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Cited by 168Polymer Surface Interaction StudiesBone Tissue Engineering MaterialsSurface Treatment and Coatings

Polydopamine-assisted surface modification for orthopaedic implants

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Jia, Luanluan, Han, Fengxuan, Wang, Huan, Zhu, Caihong, Guo, Qianping, Li, Jiaying, Zhao, Zhongliang, Zhang, Qiang +2 more·2019·Journal of Orthopaedic Translation
DOI 10.1016/j.jot.2019.04.001PMC PMC6551362
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Abstract

Along with the massive use of implants in orthopaedic surgeries in recent few decades, there has been a tremendous demand for the surface modification of the implants to avoid surgery failure and improve their function. Polydopamine (PDA), being able to adhere to almost all kinds of substrates and possessing copious functional groups for covalently immobilizing biomolecules and anchoring metal ions, has been widely used for surface modification of materials since its discovery in the last decade. PDA and its derivatives can be used for the surface modification of orthopaedic implants to modulate cellular responses, including cell spreading, migration, proliferation, and differentiation, and may thereby enhance the function of existing implants. In addition, the osseointegration and antimicrobial properties of orthopaedic implants may also be improved by PDA-based coatings. The aim of this review is to provide a brief overview of current advances of surface modification technologies for orthopaedic implants using PDA and its derivatives as a medium. Given the versatility of PDA-based adhesion, such PDA-assisted surface modification technologies will certainly benefit the development of new orthopaedic implants. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: Surface treatments of orthopaedic implants, which are normally inert materials, are essential for their performance in vivo. This review summarizes recent advances in the surface modification of orthopaedic implants using facile and highly versatile techniques based on the use of polydopamine (PDA) and its derivatives.

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  • Coating adhesion durability, wear resistance, interfacial degradation, batch-to-batch reproducibility, and the biological safety of degradation products remain critical issues before PDA-modified implants or scaffolds can be considered clinically mature.

    “In particular, coating adhesion durability, wear resistance, interfacial degradation, batch-to-batch reproducibility, and the biological safety of degradation products remain critical issues before PDA-modified implants or scaffolds can be considered clinically mature.36,40,41”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [40]

    The Biocompatibility and biodegradability section (page unavailable) says biodegradability is important for clinical applications, and Summary and perspectives (page unavailable) calls for further research on PDA-modified implants. But the paper does not identify wear resistance, interfacial degradation, batch-to-batch reproducibility, or the safety of degradation products as unresolved clinical issues; its Introduction instead describes PDA coatings as having durable stability. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • In vitro degradation studies have shown that under oxidative conditions (0.1 mmol L−1 H2O2, pH 7.4, 37 °C), PDA film thickness decreases by approximately 42% within 30 days.

    “In vitro degradation studies have shown that under oxidative conditions (0.1 mmol L−1 H2O2, pH 7.4, 37 °C), PDA film thickness decreases by approximately 42% within 30 days.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [40]

    The Biocompatibility and biodegradability section (page unavailable) says PDA nanoparticles have been observed to degrade in hydrogen peroxide, as shown by colour fading. It does not report a decrease in PDA film thickness, a 42% change over 30 days, or the stated concentration, pH and temperature. The Preparation of PDA section discusses coating thickness during deposition, not degradation. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • The in vivo degradation of PDA exhibits a characteristic two-stage process, described as 'surface etching followed by interlayer delamination.'

    “The in vivo degradation of PDA exhibits a characteristic two-stage process, described as “surface etching followed by interlayer delamination.””

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [40]

    The Biocompatibility and biodegradability section reports that PDA nanoparticles degraded in hydrogen peroxide and that melanin implants were almost completely degraded after eight weeks in vivo. It does not describe PDA degradation in vivo as a two-stage process involving surface etching and interlayer delamination; searches for that phrase and for related degradation terms found no such passage. Page numbers were not available in our copy. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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References 80 · Cited by 168

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Authors
Jia, L., Han, F., Wang, H., Zhu, C., Guo, Q., Li, J., Zhao, Z., Zhang, Q., Zhu, X., & Li, B.
Affiliations
Soochow University (CN)
Corresponding author
  • Zhu, Xuesong
  • Li, Bin
ORCID
Venue
Journal of Orthopaedic Translation
Publisher
Elsevier BV
Published
2019-04
Volume
17
Pages
82-95
ISSN
2214-031X (ISSN-L)
DOI
10.1016/j.jot.2019.04.001
PMC
PMC6551362
OpenAlex
W2941843716
Cited by
168
References
80
Citations by year
2026: 9 · 2025: 17 · 2024: 31 · 2023: 26 · 2022: 35 · 2021: 25 · 2020: 21 · 2019: 4
FWCI
2.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Orthopaedic Translation (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (31872748, 31500779, 81471790, 31530024, 81672213)
  • Jiangsu Provincial Special Program of Medical Science (BL2012004)
  • China Postdoctoral Science Foundation (2016M590500, 2017T100398)
  • Jiangsu Planned Projects for Postdoctoral Research Funds (1601269C)
  • the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
Keywords
polydopamine, orthopedic implants, surface modification, biomaterial coatings, osseointegration, antimicrobial coatings, cell adhesion, cell proliferation and differentiation, implant failure, biomolecule immobilization

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