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Cited by 18Intracerebral and Subarachnoid Hemorrhage ResearchDementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

The role of cerebral microbleeds in the incidence of post-stroke dementia

Yatawara, Chathuri, Guevarra, Anne Cristine, Ng, Kok Pin, Chander, Russell, Lam, Bonnie Yin Ka, Wong, Adrian, Mok, Vincent, Kandiah, Nagaendran·2020·Journal of the Neurological Sciences
DOI 10.1016/j.jns.2020.116736
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Abstract

Microbleeds are a marker of cerebrovascular disease however its role in incident post-stroke dementia (PSD) remains unclear. We investigated whether microbleeds are associated with incident PSD, domain-specific cognitive impairment and cognitive decline over a 2-year follow-up; and whether microbleeds interact with acute stroke-related infarcts to synergistically affect cognitive outcomes. In a cohort of patients with first-episode mild ischemic stroke and no pre-stroke dementia, we found patients with 3 or more mixed microbleeds (presence of both lobar and deep) were 4 times more at risk of developing PSD compared to patients with no microbleeds. Patients with strictly lobar microbleeds were 10 times more at risk of developing memory impairment while patients with possible CAA-related microbleeds were 8 times more at risk of developing memory impairment compared to patients with no microbleeds. Microbleeds did not predict cognitive decline at the 2-year follow-up. Acute stroke infarcts were not related to any cognitive outcomes. Microbleeds did not interact with stroke infracts to synergistically affect cognitive outcomes. Our findings suggest that the combined effect of possible CAA and hypertension-related microbleeds play a large and direct role in incident PSD. Management of vasculopathy and amyloid deposition may positively impact cognitive outcomes after stroke.

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  • In patients with first episode ischaemic stroke, three or more microbleeds were associated with higher risk of developing vascular dementia.

    “Meanwhile in patients with first episode ischaemic stroke, three or more microbleeds were associated with higher risk of developing vascular dementia [39].”

    From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [39]

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Metadata

Authors
Yatawara, C., Guevarra, A. C., Ng, K. P., Chander, R., Lam, B. Y. K., Wong, A., Mok, V., & Kandiah, N.
Affiliations
  • National Neuroscience Institute (SG)
  • UNSW Sydney (AU)
  • Chinese University of Hong Kong (HK)
  • SingHealth (SG)
Corresponding author
Kandiah, Nagaendran
ORCID
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
2020-05
Volume
412
Pages
116736
ISSN
0022-510X (ISSN-L)
DOI
10.1016/j.jns.2020.116736
OpenAlex
W3006406288
Cited by
18
References
2
Citations by year
2026: 2 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • A*STAR Biomedical Research Council (BMRC 04/1/36/372)
  • Health Services Research Fund (0708041)
  • Food and Health Bureau
Topics
  • Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
cerebral microbleeds, post-stroke dementia, minor stroke, cognitive impairment, memory impairment, cognitive decline, cerebral amyloid angiopathy, lobar microbleeds, hypertension, cerebrovascular disease, amyloid deposition
MeSH terms
Cerebral Hemorrhage, Dementia, Humans, Magnetic Resonance Imaging, Incidence, Cerebral Amyloid Angiopathy, Stroke

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