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Cited by 276Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsPain Management and Treatment

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy

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Wallace, Mark S., Marcotte, Thomas D., Umlauf, Anya, Gouaux, Ben, Atkinson, Joseph H.·2015·The Journal of Pain
DOI 10.1016/j.jpain.2015.03.008PMC PMC5152762
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Abstract

Unlabelled A randomized, double-blinded, placebo controlled crossover study was conducted in 16 patients with painful diabetic peripheral neuropathy to assess the short-term efficacy and tolerability of inhaled cannabis. In a crossover design, each participant was exposed to 4 single dosing sessions of placebo or to low (1% tetrahydrocannabinol [THC]), medium (4% THC), or high (7% THC) doses of cannabis. Baseline spontaneous pain, evoked pain, and cognitive testing were performed. Subjects were then administered aerosolized cannabis or placebo and the pain intensity and subjective "highness" score was measured at 5, 15, 30, 45, and 60 minutes and then every 30 minutes for an additional 3 hours. Cognitive testing was performed at 5 and 30 minutes and then every 30 minutes for an additional 3 hours. The primary analysis compared differences in spontaneous pain over time between doses using linear mixed effects models. There was a significant difference in spontaneous pain scores between doses (P < .001). Specific significant comparisons were placebo versus low, medium, and high doses (P = .031, .04, and <.001, respectively) and high versus low and medium doses (both P < .001). There was a significant effect of the high dose on foam brush and von Frey evoked pain (both P < .001). There was a significant negative effect (impaired performance) of the high dose on 2 of the 3 neuropsychological tests (Paced Auditory Serial Addition Test, Trail Making Test Part B.Perspective This small, short-term, placebo-controlled trial of inhaled cannabis demonstrated a dose-dependent reduction in diabetic peripheral neuropathy pain in patients with treatment-refractory pain. This adds preliminary evidence to support further research on the efficacy of the cannabinoids in neuropathic pain.

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Research works printed but not linked: 2

  1. Grlic, 1962, A comparative study on some chemical and biological characteristics of various samples of cannabis resin, Bull Narc, 3, 37
  2. Robbins, 1981, National Institute of Mental Health Diagnostic Interview Schedule, Arch Gen Psychiatry, 140, 201

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Metadata

Authors
Wallace, M. S., Marcotte, T. D., Umlauf, A., Gouaux, B., & Atkinson, J. H.
Affiliations
University of California San Diego (US)
Corresponding author
Wallace, Mark S.
ORCID
Venue
The Journal of Pain
Publisher
Elsevier BV
Published
2015-07
Volume
16
Issue
7
Pages
616-627
ISSN
1526-5900 (ISSN-L)
DOI
10.1016/j.jpain.2015.03.008
PMC
PMC5152762
OpenAlex
W2081629704
Cited by
276
References
55
Citations by year
2026: 14 · 2025: 42 · 2024: 31 · 2023: 21 · 2022: 35 · 2021: 23 · 2020: 19 · 2019: 22 · 2018: 36 · 2017: 19 · 2016: 11 · 2015: 3
FWCI
16.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Pain (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (P30MH062512)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
inhaled cannabis, tetrahydrocannabinol, diabetic peripheral neuropathy, neuropathic pain, refractory pain, dose-dependent analgesia, spontaneous pain, evoked pain, cognitive impairment, tolerability, cannabinoids
MeSH terms
Administration, Inhalation, Aged, Analysis of Variance, Cognition, Depression, Diabetic Neuropathies, Double-Blind Method, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Pain Measurement, Dronabinol, Time Factors, Treatment Outcome, Cross-Over Studies, Analgesics, Non-Narcotic

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