Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells
Open accessAbstract
We recently showed that subretinal CX3CR1-dependent microglial cell (MC) accumulation may lead to age-related macular degeneration. The fate of MC after engulfing retinal debris is poorly understood. Severe photoreceptor degeneration was observed 40days after exposure to bright light in CX3CR1-deficient but not control mice, and more MCs accumulated in the subretinal space of the former than the latter. To study the fate of subretinal MCs in CX3CR1 competent animals, we used a dystrophic rat model in which abundant subretinal MC accumulation is observed secondary to retinal degeneration. In dystrophic rats, MCs containing rhodopsin or rod outer segment (ROS) debris were found outside the outer retina at sites suggesting choroidal and ciliary egress. In conclusion, our data indicate that MC accumulation at injury sites is independent of CX3CR1 and precedes photoreceptor degeneration. The ectopic presence of rhodopsin-positive MCs suggests that CX3CR1 participates in MC egress from the outer retina.
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Cx3cr1 knockout mice exhibited age-dependent subretinal microglial accumulation and retinal degeneration.
“Cx3cr1 knockout mice exhibited age-dependent subretinal microglial accumulation and retinal degeneration.37,38”
From CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models (2010) · cites this paper as [38]
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References 15 · Cited by 60
- Authors
- Raoul, W., Keller, N., Rodéro, M., Behar-Cohen, F., Sennlaub, F., & Combadière, C.
- Affiliations
- Inserm (FR)
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 198
- Issue
- 1-2
- Pages
- 56-61
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2060710997
- Cited by
- 60
- References
- 15
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 5
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- green
- inserm.hal.science
- Licence
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- CX3CR1, retinal microglia, phagocytosis, photoreceptor degeneration, rhodopsin, choroid, ciliary body, age-related macular degeneration, bright light exposure
- MeSH terms
- CX3C Chemokine Receptor 1, Animals, Cell Movement, Gene Expression Regulation, Light, Mice, Inbred C57BL, Mice, Transgenic, Phagocytes, Phagocytosis, Photoreceptor Cells, Retina, Retinal Degeneration, Rhodopsin, Time Factors, Microglia, Statistics, Nonparametric, Receptors, Chemokine, Microscopy, Electron, Transmission, Green Fluorescent Proteins, Mice
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