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Cited by 31Anesthesia and Pain ManagementPain Management and TreatmentPain Management and Opioid Use

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Efficacy of transdermal nitroglycerin combined with etodolac for the treatment of chronic post-thoracotomy pain: An open-label prospective clinical trial

Open access
Glantz, Lucio, Godovic, Galina, Lekar, Margarita, Kramer, Mordechai, Eidelman, Leonid A·2004·Journal of Pain and Symptom Management
DOI 10.1016/j.jpainsymman.2003.06.009
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Abstract

Chronic post-thoracotomy pain (CPP) is associated with surgical intercostal nerve injury. Like other forms of neuropathic pain, there is no ideal treatment. Nitroglycerin (NTG) has been found efficacious in acute pain, but has not been tested for chronic pain with neuropathic characteristics. The present study investigated the efficacy of NTG combined with the nonsteroidal anti-inflammatory drug etodolac for the treatment of CPP. Thirty of 129 patients who underwent thoracotomy within an 18-month period had moderate to severe pain that did not respond to etodolac. NTG, 5 mg/day, was added to the treatment. A significant reduction in VAS was observed on day 14 of treatment (from 66.7 +/- 11 to 42.1 +/- 5, P< 0.05). Similar changes were noted in breakthrough pain intensity and and sleep efficiency. The only side effect was mild headache, which was self-limited to the first few days of NTG administration. We conclude that NTG added to etodolac appears to be effective for the treatment of CPP, with minimal side effects. Further randomized blinded studies are required.

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Crossref · 10.1016/j.jpainsymman.2003.06.009

Cites

23 of 23 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Glantz, L., Godovic, G., Lekar, M., Kramer, M., & Eidelman, L. A.
Affiliations
Rabin Medical Center (IL)
Corresponding author
Glantz, Lucio
ORCID
Kramer, Mordechai
Venue
Journal of Pain and Symptom Management
Publisher
Elsevier BV
Published
2004-03
Volume
27
Issue
3
Pages
277-281
ISSN
0885-3924 (ISSN-L)
DOI
10.1016/j.jpainsymman.2003.06.009
OpenAlex
W2046912157
Cited by
31
References
23
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2018: 3 · 2015: 3 · 2014: 4 · 2012: 2
FWCI
1.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Pain and Symptom Management (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
chronic post-thoracotomy pain, transdermal nitroglycerin, etodolac, neuropathic pain, intercostal nerve injury, thoracotomy, nonsteroidal anti-inflammatory drugs, breakthrough pain, sleep efficiency, headache side effects
MeSH terms
Administration, Cutaneous, Aged, Anti-Inflammatory Agents, Non-Steroidal, Drug Therapy, Combination, Female, Nitroglycerin, Humans, Male, Middle Aged, Postoperative Pain, Prospective Studies, Thoracotomy, Vasodilator Agents, Etodolac

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.