The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats
Abstract
We examined the angiotensin I-converting enzyme (ACE) inhibitory activity and antihypertensive effect of the hot water extract of wakame, Undaria pinnatifida. Ten dipeptides were isolated from the extract by several steps of chromatography, and their amino acid sequences were Tyr-His, Lys-Trp, Lys-Tyr, Lys-Phe, Phe-Tyr, Val-Trp, Val-Phe, Ile-Tyr, Ile-Trp, and Val-Tyr. Both single administration and repeated oral administration of synthetic Tyr-His, Lys-Tyr, Phe-Tyr, and Ile-Tyr significantly decreased blood pressure in spontaneously hypertensive rats.
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“Among seaweed-derived peptides, species such as Undaria pinnatifida (Phaeophyceae), Neopyropia yezoensis (formerly Porphyra yezoensis) (Rhodophyta), Ulva rigida, and Ulva clathrata (formerly Enteromorpha clathrata) have shown ACE inhibitory activity [53–57].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [53]
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Cites
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A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects
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Cheung, H. S., & Cushman, D. W. (1973) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(73)90352-5 · Cited by 271
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Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida)
Suetsuna, K., & Nakano, T. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00110-8 · Cited by 243
Self-citationSuetsuna, K., & Chen, J. (2001) · Marine Biotechnology · doi:10.1007/s10126-001-0012-7 · Cited by 219
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1 of the 32 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Nakano, 1998, Hypotensive effects of wakame, J Jpn Soc Clin Nutr, 20, 92
- Nara, 1998, Medical treatment of risk factor-dietary treatment, Jpn Circ J, 61, 66
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Holdt, S. L., & Kraan, S. (2011) · Journal of Applied Phycology · doi:10.1007/s10811-010-9632-5 · Cited by 2,135
Algal Proteins: Extraction, Application, and Challenges Concerning Production
Bleakley, S., & Hayes, M. (2017) · Foods · doi:10.3390/foods6050033 · Cited by 1,092
Wu, J., Aluko, R. E., & Nakai, S. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051263l · Cited by 562
Je, J., Qian, Z., Byun, H., & Kim, S. (2007) · Process Biochemistry · doi:10.1016/j.procbio.2007.02.006 · Cited by 490
Rajapakse, N., Mendis, E., Byun, H., & Kim, S. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.02.005 · Cited by 467
Metadata
- Authors
- Suetsuna, K., Maekawa, K., & Chen, J.-R.
- Affiliations
- National Fisheries University (JP)
- Taipei Medical University (TW)
- Corresponding author
- Chen, Jiun-Rong
- ORCID
- Chen, Jiun-Rong
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 15
- Issue
- 5
- Pages
- 267-272
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W2002247285
- Cited by
- 249
- References
- 32
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 11 · 2023: 15 · 2022: 14 · 2021: 16 · 2020: 13 · 2019: 17 · 2018: 13 · 2017: 15 · 2016: 7 · 2015: 10 · 2014: 17 · 2013: 20 · 2012: 11
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- Undaria pinnatifida, dipeptides, antihypertensive effect, angiotensin-converting enzyme inhibition, blood pressure, spontaneously hypertensive rats, hot water extract
- MeSH terms
- Amino Acid Sequence, Angiotensin-Converting Enzyme Inhibitors, Animals, Antihypertensive Agents, Blood Pressure, Dipeptides, Hypertension, Kinetics, Plant Extracts, Rats, Inbred SHR, Undaria, Rats
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