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Cited by 43Muscle Physiology and DisordersCytokine Signaling Pathways and InteractionsExercise and Physiological Responses

Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFα-induced resistance to IGF-I in myoblasts

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Strle, Klemen, McCusker, Robert H., Tran, Lynn, King, Alexandra, Johnson, Rodney W., Freund, Gregory G., Dantzer, Robert, Kelley, Keith W.·2007·Journal of Neuroimmunology
DOI 10.1016/j.jneuroim.2007.05.003PMC PMC2078530
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Abstract

IL-10 is an anti-inflammatory cytokine that suppresses synthesis of proinflammatory cytokines and their receptors. Here we tested the possibility that TNFalpha-induced hormone resistance in myoblasts might be overcome by IL-10. We found that IL-10 restores myogenesis by suppressing the ability of exogenous TNFalpha to inhibit IGF-I-induced myogenin. This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFalpha-induced IL-6 synthesis or ERK1/2 phosphorylation. Instead, IL-10 acts to prevent TNFalpha-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFalpha-induced resistance to IGF-I.

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Cited by

Sorted by citations

Authors
Strle, K., McCusker, R. H., Tran, L., King, A., Johnson, R. W., Freund, G. G., Dantzer, R., & Kelley, K. W.
Affiliations
University of Illinois Urbana-Champaign (US)
Corresponding author
Kelley, Keith W.
ORCID
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2007-08
Volume
188
Issue
1-2
Pages
48-55
ISSN
0165-5728 (ISSN-L)
DOI
10.1016/j.jneuroim.2007.05.003
PMC
PMC2078530
OpenAlex
W2088238416
Cited by
43
References
2
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 6
FWCI
0.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (AG 16710, R01AG023580, R01AG016710, AG 023580)
  • National Institute of Mental Health (MH071349, R01MH071349, R01MH051569, MH51569)
  • National Institute of Allergy and Infectious Diseases (R01AI050442, AI50442)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064862, DK 064862)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
IL-10, TNF-α, IGF-I resistance, myoblasts, myogenesis, myogenin, JNK phosphorylation, muscle progenitors, cytokine signaling, ERK1/2, interleukin-6
MeSH terms
Analysis of Variance, Animals, Cell Line, Dose-Response Relationship, Drug, Drug Interactions, Enzyme-Linked Immunosorbent Assay, Gene Expression Regulation, Immunologic Factors, Insulin-Like Growth Factor I, Interleukin-6, Interleukin-10, Interferon-alpha, Myogenin, Mitogen-Activated Protein Kinases, Myoblasts, Mice

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