Clinical Use of Quantitative Computed Tomography and Peripheral Quantitative Computed Tomography in the Management of Osteoporosis in Adults: The 2007 ISCD Official Positions
Abstract
The International Society for Clinical Densitometry (ISCD) has developed Official Positions for the clinical use of dual-energy X-ray absorptiometry (DXA) and non-DXA technologies. While only DXA can be used for diagnostic classification according to criteria established by the World Health Organization, DXA and some other technologies may predict fracture risk and be used to monitor skeletal changes over time. ISCD task forces reviewed the evidence for clinical applications of non-DXA techniques and presented reports with recommendations at the 2007 ISCD Position Development Conference. Here we present the ISCD Official Positions for quantitative computed tomography (QCT) and peripheral QCT (pQCT), with supporting medical evidence, rationale, controversy, and suggestions for further study. QCT is available for bone mineral density measurements at the spine, hip, forearm, and tibia. The ISCD Official Positions presented here focus on QCT of the spine and pQCT of the forearm. Measurements at the hip may have clinical relevance, as this is an important fracture site; however, due to limited medical evidence, definitive advice on its use in clinical practice cannot be provided until more data emerge.
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Current QCT-derived T-scores do not directly correspond to DXA T-scores, limiting QCT clinical utility.
“Current QCT-derived T-scores do not directly correspond to DXA T-scores, limiting QCT clinical utility (21).”
From Opportunistic screening for osteoporosis using abdominal computed tomography scans obtained for other indications (2013) · cites this paper as [21]
Quantitative CT is more labor-intensive; requires an imaging phantom or angle-corrected ROI measurement of bone, muscle, and fat at multiple levels; and involves additional money, time, and radiation exposure.
“It should not be confused with QCT, which is more labor-intensive; requires an imaging phantom or angle-corrected ROI measurement of bone, muscle, and fat at multiple levels (21); and involves additional money, time, and radiation exposure.”
From Opportunistic screening for osteoporosis using abdominal computed tomography scans obtained for other indications (2013) · cites this paper as [21]
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- Authors
- Engelke, K., Adams, J. E., Armbrecht, G., Augat, P., Bogado, C. E., Bouxsein, M. L., Felsenberg, D., Ito, M., Prevrhal, S., Hans, D. B., & Lewiecki, E. M.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Manchester (GB)
- Charité – Universitätsmedizin Berlin (DE)
- Berufsgenossenschaftliche Unfallklinik Murnau (DE)
- Beth Israel Deaconess Medical Center (US)
- Nagasaki University Hospital (JP)
- University of California, San Francisco (US)
- University Hospital of Geneva (CH)
- New Mexico Clinical Research & Osteoporosis Center (US)
- Corresponding author
- Engelke, Klaus
- Venue
- Journal of Clinical Densitometry
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 11
- Issue
- 1
- Pages
- 123-162
- ISSN
- 1094-6950 (ISSN-L)
- OpenAlex
- W2156414583
- Cited by
- 617
- References
- 279
- Citations by year
- 2026: 40 · 2025: 48 · 2024: 50 · 2023: 63 · 2022: 45 · 2021: 38 · 2020: 32 · 2019: 23 · 2018: 35 · 2017: 30 · 2016: 40 · 2015: 23 · 2014: 21 · 2013: 32 · 2012: 19
- FWCI
- 24.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Densitometry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Keywords
- osteoporosis, quantitative computed tomography, peripheral quantitative computed tomography, bone mineral density, fracture risk prediction, osteoporosis diagnosis, osteoporosis monitoring, spine, forearm, hip
- MeSH terms
- Adult, Calibration, Femur, Forearm, Humans, Osteoporosis, Radiographic Image Interpretation, Computer-Assisted, Societies, Medical, Tomography, X-Ray Computed, Bone Density, Spinal Fractures, Fractures, Bone
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