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Cited by 68Psoriasis: Treatment and PathogenesisHair Growth and DisordersDermatology and Skin Diseases

Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?

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Rittié, Laure, Tejasvi, Trilokraj, Harms, Paul W., Xing, Xianying, Nair, Rajan P., Gudjonsson, Johann E., Swindell, William R., Elder, James T.·2016·Journal of Investigative Dermatology
DOI 10.1016/j.jid.2016.05.113PMC PMC5112032
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Abstract

In a transcriptome study of lesional psoriatic skin (PP) versus normal skin, we found a coexpressed gene module (N5) enriched 11.5-fold for lipid biosynthetic genes. We also observed fewer visible hairs in PP skin, compared with uninvolved nonlesional psoriatic skin or normal skin (P < 0.0001). To ask whether these findings might be due to abnormalities of the pilosebaceous unit, we carried out three-dimensional morphometric analysis of paired PP and nonlesional psoriatic skin biopsies. Sebaceous glands were markedly atrophic in PP versus nonlesional psoriatic skin (91% average reduction in volume, P = 0.031). Module N5 genes were strongly downregulated in PP versus normal skin (fold change < 0.25, 44.4-fold) and strongly upregulated in sebaceous hyperplasia (fold change > 4, 54.1-fold). The intersection of PP-downregulated and sebaceous hyperplasia-upregulated gene lists generated a gene expression signature consisting solely of module N5 genes, whose expression in PP versus normal skin was inversely correlated with the signature of IL17-stimulated keratinocytes. Despite loss of visible hairs, morphometry identified elongated follicles in PP versus nonlesional psoriatic skin (average 1.7 vs. 1.2 μm, P = 0.020). These results document sebaceous gland atrophy in nonscalp psoriasis, identify a cytokine-regulated set of sebaceous gland signature genes, and suggest that loss of visible hair in PP skin may result from abnormal sebaceous gland function.

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  • An increase in the levels of phospholipids, triacylglycerols, and cholesterol was found in the epidermis of psoriatic patients, which correlated with the severity of psoriasis.

    “However, an increase in the levels of phospholipids, triacylglycerols, and cholesterol were found in the epidermis of psoriatic patients, which correlated with the severity of psoriasis.36–38”

    From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [37]

    The Results report no apparent difference in neutral-lipid staining of the stratum corneum between lesional and nonlesional skin. The Discussion likewise reports no obvious stratum-corneum staining difference and markedly reduced staining in sebaceous glands, rather than the claimed lipid increase. The paper does not report a correlation of epidermal lipid levels with psoriasis severity. (LLM, conf=0.78)

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Cited by

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Authors
Rittié, L., Tejasvi, T., Harms, P. W., Xing, X., Nair, R. P., Gudjonsson, J. E., Swindell, W. R., & Elder, J. T.
Affiliations
University of Michigan (US)
Corresponding author
Elder, James T.
ORCID
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2016-09
Volume
136
Issue
9
Pages
1792-1800
ISSN
0022-202X (ISSN-L)
DOI
10.1016/j.jid.2016.05.113
PMC
PMC5112032
OpenAlex
W2437920145
Cited by
68
References
1
Citations by year
2026: 4 · 2025: 3 · 2024: 17 · 2023: 13 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 6
FWCI
2.63
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Investigative Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Veterans Affairs
  • American Skin Association
  • University of Michigan (AR059678)
  • National Institutes of Health (AR062382, NIH-R01, AR060802, AR054966)
  • Medical School, University of Michigan
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR050511, R01AR042742, K01AR059678, R01AR065183, R01AR063611, K08AR060802, R01AR054966)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
psoriasis, sebaceous gland atrophy, pilosebaceous unit, sebaceous hyperplasia, lipid biosynthesis genes, IL-17, keratinocytes, transcriptome, 3D morphometry
MeSH terms
Adult, Alopecia, Atrophy, Biopsy, Needle, DNA-Binding Proteins, Female, Gene Expression Regulation, Humans, Immunohistochemistry, Male, Nuclear Proteins, Psoriasis, Sebaceous Glands, Sensitivity and Specificity, Cytokines, RNA-Binding Proteins, Disease Progression, Cell Cycle Proteins, Tissue Culture Techniques, Transcriptome

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