Enrichment of liver MAIT cells in a mouse model of Alzheimer's disease
Open accessAbstract
Emerging evidence has supported a role for the immune system and liver in Alzheimer's disease (AD). However, our understanding of how hepatic immune cells are altered in AD is limited. We previously found that brain mucosal-associated invariant T (MAIT) cell numbers are increased in AD. Furthermore, loss of MAIT cells and their antigen-presenting molecule, MR1, reduced amyloid-β accumulation in the brain. MAIT cells are also significantly present in the liver. Therefore, we sought to analyze MAIT and other immune cells in the AD liver. Increased frequency of activated MAIT cells (but not conventional T cells) were found in 8-month-old 5XFAD mouse livers. Therefore, these data raise the possibility that there is a role for peripheral MAIT cells in AD pathology.
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The MR1/MAIT cell axis substantially contributes to AD neuropathology.
“We have recently reported that an immune axis consisting of the major histocompatibility complex class I‐like molecule MR1 and mucosal‐associated invariant T (MAIT) cells substantially contribute to the neuropathology of AD. 7 , 8”
From The MR1/MAIT cell axis enhances dystrophic neurite development in Alzheimer's disease (2025) · cites this paper as [8]
The Introduction (page unavailable) reports that loss of MAIT cells delayed amyloid-β accumulation in 5XFAD mice, supporting a role for this axis in a mouse model of AD pathology. The paper does not establish that the axis substantially contributes to AD neuropathology generally; its liver findings concern MAIT-cell abundance and activation, not a causal effect on neuropathology. (LLM, conf=0.85)
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Control of the temporal development of Alzheimer’s disease pathology by the MR1/MAIT cell axis
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Cited by
Sorted by citations
The MR1/MAIT cell axis enhances dystrophic neurite development in Alzheimer's disease
Wyatt‐Johnson, S. K., Ackley, S., Warren, J., Priya, R., Wan, J., Liu, S., & Brutkiewicz, R. R. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.14480 · Cited by 4 · see citing works
“7,8 MAIT cells are an innate-like T cell subpopulation that has been found to contribute to inflammatory conditions, both in the central nervous system and periphery.”
Self-citation
- Authors
- Wyatt-Johnson, S. K., Kersey, H. N., & Brutkiewicz, R. R.
- Affiliations
- Indiana University Indianapolis (US)
- Corresponding author
- Brutkiewicz, Randy R.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2024-05
- Volume
- 390
- Pages
- 578332
- ISSN
- 0165-5728 (ISSN-L)
- PMC
- PMC11382344
- OpenAlex
- W4393029452
- Cited by
- 7
- References
- 4
- Citations by year
- 2026: 2 · 2025: 5
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 329 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Journal of Neuroimmunology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- National Cancer Institute (P30 CA082709)
- National Center for Advancing Translational Sciences (T32-AI-060519)
- National Institutes of Health (R21 AG071269-01)
- National Institute of Diabetes and Digestive and Kidney Diseases (U54 DK106846, 1S10D012270)
- Indiana University
- National Institute of Allergy and Infectious Diseases
- Alzheimer's Association (AARGD-NTF-22-928,436)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- Alzheimer's disease, mucosal-associated invariant T cells, liver, 5xFAD mice, amyloid-beta deposition, peripheral immune cells, neuroinflammation
- MeSH terms
- Mucosal-Associated Invariant T Cells, Alzheimer Disease, Animals, Disease Models, Animal, Female, Humans, Liver, Male, Mice, Inbred C57BL, Mice, Transgenic, Mice
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