Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis
Kraus, V.B., Burnett, B., Coindreau, J., Cottrell, S., Eyre, D., Gendreau, M., Gardiner, J., Garnero, P., Hardin, J., Henrotin, Y., Heinegård, D., Ko, A., Lohmander, L.S., Matthews, G., Menetski, J., Moskowitz, R., Persiani, S., Poole, A.R., Rousseau, J.-C., Todman, M.·2011·Osteoarthritis and Cartilage
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Items 101–200 of 328
- The current state of the osteoarthritis drug development pipeline: a comprehensive narrative review of the present challenges and future opportunitiesH. Kim, Jinwon Seo, Yun-Ha Lee, Kiwon Park, T. A. Perry, N. Arden, A. Mobasheri, Heonsik Choi · 2022 · Therapeutic Advances in Musculoskeletal Disease
- Discovery of circulating proteins associated to knee radiographic osteoarthritisL. Lourido, B. Ayoglu, J. Fernández-Tajes, N. Oreiro, F. Henjes, C. Hellström, J. Schwenk, C. Ruiz-Romero, P. Nilsson, F. Blanco · 2017 · Scientific Reports
- Systemic biochemical markers of joint metabolism and inflammation in relation to radiographic parameters and pain of the knee: data from CHECK, a cohort of early-osteoarthritis subjectsW.E. van Spil, S.C. Nair, Margot B. Kinds, Pieter J. Emans, W.K. Hilberdink, Paco M J Welsing, Floris P. J. G. Lafeber · 2014 · Osteoarthritis and Cartilage
- Synovial fluid levels of bradykinin correlate with biochemical markers for cartilage degradation and inflammation in knee osteoarthritisFrancesca Bellucci, Stefania Meini, Paola Cucchi, Claudio Catalani, Andrea Nizzardo, Alberto Riva, Giacomo Maria Guidelli, Paolo Ferrata, Antonella Fioravanti, Carlo Alberto Maggi · 2013 · Osteoarthritis and Cartilage
- The evolving role of biomarkers for osteoarthritisMuneaki Ishijima, Haruka Kaneko, Kazuo Kaneko · 2014 · Therapeutic Advances in Musculoskeletal Disease
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- Biomarkers and personalised medicine in rheumatoid arthritis: a proposal for interactions between academia, industry and regulatory bodiesPierre Miossec, C L Verweij, Lars Klareskog, Costantino Pitzalis, Anne C Barton, Frits J.F. Lekkerkerker, Susanne Reiter, Andrea Laslop, Ferdinand C Breedveld, E Abadie et al. · 2011 · Annals of the Rheumatic Diseases
- Effect of antiresorptive and anabolic bone therapy on development of osteoarthritis in a posttraumatic rat model of OACedo M. Bagi, Edwin R. Berryman, David E. Zakur, Dean P. Wilkie, Catharine J. Andresen · 2015 · Arthritis Research & Therapy
- Fractalkine (CX3CL1): A Biomarker Reflecting Symptomatic Severity in Patients with Knee OsteoarthritisLi Wei Huo, Yong Liang Ye, Guang Wei Wang, Yong Guang Ye · 2015 · Journal of Investigative Medicine
- Association between cartilage and bone biomarkers and incidence of radiographic knee osteoarthritis (RKOA) in UK females: a prospective studyOrit Blumenfeld, Frances M. K. Williams, D.J. Hart, Tim D. Spector, Nigel Arden, Gregory Livshits · 2013 · Osteoarthritis and Cartilage
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- Relationship Between Markers of Type II Collagen Metabolism and Tibiofemoral Joint Space Width Changes After ACL Injury and ReconstructionTimothy W. Tourville, Robert J. Johnson, James R. Slauterbeck, Shelly J. Naud, Bruce D. Beynnon · 2013 · The American Journal of Sports Medicine
- Clinical monitoring in osteoarthritis: BiomarkersVirginia B. Kraus, M.A. Karsdal · 2021 · Osteoarthritis and Cartilage
- The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort studyStaffan Larsson, Martin Englund, André Struglics, Stefan L. Lohmander · 2012 · Osteoarthritis and Cartilage
- The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritisIrina Kerna, Kalle Kisand, Siim Suutre, Maret Murde, Ann E. Tamm, Jaanika Kumm, Agu O. Tamm · 2013 · Joint Bone Spine
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- Assessment of Early Tibiofemoral Joint Space Width Changes After Anterior Cruciate Ligament Injury and ReconstructionTimothy W. Tourville, Robert J. Johnson, James R. Slauterbeck, Shelly J. Naud, Bruce D. Beynnon · 2013 · The American Journal of Sports Medicine
- Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind TrialYves Edgard Henrotin, Françis Berenbaum, Xavier Chevalier, Marc Marty, Pascal Richette, François Rannou · 2017 · BMC Musculoskeletal Disorders
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- The Need for Predictive, Prognostic, Objective and Complementary Blood-Based Biomarkers in Osteoarthritis (OA)Anne‐Christine Bay‐Jensen, Yves Edgard Henrotin, M.A. Karsdal, Ali Mobasheri · 2016 · EBioMedicine
- Posttraumatic osteoarthritis: what have we learned to advance osteoarthritis?Fiona E. Watt · 2020 · Current Opinion in Rheumatology
- Relationship between pre-radiographic cartilage damage following anterior cruciate ligament injury and biomarkers of cartilage turnover in clinical practice: a cross-sectional observational studyHiroaki Yoshida, Toshihisa Kojima, Kazutoshi Kurokouchi, Shigeo Takahashi, Hirokatsu Hanamura, Masayo Kojima, A. Robin Poole, Naoki Ishiguro · 2013 · Osteoarthritis and Cartilage
- Nanomedicines for chronic non-infectious arthritis: the clinician's perspectiveIsrael Rubinstein, Guy L. Weinberg · 2012 · Nanomedicine Nanotechnology Biology and Medicine
- Fibulin-3 fragments are prognostic biomarkers of osteoarthritis incidence in overweight and obese womenJ. Runhaar, Christelle Sanchez, Sébastien Taralla, Yves Edgard Henrotin, S. Bierma-Zeinstra · 2015 · Osteoarthritis and Cartilage
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- Therapeutic effects of statins on osteoarthritis: A reviewShirin Saberianpour, Samaneh Abolbashari, Mohamad Hadi Saeed Modaghegh, Maryam Saberi Karimian, Ali Hussein Eid, Thozhukat Sathyapalan, Amirhossein Sahebkar · 2022 · Journal of Cellular Biochemistry
- Analysis of the Trajectory of Osteoarthritis Development in a Mouse Model by Serial Near‐Infrared Fluorescence Imaging of Matrix Metalloproteinase ActivitiesAveri A. Leahy, Shadi Abdar Esfahani, Andrea Foote, Carrie K. Hui, Roshni S. Rainbow, Daisy S. Nakamura, Brian Tracey, Umar Mahmood, Li Zeng · 2014 · Arthritis & Rheumatology
- Clinical Application of the Basic Science of Articular Cartilage Pathology and TreatmentAnna Janine Schreiner, Aaron M. Stoker, Chantelle C. Bozynski, Keiichi Kuroki, James P. Stannard, James L. Cook · 2020 · The Journal of Knee Surgery
- Applications of Proteomics to Osteoarthritis, a Musculoskeletal Disease Characterized by AgingAli Mobasheri · 2011 · Frontiers in Physiology
- Imaging and Biochemical Markers for OsteoarthritisBenny Antony, Ambrish Singh · 2021 · Diagnostics
- Impact of physical activity and mechanical loading on biomarkers typically used in osteoarthritis assessment: current concepts and knowledge gapsNicole M. Cattano, Jeffrey B. Driban, Kenneth L. Cameron, Michael R. Sitler · 2016 · Therapeutic Advances in Musculoskeletal Disease
- A pilot study of peripheral blood DNA methylation models as predictors of knee osteoarthritis radiographic progression: data from the Osteoarthritis Initiative (OAI)Christopher M. Dunn, Michael C. Nevitt, John A. Lynch, Matlock Arizona Jeffries · 2019 · Scientific Reports
- Biomarkers for Osteoarthritis DiseasesJacob A. Braaten, Mark T. Banovetz, Nicholas N. DePhillipo, Filippo Familiari, Raffaella Russo, Nicholas I. Kennedy, Robert F. LaPrade · 2022 · Life
- An emerging micro-scale immuno-analytical diagnostic tool to see the unseen. Holding promise for precision medicine and P4 medicineNorberto A. Guzman, Daniel E. Guzman · 2015 · Journal of Chromatography B
- Review of Soluble Biomarkers of Osteoarthritis: Lessons From Animal ModelsCatherine Legrand, Cécile Lambert, Fanny Comblain, Christelle Sanchez, Yves Edgard Henrotin · 2016 · Cartilage
- Current status of catabolic, anabolic and inflammatory biomarkers associated with structural and symptomatic changes in the chronic phase of post-traumatic knee osteoarthritis– a systematic reviewOliver O’Sullivan, Peter Ladlow, Kat Steiner, Charles Hillman, Joanne Stocks, Alexander N. Bennett, Ana Maria Valdes, Stefan Kluzek · 2023 · Osteoarthritis and Cartilage Open
- Biochemical marker discovery, testing and evaluation for facilitating OA drug discovery and developmentAnne‐Christine Bay‐Jensen, Christian Schneider Thudium, Oreste Gualillo, Ali Mobasheri · 2017 · Drug Discovery Today
- Animal Models of Osteoarthritis Part 1–Preclinical Small Animal Models: Challenges and Opportunities for Drug DevelopmentJaqueline Lourdes Rios, Dora Sapède, Farida Djouad, Anna E. Rapp, Annemarie Lang, Jonathan D. Larkin, Christoph H. Ladel, Ali Mobasheri · 2022 · Current Protocols
- Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivoCatherine Legrand, Usman Ahmed, Attia Anwar, Kashif Rajpoot, Sabah Pasha, Cécile Lambert, Rose K. Davidson, Ian M. Clark, Paul John Thornalley, Yves Edgard Henrotin et al. · 2018 · Arthritis Research & Therapy
- Coll2-1 and Coll2-1NO2 as exemplars of collagen extracellular matrix turnover – biomarkers to facilitate the treatment of osteoarthritis?Ali Mobasheri, Cécile Lambert, Yves Edgard Henrotin · 2019 · Expert Review of Molecular Diagnostics
- Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significanceY.F. Ramos, Sarah Metrustry, N K Arden, Anne‐Christine Bay‐Jensen, Marian Beekman, Anton J.M. de Craen, L. Adrienne Cupples, Tõnu Esko, Εvangelos Εvangelou, David T. Felson et al. · 2014 · Journal of Medical Genetics
- Superoxide dismutase activity is significantly lower in end-stage osteoarthritic cartilage than non-osteoarthritic cartilageMasato Koike, Hidetoshi Nojiri, Hiroaki Kanazawa, Hiroto Q. Yamaguchi, Kei Miyagawa, Nana Nagura, Sammy Banno, Yoshiyuki Iwase, Hisashi Kurosawa, Kazuo Kaneko · 2018 · PLoS ONE
- Relationship between serum resistin, body fat and inflammatory markers in females with clinical knee osteoarthritisEman Mokbel Alissa, Layla S. Alzughaibi, Zuhair M. Marzouki · 2020 · The Knee
- Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9Yachen Li, Junjun Duan, Weicheng Lin, Jie Liu · 2023 · Open Medicine
- In vivo efficacy of fresh versus frozen osteochondral allografts in the goat at 6 months is associated with PRG4 secretionAndrea L. Pallante, Albert C. Chen, Michele Temple‐Wong, William D. Bugbee, Robert L. Sah · 2013 · Journal of Orthopaedic Research®
- Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkersShi Rui Seow, Sumaiyah Mat, Amalina Ahmad Azam, Nor Fadilah Rajab, Intan Safinar Ismail, Devinder Kaur Ajit Singh, Suzana Shahar, Maw Pin Tan, Françis Berenbaum · 2024 · Expert Reviews in Molecular Medicine
- Soluble biochemical markers of osteoarthritis: Are we close to using them in clinical practice?Ali Mobasheri, Anne‐Christine Bay‐Jensen, Oreste Gualillo, Jonanthan Larkin, Marc C. Levesque, Yves Edgard Henrotin · 2017 · Best Practice & Research Clinical Rheumatology
- A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis InitiativeL. Lourido, Vanesa Balboa Barreiro, Cristina Ruíz‐Romero, Ignacio Rego‐Pérez, María Camacho-Encina, Rocío Paz-González, Valentina Calamia, Natividad Oreiro, Peter Nilsson, Francisco Javier Blanco · 2021 · Osteoarthritis and Cartilage
- Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic reviewOliver O’Sullivan, Peter Ladlow, Kat Steiner, Dahria Kuyser, Omaima Ali, Joanne Stocks, Ana Maria Valdes, Alexander N. Bennett, Stefan Kluzek · 2023 · Osteoarthritis and Cartilage Open
- Bionanoconjugation for Proteomics applications — An overviewJoão Pinto da Costa, Rui Oliveira‐Silva, Ana L. Daniel‐da‐Silva, Rui Miguel Pinheiro Vitorino · 2014 · Biotechnology Advances
- Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learningAnna Swan, Kirsty L Hillier, Julia R. Smith, David Allaway, Susan Liddell, Jaume Bacardit, Ali Mobasheri · 2013 · BMC Musculoskeletal Disorders
- Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiativesYves Edgard Henrotin · 2012 · Osteoarthritis and Cartilage
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- Relationship between different serum cartilage biomarkers in the acute response to running and jumping in healthy male individualsMaren Dreiner, Tobias Munk, Frank Zaucke, Anna‐Maria Liphardt, Anja Niehoff · 2022 · Scientific Reports
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- Osteoarthritis UpdateChong‐Hyeon Yoon · 2012 · Korean Journal of Medicine
- A dissimilarity-based multiple classifier system for trabecular bone texture in detection and prediction of progression of knee osteoarthritisTomasz Woloszynski, Paweł Podsiadło, Gwidon Stachowiak, Marek W. Kurzynski · 2012 · Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine
- Relationship between synovial fluid biomarkers of articular cartilage metabolism and the patient's perspective of outcome depends on the severity of articular cartilage damage following ACL traumaScott M. Wasilko, Timothy W. Tourville, Michael DeSarno, James R. Slauterbeck, Robert J. Johnson, André Struglics, Bruce D. Beynnon · 2015 · Journal of Orthopaedic Research®
- Soluble biomarkers development in osteoarthritis: from discovery to personalized medicineYves Edgard Henrotin, Christelle Sanchez, Anne M. Cornet, Joachim Van de Put, Pierre Douette, Myriam Gharbi · 2015 · Biomarkers
- Cyclic Phosphatidic Acid Relieves Osteoarthritis SymptomsMari Gotoh, Aya Nagano, Ryoko Tsukahara, Hiromu Murofushi, Toshiro Morohoshi, Kazuyuki Otsuka, Kimiko Murakami‐Murofushi · 2014 · Molecular Pain
- Serum proteomic biomarkers diagnostic of knee osteoarthritisVirginia B. Kraus, Alexander Reed, Erik J. Soderblom, Yvonne M. Golightly, Amanda E. Nelson, Yi‐Ju Li · 2023 · Osteoarthritis and Cartilage
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- Magnetic Capture of a Molecular Biomarker from Synovial Fluid in a Rat Model of Knee OsteoarthritisElena G. Yarmola, Yash Y. Shah, David P. Arnold, Jon Dobson, Kyle D. Allen · 2015 · Annals of Biomedical Engineering
- EUROVISCO Guidelines for the Design and Conduct of Clinical Trials Assessing the Disease-Modifying Effect of Knee ViscosupplementationYves Edgard Henrotin, Xavier Chevalier, Raghu Raman, Pascal Richette, Jordi Montfort, Jörg Jerosch, D. Baron, Hervé Bard, Yannick Carrillon, Alberto Migliore et al. · 2018 · Cartilage
- Relationship between synovial fluid ARGS‐aggrecan fragments, cytokines, MMPs, and TIMPs following acute ACL injury: A cross‐sectional studyTimothy W. Tourville, Matthew E. Poynter, Michael DeSarno, André Struglics, Bruce D. Beynnon · 2015 · Journal of Orthopaedic Research®
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