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Cited by 18Antimicrobial Resistance in StaphylococcusOtolaryngology and Infectious DiseasesDermatological diseases and infestations

Risk factors for and molecular characteristics of methicillin-resistant Staphylococcus aureus nasal colonization among healthy children in southern Taiwan, 2005–2010

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Chen, Chih-Ho, Kuo, Kuang-Che, Hwang, Kao-Pin, Lin, Tzou-Yien, Huang, Yhu-Chering·2019·Journal of Microbiology, Immunology and Infection
DOI 10.1016/j.jmii.2018.09.003
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Abstract

Background/purpose Nasal colonization of Staphylococcus aureus is a well-defined risk factor for subsequent infection. This study investigated the prevalence of methicillin-resistant S. aureus (MRSA) in southern Taiwan and aimed to identify the host factors for S. aureus colonization and the virulence factor of Panton-Valentine Leukocidin (PVL) genes. Methods In a hospital-based study in Kaohsiung from Oct. 2005 to Dec. 2010, we performed nasal swab in the healthy children aged 2–60 months. We examined the relationship between the demographic characteristics and S. aureus nasal colonization. MRSA isolates were further analyzed for antimicrobial susceptibility and molecular characteristics. Results Among 3020 healthy children, 840 (27.8%) children had S. aureus nasal colonization. Of 840 isolates, 246 (29.3%) isolates were MRSA. MRSA colonization was significantly associated with age 2–6 months, day care attendance, and influenza vaccination. Breastfeeding was a protective factor against MRSA colonization. Most MRSA isolates were susceptible to trimethoprim-sulfamethoxazole and doxycycline. Ninety-four percent of MRSA isolates carried either type IV staphylococcal cassette chromosome mec (SCC mec ) or SCC mec V T and 87% belonged to the local community strains, namely clonal complex 59/SCC mec IV or V T . MRSA isolates with PVL-negative was associated with children with passive smoking. Conclusions Between 2005 and 2010, 27.8% and 8.14% of healthy children in southern Taiwan had nasal carriage of S. aureus and MRSA, respectively. Most MRSA isolates were local community strains. Several demographic factors associated with nasal MRSA colonization were identified.

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Cited by

Sorted by citations

Authors
Chen, C.-H., Kuo, K.-C., Hwang, K.-P., Lin, T.-Y., & Huang, Y.-C.
Affiliations
  • Chang Gung Memorial Hospital (TW)
  • China Medical University (TW)
  • Chang Gung University (TW)
Corresponding author
Huang, Yhu-Chering
ORCID
Venue
Journal of Microbiology, Immunology and Infection
Publisher
Elsevier BV
Published
2019-12
Volume
52
Issue
6
Pages
929-936
ISSN
1684-1182 (ISSN-L)
DOI
10.1016/j.jmii.2018.09.003
OpenAlex
W2891740098
Cited by
18
References
1
Citations by year
2025: 3 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 1
FWCI
1.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Microbiology Immunology and Infection (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Chang Gung Memorial Hospital
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Health Sciences › Medicine › Infectious Diseases › Otolaryngology and Infectious Diseases
  • Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
Keywords
methicillin-resistant Staphylococcus aureus, nasal carriage, children, risk factors, Panton-Valentine leukocidin, staphylococcal cassette chromosome mec, community-acquired MRSA, passive smoking, breastfeeding, daycare attendance, influenza vaccination, antimicrobial susceptibility, southern Taiwan
MeSH terms
Anti-Bacterial Agents, Bacterial Proteins, Bacterial Toxins, Carrier State, Doxycycline, Exotoxins, Female, Humans, Infant, Leukocidins, Male, Microbial Sensitivity Tests, Nose, Prospective Studies, Risk Factors, Staphylococcal Infections, Taiwan, Virulence, Trimethoprim, Sulfamethoxazole Drug Combination, Prevalence, Methicillin-Resistant Staphylococcus aureus, Healthy Volunteers

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