Neuro-immune deconvolution analysis of OAS3 as a transcriptomic central node in HIV-associated neurocognitive disorders

Sanfilippo, Cristina; Castrogiovanni, Paola; Vinciguerra, Manlio; Imbesi, Rosa; Ulivieri, Martina; Fazio, Francesco; Cantarella, Antonio; Nunnari, Giuseppe; Di Rosa, Michelino

doi:10.1016/j.jns.2023.120562

Neuro-immune deconvolution analysis of OAS3 as a transcriptomic central node in HIV-associated neurocognitive disorders

Neurological complications of AIDS (NeuroAIDS) include primary HIV-associated neurocognitive disorder (HAND). OAS3 is an enzyme belonging to the 2', 5' oligoadenylate synthase family induced by type I interferons and involved in the degradation of both viral and endogenous RNA. Here, we used micr…