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The Outcome of Complex Regional Pain Syndrome Type 1: A Systematic Review
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Unlabelled The purpose of this systematic review was to examine the outcome of complex regional pain syndrome (CRPS) type 1. We searched MEDLINE, Embase, and PsycINFO for relevant studies and included 18 studies, with 3,991 participants, in this review. The following data were extracted: study details, measurement tools used, and rates or severity scores for the symptoms/signs of CRPS at baseline and follow-up, or in groups of patients with different disease durations. A quality assessment revealed significant limitations in the literature, with many studies using different diagnostic criteria. The 3 prospective studies demonstrated that for many patients, symptoms improve markedly within 6 to 13 months of onset. The 12 retrospective studies had highly heterogeneous findings, documenting lasting impairments in many patients. The 3 cross-sectional studies showed that rates of pain and sensory symptoms were highest among those with the longest duration of CRPS. Additionally, most studies showed that motor symptoms (stiffness and weakness) were the most likely to persist whereas sudomotor and vasomotor symptoms were the most likely to improve. Overall, this suggests that some CRPS patients make a good early recovery whereas others develop lasting pain and disability. As yet little is known about the prognostic factors that might differentiate between these groups.Perspective We found evidence that many CRPS patients recover within 6 to 13 months, but a significant number experience some lasting symptoms, and some experience chronic pain and disability. The quality of the evidence was poor. Future research should examine the factors associated with recovery and identify those at risk of poor outcomes.
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“many people have persistent CRPS with severe functional impairment and decreased quality of life [3, 4].”
From Symptom reduction and improved function in chronic CRPS type 1 after 12-week integrated, interdisciplinary therapy (2019) · cites this paper as [3]
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Metadata
- Authors
- Bean, D. J., Johnson, M. H., & Kydd, R. R.
- Affiliations
- University of Auckland (NZ)
- Corresponding author
- Bean, Debbie J.
- Venue
- The Journal of Pain
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 15
- Issue
- 7
- Pages
- 677-690
- ISSN
- 1526-5900 (ISSN-L)
- OpenAlex
- W2033223451
- Cited by
- 137
- References
- 54
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 12 · 2021: 9 · 2020: 15 · 2019: 13 · 2018: 16 · 2017: 15 · 2016: 11 · 2015: 13 · 2014: 2
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
- Keywords
- complex regional pain syndrome type I, chronic pain, disability, disease duration, motor symptoms, sensory symptoms, prognosis, recovery
- MeSH terms
- Humans, Reflex Sympathetic Dystrophy, Databases, Bibliographic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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