Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice

Irvine, K-A.; Blakemore, W.F.

doi:10.1016/j.jneuroim.2006.03.002

Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice

Axon loss is recognised as a significant contributor to the progression of the disability associated with multiple sclerosis. Although evidence of axon damage is found in areas of chronic demyelination it is more frequently seen in association with acute demyelination. This study compares the inc…