Challenges in developing a human model system for skin microbiome research
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The use of human skin explants is more suitable for hosting the complete microbiota, but systemic pre-surgical prophylaxis may affect the integrity of the native microbiome, a problem that can only be overcome by using skin explants from non-prophylaxed donors.
“Therefore, the use of human skin explants is certainly more suitable, but the systemic pre-surgical prophylaxis normally performed before surgical operations may affect the integrity of the native microbiome, a problem that can only be overcome by using skin explants deriving from non-prophylaxed donors [133].”
From Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account? (2024) · cites this paper as [133]
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Experimental — accuracy not yet measuredRodent skin has its own microbiota that differs from human skin microbial communities, and attempts to model human microbiota on animal skin are prevented by competition from the native flora, in addition to intrinsic morphological differences with human skin.
“Indeed, besides having intrinsic morphological differences with human skin, disadvantaging germ-free animal models, rodent skin is characterized by its own microbiota, which obviously differs from the microbial communities of human skin; thus, the attempts to model human microbiota on animal skin are prevented due to the competition exerted by the native flora [133,134].”
From Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account? (2024) · cites this paper as [133]
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Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806 · see citing works
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Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account?
Galvan, A., Pellicciari, C., & Calderan, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021165 · Cited by 11 · see citing works
- Authors
- Larson, P. J., Chong, D., Fleming, E., & Oh, J.
- Affiliations
- The Jackson Laboratory for Genomic Medicine (US)
- Corresponding author
- Oh, Julia
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 141
- Issue
- 1
- Pages
- 228-231.e4
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC7719096
- OpenAlex
- W3034149874
- Cited by
- 43
- References
- 1
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 15 · 2022: 3
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- U.S. Department of Defense
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- skin microbiome, human skin, model systems, host-microbe interactions, microbial communities, rodent models, skin health, skin diseases, cosmetic applications, therapeutic target
- MeSH terms
- Humans, Skin, Biomedical Research, Microbiota
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