The DOI matches its Crossref record; 7 of the 8 references it cites were found in a registry or an index.
Case report of eight pregnant women with syphilis
Open accessAbstract
Congenital syphilis may lead to severe sequelae in affected infants. The prevalence of syphilis in women of childbearing age has increased worldwide. From 2015 to 2018, we encountered eight pregnant women with syphilis including six with late latent and two with early latent syphilis. Seven pregnant women with syphilis received antibiotic therapies of oral amoxicillin, intravenous penicillin G, or the both. The syphilotherapies in four cases were considered effective, because rapid plasma reagin titers decreased. None of the seven pregnant women who received syphilotherapies had congenital syphilis. The remaining one woman who did not undergo a maternity checkup or syphilotherapy delivered a stillbirth with congenital syphilis at 29 gestational weeks.
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In the citing paper
“The incidence rose to 28% if diagnosed and treated in the second trimester, and reached 80% if diagnosed and treated in the third trimester.2,5,14”
From Fetal Outcome in Pregnancy Infected Syphilis Treated with Penicillin G: A Systematic Review: Analysis (2025) · cites this paper as [5]
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In the citing paper
“The incidence rose to 28% if diagnosed and treated in the second trimester, and reached 80% if diagnosed and treated in the third trimester.2,5,14”
From Fetal Outcome in Pregnancy Infected Syphilis Treated with Penicillin G: A Systematic Review: Analysis (2025) · cites this paper as [5]
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Citations
Cites
Increase in Incidence of Congenital Syphilis — United States, 2012–2014
Bowen, V. B., Su, J. R., Torrone, E., Kidd, S., & Weinstock, H. (2015) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6444a3 · Cited by 221
Update on syphilis and pregnancy
Tsimis, M. E., & Sheffield, J. S. (2017) · Birth Defects Research · doi:10.1002/bdra.23562 · Cited by 90
Epidemic syphilis: Maternal factors associated with congenital infection
McFarlin, B. L., Bottoms, S. F., Dock, B. S., & Isada, N. B. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(94)70223-3 · Cited by 70
Maternal Titers After Adequate Syphilotherapy During Pregnancy
Rac, M. W. F., Bryant, S. N., Cantey, J. B., McIntire, D. D., Wendel, G. D., & Sheffield, J. S. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu920 · Cited by 37
Sheffield, J. S., & Wendel, G. D. (1999) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-199903000-00015 · Cited by 20
Kanai, M., Arima, Y., Shimada, T., Hori, N., Yamagishi, T., Sunagawa, T., Tada, Y., Takahashi, T., Ohnishi, M., Matsui, T., et al. (2018) · Sexual Health · doi:10.1071/sh18033 · Cited by 16
Current status of syphilis in pregnant women in Japan
Suzuki, S., Sekizawa, A., Tanaka, M., Okai, T., Kinoshita, K., & Kitamura, T. (2016) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2016.1266477 · Cited by 14
Research works printed but not linked: 1
- Lukehart, 2012, Syphilis, vol. 9, 12
Cited by
Sorted by citations
Batteiger, T. A., Liu, E., Sheffield, J., Reno, H., Wangu, Z., Ghanem, K. G., & Tuddenham, S. (2024) · Sexually Transmitted Diseases · doi:10.1097/olq.0000000000002108 · Cited by 7
Fatiah, M. S., Tambing, Y., Bela, S. R. A., Afelya, T. I., Mollet, G. C. C., Florensia, W., Irjayanti, A., Irmanto, M., & Ilmidin (2026) · Clinical Epidemiology and Global Health · doi:10.1016/j.cegh.2025.102278 · Cited by 1
Expanding treatment options for syphilis during pregnancy: a review of alternatives to penicillin
Townsend, C. L., Mofenson, L., Gottlieb, S., Peters, R. P. H., Mitjà, J., Pérez‐Mañá, C., Abrams, E. J., Delany‐Moretlwe, S., Lockman, S., Waitt, C. J., et al. (2026) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2026.1879243 · Cited by 1
Nathaniel, J., & Simanjuntak, T. P. (2025) · Cermin Dunia Kedokteran · doi:10.55175/cdk.v52i1.1297
Novas perspectivas das manifestações clínicas da sífilis congênita
Silva, J. T. N., Freitas, C. B. L., Silva, M. F., Silva, D. R. G., & Pereira, L. M. D. O. (2024) · Revista Eletrônica Acervo Saúde · doi:10.25248/reas.e15137.2024
Metadata
- Authors
- Nakasuji, Y., Tanimura, K., Sasagawa, Y., Imafuku, H., Morizane, M., Fujioka, K., Ohji, G., & Yamada, H.
- Affiliations
- Kobe University (JP)
- Corresponding author
- Yamada, Hideto
- Venue
- Journal of Infection and Chemotherapy
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 26
- Issue
- 3
- Pages
- 298-300
- ISSN
- 1341-321X (ISSN-L)
- OpenAlex
- W2986600855
- Cited by
- 5
- References
- 8
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Infection and Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Kobe University Repository Kernel (Kobe University) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministry of Health, Labour and Welfare
- Topics
- Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
- Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Keywords
- maternal syphilis, congenital syphilis, latent syphilis, penicillin G, amoxicillin, syphilis treatment, stillbirth, RPR, women of reproductive age
- MeSH terms
- Adult, Anti-Bacterial Agents, Female, Humans, Infant, Infant, Newborn, Pregnancy, Pregnancy Complications, Infectious, Syphilis, Syphilis, Congenital, Young Adult
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