The DOI matches its Crossref record; 189 of the 189 references it cites were found in a registry or an index.
Molecular Mechanisms of Two-Component Signal Transduction
Open accessAbstract
Two-component systems (TCS) comprising sensor histidine kinases and response regulator proteins are among the most important players in bacterial and archaeal signal transduction and also occur in reduced numbers in some eukaryotic organisms. Given their importance to cellular survival, virulence, and cellular development, these systems are among the most scrutinized bacterial proteins. In the recent years, a flurry of bioinformatics, genetic, biochemical, and structural studies have provided detailed insights into many molecular mechanisms that underlie the detection of signals and the generation of the appropriate response by TCS. Importantly, it has become clear that there is significant diversity in the mechanisms employed by individual systems. This review discusses the current knowledge on common themes and divergences from the paradigm of TCS signaling. An emphasis is on the information gained by a flurry of recent structural and bioinformatics studies.
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“Typically, lemA is part of a two-component regulatory system, which have been well-studied across bacterial systems92−94 (but that have not yet been observed in Mycoplasma to our knowledge), and are involved in regulation of various cellular processes varying from phosphate uptake, to respiration, to sporulation.”
From Toward the Complete Functional Characterization of a Minimal Bacterial Proteome (2022) · cites this paper as [92]
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“lemA-gacS/0604 | cell growth and morphology | two component sensor/membrane”
From Toward the Complete Functional Characterization of a Minimal Bacterial Proteome (2022) · cites this paper as [92]
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1 retracted
Ryan, R. P., Fouhy, Y., Lucey, J. F., Crossman, L. C., Spiro, S., He, Y., Zhang, L., Heeb, S., Cámara, M., Williams, P. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600345103 · Cited by 506
RetractedTwo-Component Signal Transduction
Stock, A., Robinson, V. L., & Goudreau, P. N. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.183 · Cited by 3,653
PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light
Taylor, B. L., & Zhulin, I. B. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.479-506.1999 · Cited by 1,632
Structural identification of a bacterial quorum-sensing signal containing boron
Chen, X., Schauder, S., Potier, N., DORSSELAER, A. V., Pelczer, I., Bassler, B. L., & Hughson, F. M. (2002) · Nature · doi:10.1038/415545a · Cited by 1,572
Identification of direct residue contacts in protein–protein interaction by message passing
Weigt, M., White, R. A., Szurmant, H., Hoch, J. A., & Hwa, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805923106 · Cited by 1,025
Self-citationBiological Insights from Structures of Two-Component Proteins
Gao, R., & Stock, A. (2009) · Annual Review of Microbiology · doi:10.1146/annurev.micro.091208.073214 · Cited by 793
Specificity in Two-Component Signal Transduction Pathways
Laub, M. T., & Goulian, M. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.042007.170548 · Cited by 752
Stimulus Perception in Bacterial Signal-Transducing Histidine Kinases
Mascher, T., Helmann, J. D., & Unden, G. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00020-06 · Cited by 723
Ovchinnikov, S., Kamisetty, H., & Baker, D. (2014) · eLife · doi:10.7554/elife.02030 · Cited by 629
Paul, R., Weiser, S., Amiot, N. C., Chan, C., Schirmer, T., Giese, B., & Jenal, U. (2004) · Genes & Development · doi:10.1101/gad.289504 · Cited by 612
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Chevalier, S., Bouffartigues, E., Bodilis, J., Maillot, O., Lesouhaitier, O., Feuilloley, M. G. J., Orange, N., Dufour, A., & Cornélis, P. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux020 · Cited by 456
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Vergalli, J., Bodrenko, I. V., Masi, M., Moynié, L., Acosta‐Gutiérrez, S., Naismith, J. H., Davin‐Regli, A., Ceccarelli, M., van den Berg, B., Winterhalter, M., et al. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0294-2 · Cited by 420
The Mechanisms of Disease Caused by Acinetobacter baumannii
Morris, F. C., Dexter, C., Kostoulias, X., Uddin, M. I., & Peleg, A. Y. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01601 · Cited by 362
Metadata
- Authors
- Zschiedrich, C. P., Keidel, V., & Szurmant, H.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Szurmant, Hendrik
- ORCID
- Szurmant, Hendrik
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 428
- Issue
- 19
- Pages
- 3752-3775
- ISSN
- 0022-2836 (ISSN-L)
- PMC
- PMC5023499
- OpenAlex
- W2498485322
- Cited by
- 540
- References
- 189
- Citations by year
- 2026: 33 · 2025: 54 · 2024: 64 · 2023: 54 · 2022: 63 · 2021: 63 · 2020: 58 · 2019: 69 · 2018: 40 · 2017: 39 · 2016: 2
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- US National Institute of General Medical Sciences, National Institutes of Health (GM106085)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- two-component systems, signal transduction, sensor histidine kinase, response regulator proteins, bacterial signaling, signal detection, protein structure, molecular mechanisms
- MeSH terms
- Histidine Kinase, Archaea, Bacteria, Gene Expression Regulation, Transcription Factors, Signal Transduction, Eukaryota
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