MAIT cell subtypes in multiple sclerosis
Abstract
In patients with multiple sclerosis (MS) and healthy controls (HC) we studied circulating MAIT cells and MAIT cell subtypes expressing CXCR3 and CCR6 by flow cytometry. Absolute numbers of MAIT cells and specifically Tc17-like MAIT cells were lower in patients with primary progressive MS (PPMS) than in controls. Low numbers of Tc17-like MAIT cells were associated with smoking and high concentrations of myelin basic protein in the cerebrospinal fluid. Treatment with alemtuzumab and dimethyl fumarate decreased MAIT cell frequencies. Altogether, we have identified specific MAIT cell subtypes related to PPMS, smoking and demyelination, and MAIT cell effects of MS therapies.
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The MR1/MAIT cell axis has been associated with a number of inflammatory disorders, including those in the CNS.
“The MR1/MAIT cell axis has been associated with a number of inflammatory disorders, including those in the CNS [11, 12].”
From Control of the temporal development of Alzheimer’s disease pathology by the MR1/MAIT cell axis (2023) · cites this paper as [12]
Cites
Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206 · see citing works
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The immunology of multiple sclerosis
Attfield, K. E., Jensen, L. T., Kaufmann, M., Friese, M. A., & Fugger, L. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-022-00718-z · Cited by 380 · see citing works
Control of the temporal development of Alzheimer’s disease pathology by the MR1/MAIT cell axis
Wyatt-Johnson, S. K., Kersey, H. N., Codocedo, J. F., Newell, K. L., Landreth, G. E., Lamb, B. T., Oblak, A. L., & Brutkiewicz, R. R. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02761-6 · Cited by 22 · see citing works
- Authors
- Ammitzbøll, C., von Essen, M. R., Chow, H. H., McWilliam, O., Holm Hansen, R., & Sellebjerg, F.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Ammitzbøll, Cecilie
- Chow, Helene Højsgaard
- McWilliam, Oskar
- Sellebjerg, Finn
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 339
- Pages
- 577117
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2990136182
- Cited by
- 14
- References
- 1
- Citations by year
- 2024: 2 · 2023: 5 · 2022: 4 · 2021: 3
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Funders
- Danish Multiple Sclerosis Society
- Foundation for Research in Neurology
- Johnsen Foundation
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- mucosal-associated invariant T cells, multiple sclerosis, primary progressive multiple sclerosis, CXCR3, CCR6, smoking, myelin basic protein, cerebrospinal fluid, demyelination, alemtuzumab, dimethyl fumarate, peripheral blood T cells
- MeSH terms
- Mucosal-Associated Invariant T Cells, Adult, Female, Humans, Immunosuppressive Agents, Male, Middle Aged, Multiple Sclerosis, Smoking, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting
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