, Siew C.
- Schnabl, Bernd
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 76
- Issue
- 6
- Pages
- 1379-1391
- ISSN
- 0168-8278 (ISSN-L)
- PMC
- PMC9588437
- OpenAlex
- W4280549399
- Cited by
- 119
- References
- 124
- Citations by year
- 2026: 26 · 2025: 27 · 2024: 40 · 2023: 17 · 2022: 8 · 2020: 1
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Hepatology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- VA Biomedical Laboratory Research and Development (BX004594, CX001076)
- National Institutes of Health (R01 AA020703, U01 AA026939, R01 AA24726, BX004594, P30 DK120515, R21TR003095, P50 AA011999)
- Chinese University of Hong Kong
- Biocodex Microbiota Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- gut microbiota, liver disease, microbiota-based therapy, probiotics, fecal microbiota transplantation, engineered bacteria, postbiotics, bacteriophages, intestinal barrier dysfunction, precision medicine
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Bacteria, Humans, Liver Diseases, Probiotics, Microbiota, Dysbiosis
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