Angiocrine signaling in sinusoidal homeostasis and liver diseases
Open accessAbstract
The hepatic sinusoids are composed of liver sinusoidal endothelial cells (LSECs), which are surrounded by hepatic stellate cells (HSCs) and contain liver-resident macrophages called Kupffer cells, and other patrolling immune cells. All these cells communicate with each other and with hepatocytes to maintain sinusoidal homeostasis and a spectrum of hepatic functions under healthy conditions. Sinusoidal homeostasis is disrupted by metabolites, toxins, viruses, and other pathological factors, leading to liver injury, chronic liver diseases, and cirrhosis. Alterations in hepatic sinusoids are linked to fibrosis progression and portal hypertension. LSECs are crucial regulators of cellular crosstalk within their microenvironment via angiocrine signaling. This review discusses the mechanisms by which angiocrine signaling orchestrates sinusoidal homeostasis, as well as the development of liver diseases. Here, we summarise the crosstalk between LSECs, HSCs, hepatocytes, cholangiocytes, and immune cells in health and disease and comment on potential novel therapeutic methods for treating liver diseases.
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Endothelial cells play a crucial role in homeostasis in the liver.
“Endothelial cells play a crucial role in homeostasis in the liver [285, 286].”
From Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells (2025) · cites this paper as [285]
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References 216 · Cited by 90
- Authors
- Gao, J., Lan, T., Kostallari, E., Guo, Y., Lai, E., Guillot, A., Ding, B., Tacke, F., Tang, C., & Shah, V. H.
- Affiliations
- Sichuan University (CN)
- Mayo Clinic (US)
- Stiftung Charité (DE)
- Corresponding author
- Tacke, Frank
- Tang, Chengwei
- Shah, Vijay H.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2024-09
- Volume
- 81
- Issue
- 3
- Pages
- 543-561
- ISSN
- 0168-8278 (ISSN-L)
- PMC
- PMC11906189
- OpenAlex
- W4397007836
- Cited by
- 90
- References
- 216
- Citations by year
- 2026: 44 · 2025: 40 · 2024: 6
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Hepatology (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- California Department of Fish and Game (Ta434/8-1, SFB/TRR 296, 403224013, SFB1382)
- Sichuan University (ZYYC23026, ZYGD18004)
- National Natural Science Foundation of China (82170623, 82241054, 82170625, 82322011)
- Gilead Sciences
- Deutsche Forschungsgemeinschaft
- NIH (R01 DK136511)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- angiocrine signaling, liver sinusoids, liver sinusoidal endothelial cells, hepatic stellate cells, Kupffer cells, liver disease, liver fibrosis, portal hypertension, cholangiocytes, immune cells, liver injury, liver cirrhosis, therapeutic target
- MeSH terms
- Animals, Cell Communication, Homeostasis, Humans, Kupffer Cells, Liver, Liver Diseases, Signal Transduction, Hepatocytes, Endothelial Cells, Hepatic Stellate Cells
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