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Cited by 493

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Prevalence of Osteonecrosis of the Jaw in Patients With Oral Bisphosphonate Exposure

Open access
Lo, Joan C., O'Ryan, Felice S., Gordon, Nancy P., Yang, Jingrong, Hui, Rita L., Martin, Daniel, Hutchinson, Matthew, Lathon, Phenius V., Sanchez, Gabriela, Silver, Paula, Chandra, Malini, McCloskey, Carolyn A., Staffa, Judy A., Willy, Mary, Selby, Joe V., Go, Alan S.·2010·Journal of Oral and Maxillofacial Surgery
DOI 10.1016/j.joms.2009.03.050
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Abstract

Purpose: Osteonecrosis of the jaw (ONJ) is a serious complication associated with bisphosphonate therapy, but its epidemiology in the setting of oral bisphosphonate therapy is poorly understood. This study examined the prevalence of ONJ among persons receiving chronic oral bisphosphonate therapy. Materials and Methods: We mailed a survey to 13,946 members who received chronic oral bisphosphonate therapy as of 2006 within a large integrated healthcare delivery system in Northern California. Respondents who reported ONJ, exposed bone or gingival sores, moderate periodontal disease, persistent symptoms or complications following dental procedures were invited for examination or to have their dental records reviewed. ONJ was defined as exposed bone (>8 weeks) in the maxillofacial region in the absence of prior radiation therapy. Results: Among 8,572 survey respondents (71±9 years, 93% female), 2,159 (25%) reported pertinent dental symptoms. Of these 2,159 patients, 1,005 were examined and an additional 536 provided dental records. Nine ONJ cases were identified, representing a prevalence of 0.10% (95% CI 0.05–0.20%) among survey respondents. Five cases occurred spontaneously (three in palatal tori). Four cases occurred in prior extraction sites. Three additional patients had mandibular osteomyelitis (two following extraction and one with implant failure) but without exposed bone. Seven patients had bone exposure that did not fulfill criteria for ONJ. Conclusion: Osteonecrosis of the jaw occurred in 1 in 952 survey respondents with oral bisphosphonate exposure (minimum prevalence 1 in 1,537 among entire mailed cohort). A similar number had select features concerning for ONJ that did not meet criteria. This study provides important data on the spectrum of jaw complications among patients with oral bisphosphonate exposure.

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Metadata

Authors
Lo, J. C., O'Ryan, F. S., Gordon, N. P., Yang, J., Hui, R. L., Martin, D., Hutchinson, M., Lathon, P. V., Sanchez, G., Silver, P., Chandra, M., McCloskey, C. A., Staffa, J. A., Willy, M., Selby, J. V., & Go, A. S.
Venue
Journal of Oral and Maxillofacial Surgery
Publisher
Elsevier BV
Published
2010-02
Volume
68
Issue
2
Pages
243-253
ISSN
0278-2391 (ISSN-L)
DOI
10.1016/j.joms.2009.03.050
OpenAlex
W2118377751
Cited by
493
References
35
FWCI
16.11
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Prevalence of Osteonecrosis of the Jaw in Patients With Oral Bisphosphonate Exposure. https://app.cochat.ai/papers/10.1016/j.joms.2009.03.050
The paper
Lo, J. C., O'Ryan, F. S., Gordon, N. P., Yang, J., Hui, R. L., Martin, D., Hutchinson, M., Lathon, P. V., Sanchez, G., Silver, P., Chandra, M., McCloskey, C. A., Staffa, J. A., Willy, M., Selby, J. V., & Go, A. S. (2010). Prevalence of Osteonecrosis of the Jaw in Patients With Oral Bisphosphonate Exposure. Journal of Oral and Maxillofacial Surgery. https://doi.org/10.1016/j.joms.2009.03.050

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.