In silico evaluation of new mangiferin-based Positron Emission Tomography radiopharmaceuticals through the inhibition of metalloproteinase-9

Gálvez-Rodríguez, Andy; Ferino-Pérez, Anthuan; Rodríguez-Riera, Zalua; Guerra, Idania Rodeiro; Jáuregui-Haza, Ulises J.

doi:10.1016/j.jmgm.2023.108569

In silico evaluation of new mangiferin-based Positron Emission Tomography radiopharmaceuticals through the inhibition of metalloproteinase-9

Metalloproteinase-9 (MMP-9) is a key protein in cancer advancement and metastasis owing to its ability to degrade some extracellular matrix components. Mangiferin, a natural polyphenolic compound, has demonstrated through experimental and theoretical studies to be a great anticancer agent for the…