The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner
Open accessAbstract
Fumarate-containing pharmaceuticals are potent therapeutic agents that influence multiple cellular pathways. Despite proven clinical efficacy, there is a significant lack of data that directly defines the molecular mechanisms of action of related, yet distinct fumarate compounds. We systematically compared the impact of dimethyl fumarate (DMF), monomethyl fumarate (MMF) and a mixture of monoethyl fumarate salts (Ca(++), Mg(++), Zn(++); MEF) on defined cellular responses. We demonstrate that DMF inhibited NF-κB-driven cytokine production and nuclear translocation of p65 and p52 in an Nrf2-independent manner. Equivalent doses of MMF and MEF did not affect NF-κB signaling. These results highlight a key difference in the biological impact of related, yet distinct fumarate compounds.
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Linker, R. A., Lee, D.-H., Ryan, S., van Dam, A. M., Conrad, R., Bista, P., Zeng, W., Hronowsky, X., Buko, A., Chollate, S., et al. (2011) · Brain · doi:10.1093/brain/awq386 · Cited by 1,155
Self-citationKEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ
Lee, D.-F., Kuo, H.-P., Liu, M., Chou, C.-K., Xia, W., Du, Y., Shen, J., Chen, C.-T., Huo, L., Hsu, M.-C., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.07.025 · Cited by 399 · cited 5×
“DMF has been shown to inhibit NF-κB-mediated cellular responses (Gerdes et al., 2007; Ghoreschi et al., 2011; Kim et al., 2010; Lee et al., 2009; Loewe et al., 2001, 2002; Lv et al., 2013; Peng et al., 2012; Vandermeeren et al., 2001).”
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Metadata
- Authors
- Gillard, G. O., Collette, B., Anderson, J., Chao, J., Scannevin, R. H., Huss, D. J., & Fontenot, J. D.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 283
- Pages
- 74-85
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2068690343
- Cited by
- 173
- References
- 2
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gillard, G. O., Collette, B., Anderson, J., Chao, J., Scannevin, R. H., Huss, D. J., & Fontenot, J. D. (2015). DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner. Journal of Neuroimmunology. https://doi.org/10.1016/j.jneuroim.2015.04.006
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