PBMCs protein expression profile in relapsing IFN-treated multiple sclerosis: A pilot study on relation to clinical findings and brain atrophy
Abstract
This cross-sectional study investigated with two-dimensional gel electrophoresis coupled to MALDI-TOF and MRI the relationship between PBMCs protein expression profile and whole-brain atrophy in 16 unselected RR-MS IFN-treated patients compared with 6 RR IFN-untreated and 12 matched healthy control subjects. Grey/white matter fraction, T1/T2 lesion load and clinical variables were considered too. Twenty six proteins showed significant differential expression among RR IFN-treated patients and control samples. Four of these (IN35, GANAB, PP1B, SEPT2) resulted correlated with clinical and MRI findings in RR IFN-treated MS patients. Future clinical applications remain to be validated by other techniques and confirmed by a larger study.
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GANAB is a differentially expressed protein from PBMCs in naive MS patients compared to RRMS patients undergoing IFN therapy.
“In 2009, De Masi and coworkers first evidenced GANAB as a differentially expressed protein from PBMCs in naive patients compared to the RRMS ones undergoing IFN therapy [447].”
From GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review (2022) · cites this paper as [447]
GANAB expression correlates with lesion load and disease duration in MS patients.
“a good correlation between GANAB, lesion load (LL) and disease duration (DD)”
From GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review (2022) · cites this paper as [447]
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References 56 · Cited by 26
- Authors
- De Masi, R., Vergara, D., Pasca, S., Acierno, R., Greco, M., Spagnolo, L., Blasi, E., Sanapo, F., Trianni, G., & Maffia, M.
- Affiliations
- University of Salento (IT)
- Ospedale Vito Fazzi (IT)
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 210
- Issue
- 1-2
- Pages
- 80-86
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2058468769
- Cited by
- 26
- References
- 56
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- AIRUS (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- relapsing-remitting multiple sclerosis, interferon beta therapy, peripheral blood mononuclear cells, protein expression patterns, brain atrophy, GANAB, SEPT2, biomarkers
- MeSH terms
- Adult, Aged, Atrophy, Brain, Cross-Sectional Studies, Female, Humans, Leukocytes, Mononuclear, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, Phosphoric Monoester Hydrolases, Pilot Projects, Predictive Value of Tests, Electrophoresis, Gel, Two-Dimensional, Disease Progression, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Multiple Sclerosis, Relapsing-Remitting, Proteomics, Young Adult
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