Cited by 162Diet, Metabolism, and DiseaseLiver Disease Diagnosis and TreatmentGut microbiota and health

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Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease

Spruss, Astrid, Bergheim, Ina·2009·The Journal of Nutritional Biochemistry

DOI 10.1016/j.jnutbio.2009.05.006

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Abstract

Worldwide, not only the prevalence of obesity has increased dramatically throughout the last three decades but also the incidences of co-morbid conditions such as diabetes type 2 and liver disease have increased. The 'hepatic manifestation of the metabolic syndrome' is called nonalcoholic fatty liver disease (NAFLD) and comprises a wide spectrum of stages of liver disease ranging from simple steatosis to liver cirrhosis. NAFLD of different stages is found in approximately 30% of adults and approximately 20% in the US population. Not just a general overnutrition but also an elevated intake of certain macronutrients such as fat and carbohydrates and herein particularly fructose has been claimed to be risk factors for the development for NAFLD; however, the etiology of this disease is still unknown. The present review outlines some of the potential mechanisms associated with the development of NAFLD and fructose intake with a particular focus on the role of the intestinal barrier functions.

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Authors: Spruss, A., & Bergheim, I.
Affiliations: University of Hohenheim (DE)
Corresponding author: Bergheim, Ina
ORCID: Bergheim, Ina
Venue: The Journal of Nutritional Biochemistry
Publisher: Elsevier BV
Published: 2009-09
Volume: 20
Issue: 9
Pages: 657-662
ISSN: 0955-2863 (ISSN-L)
DOI: 10.1016/j.jnutbio.2009.05.006
OpenAlex: W2088617983
Cited by: 162
References: 57
Citations by year: 2026: 5 · 2025: 2 · 2024: 2 · 2023: 10 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 20 · 2018: 14 · 2017: 11 · 2016: 8 · 2015: 11 · 2014: 14 · 2013: 11 · 2012: 12
FWCI: 1.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Nutritional Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (BE2376/4-1)
Bundesministerium für Bildung und Forschung (0315084)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: non-alcoholic fatty liver disease, dietary fructose, intestinal barrier, metabolic syndrome, hepatic steatosis, liver cirrhosis, obesity, type 2 diabetes, fructose consumption, pathogenesis
MeSH terms: Animals, Dietary Carbohydrates, Fatty Liver, Fructose, Glucose, Humans, Intestinal Mucosa, Liver, Risk Factors, Transcription, Genetic, Dietary Sucrose

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Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease

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