First Structures of an Active Bacterial Tyrosinase Reveal Copper Plasticity

Sendovski, Mor; Kanteev, Margarita; Ben-Yosef, Vered Shuster; Adir, Noam; Fishman, Ayelet

doi:10.1016/j.jmb.2010.10.048

First Structures of an Active Bacterial Tyrosinase Reveal Copper Plasticity

Tyrosinase is a member of the type 3 copper enzyme family that is involved in the production of melanin in a wide range of organisms. The crystal structures of a tyrosinase from Bacillus megaterium were determined at a resolution of 2.0-2.3 Å. The enzyme crystallized as a dimer in the asymmetric …