Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo

Greuter, Thomas; Yaqoob, Usman; Gan, Can; Jalan-Sakrikar, Nidhi; Kostallari, Enis; Lu, Jianwen; Gao, Jinhang; Sun, Liankang; Liu, Mengfei; Sehrawat, Tejasav S.; Ibrahim, Samar H.; Furuta, Kunimaro; Nozickova, Katerina; Huang, Bing Q.; Gao, Bin; Simons, Michael; Cao, Sheng; Shah, Vijay H.

doi:10.1016/j.jhep.2022.03.029

Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo

Background & Aims: Liver sinusoidal endothelial cells (LSEC) are ideally situated to sense stiffness and generate angiocrine programs potentially regulating liver fibrosis, portal hypertension. We explored how specific focal adhesion (FA) proteins parlay LSEC mechanotransduction into stiffness-in…