MBP-PLP fusion protein-induced EAE in C57BL/6 mice

Kuerten, Stefanie; Lichtenegger, Felix S.; Faas, Susan; Angelov, Doychin N.; Tary-Lehmann, Magdalena; Lehmann, Paul V.

doi:10.1016/j.jneuroim.2006.03.021

MBP-PLP fusion protein-induced EAE in C57BL/6 mice

Gene knock-out and knock-in mice are becoming increasingly indispensable for mechanism-oriented studies of EAE. Most gene-modified mice are on the C57BL/6 background, for which presently there are only two EAE models available, the MOG peptide 35-55 and the PLP 178-191 peptide induced disease. Ho…