The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Prevalence of Fatigue in Patients With Cancer: A Systematic Review and Meta-Analysis
Open accessAbstract
Context Fatigue is a particularly common and troubling symptom that has a negative impact on quality of life throughout all phases of treatment and stages of the illness among patients with cancer.Objectives The objective of this meta-analysis is to examine the present status of fatigue prevalence in patients with cancer.Methods The following databases were searched: PubMed, MEDLINE, EMBASE, PsycINFO, Cochrane Library, from inception up to February 2020. Prevalence rates were pooled with meta-analysis using a random-effects model. Heterogeneity was tested using I-squared (I 2) statistics.Results A total of 129 studies (N = 71,568) published between 1993 and 2020 met the inclusion criteria. The overall prevalence of fatigue was 49% (34,947 of 71,656 participants, 95% CI = 45-53) with significant heterogeneity between studies (P < 0.000; τ 2 = 0.0000; I 2 = 98.88%). Subgroup analyses show that the prevalence of fatigue related to type of cancer ranged from 26.2% in patients with gynecological cancer to 56.3% in studies that included mixed types of cancer. In advanced cancer stage patients, the highest prevalence of fatigue (60.6%) was reported. Fatigue prevalence rates were 62% during treatment and 51% during mixed treatment status. The prevalence of fatigue decreased from 64% in studies published from 1996 to 2000 to 43% in studies published from 2016 to 2020. Metaregression identified female gender as a significant moderator for higher prevalence of fatigue, whereas mean age is not associated with fatigue.Conclusion This meta-analysis highlights the importance of developing optimal monitoring strategies to reduce fatigue and improve the quality of life of patients with cancer.
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“and is particularly relevant in a cancer context, where stress and symptoms of depression and anxiety are common [33,53-55].”
From Co-Designing the MOSAIC mHealth App With Breast Cancer Survivors: User-Centered Design Approach (2024) · cites this paper as [55]
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Management of common clinical problems experienced by survivors of cancer
Emery, J., Butow, P., Lai-Kwon, J., Nekhlyudov, L., Rynderman, M., & Jefford, M. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00242-2 · Cited by 326
Bower, J. E., Lacchetti, C., Alici, Y., Barton, D. L., Bruner, D. W., Canin, B. E., Escalante, C. P., Ganz, P. A., Garland, S. N., Gupta, S., et al. (2024) · Journal of Clinical Oncology · doi:10.1200/jco.24.00541 · Cited by 328
D’Silva, A., Fox, D. E., Nasser, Y., Vallance, J. K., Quinn, R. R., Ronksley, P. E., & Raman, M. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.06.034 · Cited by 172
Prevalence of cancer-related fatigue based on severity: a systematic review and meta-analysis
Kang, Y.-E., Yoon, J.-H., Park, N.-H., Ahn, Y., Lee, E., & Son, C. (2023) · Scientific Reports · doi:10.1038/s41598-023-39046-0 · Cited by 165
Zhu, Z., Sun, Y., Kuang, Y., Yuan, X., Haiyan, G., Zhu, J., & Xing, W. (2022) · Cancer Medicine · doi:10.1002/cam4.4904 · Cited by 137
Metadata
- Authors
- Al Maqbali, M., Al Sinani, M., Al Naamani, Z., Al Badi, K., & Tanash, M. I.
- Affiliations
- Hashemite University (JO)
- Venue
- Journal of Pain and Symptom Management
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 61
- Issue
- 1
- Pages
- 167-189.e14
- ISSN
- 0885-3924 (ISSN-L)
- OpenAlex
- W3047104495
- Cited by
- 288
- References
- 170
- Citations by year
- 2026: 55 · 2025: 65 · 2024: 67 · 2023: 49 · 2022: 35 · 2021: 17
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain and Symptom Management (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- cancer-related fatigue, fatigue prevalence, cancer patients, advanced cancer, cancer therapy, gynecologic cancer, gender differences, quality of life, symptom monitoring
- MeSH terms
- Fatigue, Female, Humans, Neoplasms, Quality of Life, Prevalence
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