Social isolation stress exacerbates autoimmune disease in MRL/lpr mice
Abstract
The potential physiological mechanisms explaining an influence of psychosocial stress on autoimmune diseases remain undetermined. Exposure of chronic social isolation stress to MRL/lpr mice significantly enhanced the degree of proteinuria after 20 weeks of age and reduced the survival rate. The serum anti-dsDNA IgG2a levels were increased significantly by stress at 19 weeks of age, which was simultaneously accompanied by inhibition of the serum corticosterone elevation. Furthermore, stress caused increased IFN-gamma production from anti-CD3-stimulated splenic mononuclear cells, whereas IL-4 and IL-10 production decreased. These results indicated that isolation stress exacerbated autoimmune disease in MRL/lpr mice, the possible mechanism for which might be related to stress-induced dysregulation of Th1/Th2 balance and inhibition of the blood corticosterone response to inflammatory stimuli.
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In controlled laboratory settings, social contact is linked to longer lifespan across many social species, including insects, rodents, and primates.
“Even in controlled laboratory environments (where external threats to survival are absent), the presence of social contact is associated with increased lifespan across a range of social species including honeybees, ants, Drosophila melanogaster22,23, mice24,25, and rats26–28, as well as in free-ranging groups of macaques29, and baboons30.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [24]
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References 47 · Cited by 48
- Authors
- Chida, Y., Sudo, N., & Kubo, C.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Chida, Yoichi
- ORCID
- Sudo, Nobuyuki
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 158
- Issue
- 1-2
- Pages
- 138-144
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W1987560179
- Cited by
- 48
- References
- 47
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2019: 4 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (15659160, 16390200)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- social isolation stress, psychosocial stress, autoimmune disease, MRL/lpr mice, proteinuria, corticosterone, interferon-gamma, IL-4, IL-10, Th1/Th2 balance, survival
- MeSH terms
- Analysis of Variance, Animals, Antibodies, Antinuclear, Autoantibodies, Autoimmune Diseases, Corticosterone, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Immunoglobulin Isotypes, Male, Proteinuria, Social Isolation, Stress, Psychological, Time Factors, Survival Rate, Cytokines, Disease Progression, Mice, Inbred MRL lpr, Mice
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