Genetic variation in angiotensin converting-enzyme affects the white matter integrity and cognitive function of amnestic mild cognitive impairment patients

Li, Yanzhi; Zhang, Zhengsheng; Deng, Linglong; Bai, Feng; Shi, Yongmei; Yu, Hui; Xie, Chunming; Yuan, Yonggui; Zhang, Zhijun

doi:10.1016/j.jns.2017.06.026

Genetic variation in angiotensin converting-enzyme affects the white matter integrity and cognitive function of amnestic mild cognitive impairment patients

Angiotensin-converting enzyme (ACE) gene has been implicated in amnestic mild cognitive impairment (aMCI). Most human genetic studies have focused on ACE insertion (I)/deletion (D) polymorphism and yielded conflicting results. In this work, we evaluated the relationships between cognitive functio…