Cited by 191Smoking Behavior and CessationLiver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects

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Cigarette smoking and liver diseases

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Marti-Aguado, David, Clemente-Sanchez, Ana, Bataller, Ramon·2022·Journal of Hepatology

DOI 10.1016/j.jhep.2022.01.016

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Abstract

Cigarette smoking is a preventable risk factor for premature morbidity and mortality. A history of smoking is observed in approximately 40% of patients with liver disease, while a growing number of studies are investigating the potential impact of smoking in chronic liver diseases. This review discusses the effects of smoking on liver diseases, at multiple levels, with a focus on its potential causal role. Clinical evidence indicates that cigarette smoking negatively impacts the incidence and severity of fatty liver disease, fibrosis progression, hepatocellular carcinoma development, and the outcomes of patients with advanced liver disease. The underlying mechanisms are complex and involve different pathophysiological pathways including oxidative stress and oncogenic signals. Importantly, smoking promotes cardiovascular disease and extrahepatic cancers in patients with steatohepatitis and in transplant recipients. We discuss how promoting smoking cessation could improve the rates of treatment response (in clinical trials) and fibrosis regression, while reducing the risk of hepatocellular carcinoma and improving liver transplant outcomes. Finally, we discuss current challenges such as the referral of smokers to specialised units for smoking cessation.

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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026
Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes
Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
Forouzanfar, M. H., Afshin, A., Alexander, L. T., Anderson, H. R., Bhutta, Z. A., Biryukov, S., Brauer, M., Burnett, R., Cercy, K., Charlson, F. J., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31679-8 · Cited by 7,698
Liver fibrosis
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958
Self-citation
NAFLD: A multisystem disease
Byrne, C. D., & Targher, G. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.12.012 · Cited by 3,144
Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
Angulo, P., Kleiner, D. E., Dam-Larsen, S., Adams, L. A., Bjornsson, E. S., Charatcharoenwitthaya, P., Mills, P. R., Keach, J. C., Lafferty, H. D., Stahler, A., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.043 · Cited by 2,987
Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies
D'Amico, G., Garcia-Tsao, G., & Pagliaro, L. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2005.10.013 · Cited by 2,687
Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: a systematic analysis from the Global Burden of Disease Study 2015
Reitsma, M. B., Fullman, N., Ng, M., Salama, J. S., Abajobir, A., Abate, K. H., Abbafati, C., Abera, S. F., Abraham, B., Abyu, G. Y., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30819-x · Cited by 2,028
TLR4 enhances TGF-β signaling and hepatic fibrosis
Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942

Show all 147 references

Research works printed but not linked: 1

Waziry, 2017, The effects of waterpipe tobacco smoking on health outcomes: an updated systematic review and meta-analysis, Int J Epidemiol, 46, 32

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Kwok, T., Hui, R. W., Mao, X., Ling, G., Wong, D. K.-H., Huang, F., Fung, J., Seto, W., Yuen, M., & Mak, L. (2024) · Journal of Viral Hepatitis · doi:10.1111/jvh.14007 · Cited by 6
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Combined Effects of PFAS, Social, and Behavioral Factors on Liver Health
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Lifestyle and genetic risk of chronic liver disease in metabolically healthy and unhealthy individuals from the general population
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Authors: Marti-Aguado, D., Clemente-Sanchez, A., & Bataller, R.
Affiliations: University of Pittsburgh Medical Center (US)
Corresponding author: Bataller, Ramon
ORCID: Marti-Aguado, David
Clemente-Sanchez, Ana
Bataller, Ramon
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 2022-07
Volume: 77
Issue: 1
Pages: 191-205
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/j.jhep.2022.01.016
OpenAlex: W4210795703
Cited by: 190
References: 147
Citations by year: 2026: 33 · 2025: 67 · 2024: 60 · 2023: 24 · 2022: 6
FWCI: 5.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 349 d)
Locations: Journal of Hepatology (acceptedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (1U01AA026264-01, 1U01AA026972-01, 1U01AA026978-01, RO1AA018873)
National Institute of Diabetes and Digestive and Kidney Diseases (1R01DK117881-01)
Asociación Española para el Estudio del Hígado
Instituto de Salud Carlos III
Ministerio de Ciencia e Innovación
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: cigarette smoking, chronic liver disease, hepatic steatosis, liver fibrosis, hepatocellular carcinoma, steatohepatitis, oxidative stress, oncogenic signaling, smoking cessation, liver transplantation, cardiovascular disease, extrahepatic cancer, fibrosis regression
MeSH terms: Cigarette Smoking, Cardiovascular Diseases, Fibrosis, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Risk Factors, Smoking

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