The importance of non-motor disturbances to quality of life in Parkinson's disease
Abstract
The term health-related quality of life (HRQoL) refers to the consequences of the disease and treatment on the patients' life, as perceived and evaluated by patients themselves. Parkinson's disease is a complex disorder characterized by motor manifestations and an impressive diversity of non-motor symptoms (NMS) that may be simultaneously present in the same patient. Some of these non-motor symptoms (for example, depression, fatigue, or pain) have got evidence enough to be considered determinant factors of HRQoL. For others, evidence is incomplete or results of the studies are inconsistent. The availability of instruments for assessment of a wide set of NMS allows to evaluate the impact of NMS, as a whole and compared to the motor disorder, on the HRQoL. In that scenario, the whole NMS showed a close association with the quality of life deterioration, exceeding even the effects of the motor disorder.
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Gastrointestinal dysfunction is one of the most common non-motor symptoms in Parkinson's disease, with a prevalence of 70-80%.
“One of the most common non-motor symptoms in PD are GI dysfunction, with a prevalence of 70-80% (Martinez-Martin, 2011).”
From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as Martinez-Martin, 2011
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References 90 · Cited by 160
- Authors
- Martinez-Martin, P.
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 310
- Issue
- 1-2
- Pages
- 12-16
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2051517155
- Cited by
- 160
- References
- 90
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 5 · 2022: 8 · 2021: 14 · 2020: 14 · 2019: 7 · 2018: 21 · 2017: 15 · 2016: 12 · 2015: 19 · 2014: 5 · 2013: 12 · 2012: 8
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, non-motor symptoms, health-related quality of life, depression, fatigue, pain, motor symptoms, quality of life instruments
- MeSH terms
- Anxiety, Cognition Disorders, Depression, Fatigue, Humans, Pain, Parkinson Disease, Quality of Life, Sleep Wake Disorders
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