The DOI matches its Crossref record; 35 of the 37 references it cites were found in a registry or an index.
Cannabis Use in HIV for Pain and Other Medical Symptoms
Open accessAbstract
Despite the major benefits of antiretroviral therapy on survival during HIV infection, there is an increasing need to manage symptoms and side effects during long-term drug therapy. Cannabis has been reported anecdotally as being beneficial for a number of common symptoms and complications in HIV infections, for example, poor appetite and neuropathy. This study aimed to investigate symptom management with cannabis. Following Ethics Committee approval, HIV-positive individuals attending a large clinic were recruited into an anonymous cross-sectional questionnaire study. Up to one-third (27%, 143/523) reported using cannabis for treating symptoms. Patients reported improved appetite (97%), muscle pain (94%), nausea (93%), anxiety (93%), nerve pain (90%), depression (86%), and paresthesia (85%). Many cannabis users (47%) reported associated memory deterioration. Symptom control using cannabis is widespread in HIV outpatients. A large number of patients reported that cannabis improved symptom control.
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“Each study involved whole plant cannabis in inhaled or oral formats, with patients reporting moderate relief.”
From Clinical Practice Guidelines for Cannabis and Cannabinoid-Based Medicines in the Management of Chronic Pain and Co-Occurring Conditions (2024) · cites this paper as [88]
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“An anonymous cross-sectional questionnaire study revealed that as many as one-third of patients suffering from HIV have used cannabis to treat symptoms.138”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [138]
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“Three cross-sectional studies also report antidepressant effects of CBM.82,97,98”
From Clinical Practice Guidelines for Cannabis and Cannabinoid-Based Medicines in the Management of Chronic Pain and Co-Occurring Conditions (2024) · cites this paper as [97]
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“Among the symptoms improved following cannabis were appetite (97% reported improvement), pain (improved in 94% of the patients with pain), nausea (93% reported improvement) and anxiety (93% reported improvement).138”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [138]
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Citations
Cites
Changing patterns of mortality across Europe in patients infected with HIV-1
Mocroft, A., Vella, S., Benfield, T., Chiesi, A., Miller, V., Gargalianos, P., Monforte, A. D., Yust, I., Bruun, J., Phillips, A. N., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03201-2 · Cited by 1,269
Adverse effects of antiretroviral therapy
Carr, A. D., & Cooper, D. A. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02854-3 · Cited by 1,076
The effects of cannabinoids on the brain
Ameri, A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00087-2 · Cited by 825
Iversen, L. L. (2003) · Brain · doi:10.1093/brain/awg143 · Cited by 751
Cannabidiol: An Overview of Some Pharmacological Aspects
Mechoulam, R., Parker, L. A., & Gallily, R. (2002) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.2002.tb05998.x · Cited by 530
Wade, D. T., Robson, P., House, H., Makela, P., & Aram, J. (2003) · Clinical Rehabilitation · doi:10.1191/0269215503cr581oa · Cited by 441
An analgesia circuit activated by cannabinoids
Meng, I. D., Manning, B. H., Martin, W. J., & Fields, H. L. (1998) · Nature · doi:10.1038/26481 · Cited by 411
The analgesic properties of delta‐9‐tetrahydrocannabinol and codeine
Noyes, R., Brunk, S. F., Avery, D. H., & Canter, A. (1975) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt197518184 · Cited by 378
Antiemetic Effect of Delta-9-Tetrahydrocannabinol in Patients Receiving Cancer Chemotherapy
Sallan, S. E., Zinberg, N. E., & Frei, E. (1975) · New England Journal of Medicine · doi:10.1056/nejm197510162931603 · Cited by 364
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
Pryce, G., Ahmed, Z., Hankey, D. J. R., Jackson, S. J., Croxford, J. L., Pocock, J. M., Ledent, C. A., Petzold, A., Thompson, A. J., Giovannoni, G., et al. (2003) · Brain · doi:10.1093/brain/awg224 · Cited by 345
Cannabinoids as Therapeutic Agents
(2019) · Chapman & Hall/CRC eBooks · doi:10.1201/9780429260667 · Cited by 311
The Guy's Neurological Disability Scale (GNDS): a new disability measure for multiple sclerosis
Sharrack, B., & Hughes, R. A. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500406 · Cited by 290
Delta-9-Tetrahydrocannabinol as an Antiemetic in Cancer Patients Receiving High-Dose Methotrexate
Chang, A. E., Shiling, D. J., Stillman, R. C., Goldberg, N. H., Seipp, C. A., Barofsky, I., Simon, R. M., & Rosenberg, S. A. (1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-91-6-819 · Cited by 258
Peripheral neuropathic pain—a multidimensional burden for patients
Meyer-Rosberg, K., Kvarnström, A., Kinnman, E., Gordh, T., Nordfors, L., & Kristofferson, A. (2001) · European Journal of Pain · doi:10.1053/eujp.2001.0259 · Cited by 247
Abrams, D. I., Hilton, J. F., Leiser, R. J., Shade, S. B., Elbeik, T. A., Aweeka, F. T., Benowitz, N. L., Bredt, B. M., Kosel, B., Aberg, J. A., et al. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-4-200308190-00008 · Cited by 238
Cannabinoids and brain injury: therapeutic implications
Mechoulam, R. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02276-1 · Cited by 229
Recent clinical experience with dronabinol
Plasse, T. F., Gorter, R. W., Krasnow, S. H., Lane, M., Shepard, K. V., & Wadleigh, R. G. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90385-f · Cited by 225
HIV-associated sensory neuropathies
Keswani, S. C., Pardo, C. A., Cherry, C. L., Höke, A., & McArthur, J. C. (2002) · AIDS · doi:10.1097/00002030-200211080-00002 · Cited by 218
Cannabis use for chronic non-cancer pain: results of a prospective survey
Ware, M. A., Doyle, C. R., Woods, R., Lynch, M. E., & Clark, A. J. (2003) · Pain · doi:10.1016/s0304-3959(02)00400-1 · Cited by 185
Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy
Rice, A. S. C., Farquhar-Smith, W. P., & Nagy, I. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0362 · Cited by 183
Cannabinoids: a real prospect for pain relief
Iversen, L. L. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00120-5 · Cited by 162
Evaluation of Intramuscular Levonantradol and Placebo in Acute Postoperative Pain
Jain, A. K., Ryan, J. R., McMahon, F. G., & Smith, G. (1981) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1981.tb02610.x · Cited by 150
Different Effects of Nabilone and Cannabidiol on Binocular Depth Inversion in Man
Leweke, F. M., Schneider, U., Radwan, M., Schmidt, E., & Emrich, H. M. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00201-x · Cited by 150
Pain relief with oral cannabinoids in familial Mediterranean fever
Holdcroft, A., Smith, M., Jacklin, A., Hodgson, H. J. F., Smith, B., Newton, M., & Evans, F. J. (1997) · Anaesthesia · doi:10.1111/j.1365-2044.1997.139-az0132.x · Cited by 129
Self-citationEffect of a nitrogen analog of tetrahydrocannabinol on cancer pain
Staquet, M. J., Gantt, C., & Machin, D. (1978) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1978234397 · Cited by 87
Taylor, D. R., & Hall, W. (2003) · Internal Medicine Journal · doi:10.1046/j.1445-5994.2003.00401.x · Cited by 58
The Endocannabinoid System and Huntingtons Disease
Lastres‐Becker, I., Miguel, R., & Fernández‐Ruíz, J. (2003) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007033482751 · Cited by 54
Delta-9-Tetrahydrocannabinol in Cancer Chemotherapy: Research Problems and Issues
Carey, M. P., Burish, T. G., & Brenner, D. E. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-99-1-106 · Cited by 50
Cannabis Use by Persons Living with HIV/AIDS: Patterns and Prevalence of Use
Ware, M. A., Rueda, S., Singer, J., & Kilby, D. (2003) · Journal of Cannabis Therapeutics · doi:10.1300/j175v03n02_02 · Cited by 49
Δ9-Tetrahydrocannabinol in Clinical Oncology
Poster, D. S. (1981) · JAMA · doi:10.1001/jama.1981.03310450039020 · Cited by 41
Medical Use of Recreational Drugs by AIDS Patients
Dansak, D. A. (1997) · Journal of Addictive Diseases · doi:10.1300/j069v16n03_03 · Cited by 30
Marijuana Use in HIV-Positive and AIDS Patients
Sidney, S. (2001) · Journal of Cannabis Therapeutics · doi:10.1300/j175v01n03_04 · Cited by 18
Non-nucleoside reverse transcriptase inhibitors—an overview
Bell, C., Matthews, G. V., & Nelson, M. R. (2003) · International Journal of STD & AIDS · doi:10.1258/095646203321156827 · Cited by 12
Cannabis Therapeutics in HIV/AIDS
Russo, E. B. (2012) · Routledge eBooks · doi:10.4324/9780203049105 · Cited by 6
Cannabis Therapeutics in HIV/AIDS
Gomez-Beloz, A. (2003) · Economic Botany · doi:10.1663/0013-0001(2003)057[0425:bredfa]2.0.co;2 · Cited by 3
Research works printed but not linked: 1
- Prestage GS, Kippax S, Grulich A. Use of treatments and health enhancement behaviours among HIV positive men in a cohort of homosexually active men. XI International Conference on AIDS, Vancouver, BC, Canada, July 1996. Abstract thD 5181.
Cited by
Sorted by citations
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077
Gobbi, G., Bambico, F. R., Mangieri, R. A., Bortolato, M., Campolongo, P., Solinas, M., Cassano, T., Morgese, M. G., Debonnel, G., Duranti, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509591102 · Cited by 692
Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial
Abrams, D. I., Jay, C. A., Shade, S. B., Vizoso, H., Reda, H., Press, S., Kelly, M. E., Rowbotham, M. C., & Petersen, K. L. (2007) · Neurology · doi:10.1212/01.wnl.0000253187.66183.9c · Cited by 598
Pain and Depression: A Systematic Review
IsHak, W. W., Wen, R. Y., Naghdechi, L., Vanle, B., Dang, J., Knosp, M., Dascal, J., Marcia, L., Gohar, Y., Eskander, L., et al. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000198 · Cited by 498
Cannabis and anxiety: a critical review of the evidence
Crippa, J. A., Zuardi, A. W., Martín‐Santos, R., Bhattacharyya, S., Atakan, Z., McGuire, P., & Fusar‐Poli, P. (2009) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.1048 · Cited by 509
Metadata
- Authors
- Woolridge, E., Barton, S., Samuel, J., Osorio, J., Dougherty, A., & Holdcroft, A.
- Affiliations
- Imperial College London (GB)
- Chelsea and Westminster Hospital (GB)
- Chelsea and Westminster Hospital NHS Foundation Trust (GB)
- ORCID
- Barton, Simon
- Venue
- Journal of Pain and Symptom Management
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 29
- Issue
- 4
- Pages
- 358-367
- ISSN
- 0885-3924 (ISSN-L)
- OpenAlex
- W2115233771
- Cited by
- 208
- References
- 37
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 4 · 2023: 21 · 2022: 12 · 2021: 18 · 2020: 5 · 2019: 11 · 2018: 8 · 2017: 10 · 2016: 9 · 2015: 15 · 2014: 11 · 2013: 7 · 2012: 9
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain and Symptom Management (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- cannabis use, HIV infection, symptom management, neuropathic pain, neuropathy, appetite, nausea, anxiety, depression, paresthesia, antiretroviral therapy adverse effects, memory impairment
- MeSH terms
- Adult, Aged, Cannabinoids, Cannabis, Cross-Sectional Studies, Data Collection, Drug Therapy, Female, United Kingdom, Humans, Male, Phytotherapy, Middle Aged, Nausea, Pain, Severity of Illness Index, HIV Infections, Comorbidity, Plant Preparations
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